HOME >> BIOLOGY >> NEWS
Genetic defect links respiratory disease and congenital heart disease

CHAPEL HILL - The same genetic defect that causes a rare respiratory disease may also lead to some types of congenital heart disease, according to a study from the University of North Carolina at Chapel Hill School of Medicine.

The link between the two diseases starts with cilia, the tiny, hair-like extensions that help the lungs clear of mucus and remove contaminants such as dust. The researchers first noticed the connection in children with a respiratory disease that affects cilia, primary ciliary dyskinesia (PCD). A genetic mutation that impairs cilia movement causes the disease. A few children treated for PCD at UNC-Chapel Hill also had heterotaxy - an abnormal position of the heart and lungs associated with congenital heart disease.

The research team wondered if PCD and heterotaxy were related because other types of cilia, called nodal cilia, are known to play a role in directing and organizing organs in developing embryo. Results of the new study indicate they are connected.

The prevalence of heterotaxy and congenital heart defects was 200-fold higher in people with PCD than in the general population (one in 50 versus one in 10,000), the study found. The research appears in the June 5, 2007, issue of the journal Circulation.

"This should spur physicians treating patients with congenital heart disease to be more vigilant about testing for and treating respiratory defects," said Dr. Michael R. Knowles, professor of pulmonary and critical care medicine and study senior author. "It is critical for families and physicians to recognize when congenital heart disease develops."

Children with both heterotaxy and congenital heart disease typically undergo surgery to repair heart defects, and if they have respiratory complications after surgery, it's often assumed that the cause is their heart problems, Knowles said. But the study indicates these children's respiratory problems may also have an unde
'"/>

Contact: Les Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
11-Jun-2007


Page: 1 2

Related biology news :

1. Genetic variation helps to understand predisposition to schizophrenia
2. Genetic factors strongly shape how peers are chosen
3. Genetic analysis finds greater threat in frog-killing fungus
4. Genetic diversity in honeybee colonies boosts productivity
5. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
6. Maynard Olson receives $500,000 Gruber Genetics Prize
7. Cell Press announces new partnership with the American Society of Human Genetics
8. Genetic fellow traveler discovered in Alzheimers
9. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
10. Health disparities -- Genetics, society and race play an important role in access to healthcare
11. Genetic studies endow mice with new color vision

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/30/2019)... SANTA BARBARA, Calif. (PRWEB) , ... September 30, ... ... global technology consulting firm focused on increasing the capacity of life science organizations ... BoxWorks 2019 in San Francisco, CA on October 4th. , What: Just 30 ...
(Date:9/30/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... for novel product formulations related to “Ready-to-Print” (RTP) cellular product formats (patent ...
(Date:9/25/2019)... AUSTIN, Texas (PRWEB) , ... September 25, 2019 ... ... Implant Center in Austin, TX, have placed over 20,000 dental implants for a ... and the highly technical zygomatic and pterygoid dental implants. Dental implants ...
Breaking Biology News(10 mins):
(Date:9/22/2019)... ... September 20, 2019 , ... ... Neurotrophic Factor (BDNF) testing in serum . BDNF plays a vital role in ... growth and differentiation of new neurons in the brain involved in learning, memory, ...
(Date:9/17/2019)... ... ... Jennifer Hermansky and Fang Xie, Ph.D. , attorneys from ... Rising Stars. Hermansky and Xie, named an Immigration Rising Star and a Life Sciences ... areas. The list highlights attorneys “whose legal accomplishments transcend their age,” according to Law360. ...
(Date:9/11/2019)... OF PRUSSIA, Pa. (PRWEB) , ... September 09, ... ... complex problems for life sciences companies and government agencies, announced that its president ... an invitation-only group of successful business leaders. , The Forbes Council accepted Gallivan ...
(Date:9/9/2019)... ... 09, 2019 , ... Visikol CEO Dr. Michael Johnson recently gave a ... to characterize 3D cell culture models. The inherent problem of characterizing 3D cell culture ... to image through and therefore traditional wide-field or even confocal microscopy only tells you ...
Breaking Biology Technology:
Cached News: