HOME >> BIOLOGY >> NEWS
Genetic discovery paves way to decode sense of smell in mammals

ct food sources and potential toxins and to identify suitable mates. The sensory ability depends initially on olfactory nerve cells in the lining of the nose.

Scientists first identified olfactory receptors in mammals 10 years ago a discovery that won the 2004 Nobel Prize in Physiology or Medicine. Each olfactory neuron bears only one type of olfactory protein receptor on its surface, forming the cellular basis for discrimination among smells, Matsunami explained. Mice have as many as 1,000 different odorant receptors, while humans with a relatively poorer sense of smell have 350 of the protein receptors for smell. However, the selectivity of those different receptors for chemical stimuli remains unclear, he added.

The researchers' extensive search for proteins involved in delivering odorant receptor proteins to the surface of olfactory nerves revealed two proteins, which they named receptor transporting proteins one and two (RTP1 and RTP2). The researchers found that genes encoding the proteins were specifically active in olfactory neurons. Furthermore, RTP1 and RTP2 interact with olfactory receptor proteins and enhance their function, they found.

The researchers reported similar, although much weaker effects, for a third protein, which they called receptor expression enhancing protein one (REEP1).

To demonstrate the utility of the accessory proteins for elucidating the sense of smell, the team created cells with constantly high levels of RTP1, RTP2, REEP1, and another protein known to bind olfactory receptors. The enhancement of these protein levels made it possible for the researchers to induce the newly created cells to express odorant receptors at their surfaces. The team then tested the receptors' response to various chemicals, including the fishy-smelling aliphatic acids and sweet-smelling coumarine and piperonal.

Through these experiments, the researchers identified seven new olfa
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-660-1306
Duke University Medical Center
23-Nov-2004


Page: 1 2 3

Related biology news :

1. Genetic variation helps to understand predisposition to schizophrenia
2. Genetic factors strongly shape how peers are chosen
3. Genetic analysis finds greater threat in frog-killing fungus
4. Genetic diversity in honeybee colonies boosts productivity
5. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
6. Maynard Olson receives $500,000 Gruber Genetics Prize
7. Genetic defect links respiratory disease and congenital heart disease
8. Cell Press announces new partnership with the American Society of Human Genetics
9. Genetic fellow traveler discovered in Alzheimers
10. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
11. Health disparities -- Genetics, society and race play an important role in access to healthcare

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... Research and Markets has announced the addition of the ... Forecast to 2025" report to their offering. ... The Global Vehicle Anti-Theft System ... over the next decade to reach approximately $14.21 billion by 2025. ... forecasts for all the given segments on global as well as ...
(Date:3/20/2017)... March 20, 2017 PMD Healthcare announces the ... and Wellness Management System (WMS), a remote, real-time lung ... 2010, PMD Healthcare is a Medical Device, Digital Health, ... dedicated to creating innovative solutions that empower people to ... intent focus, PMD developed the first ever personal spirometer, ...
(Date:3/7/2017)... 7, 2017 Brandwatch , the leading social intelligence ... Prince,s Trust to uncover insights to support its reporting, help ... The UK,s leading youth charity will be using Brandwatch Analytics ... get a better understanding of the topics and issues that are ... ...
Breaking Biology News(10 mins):
(Date:4/27/2017)... ... April 27, 2017 , ... ... pathology, today announced their digital pathology technology has the potential to eliminate subjectivity ... medical centers in The Netherlands as part of the 2017 ISBI CAMELYON ...
(Date:4/27/2017)... ... April 27, 2017 , ... ... why mass flow controllers based on capillary thermal mass flow technology provide exponentially ... flow control applications. Over 80% of all industrial processes—such as those involving ...
(Date:4/27/2017)... -- Kinexum, a distinguished resource for research, development and commercialization ... Thomas C. Seoh as President and CEO. Mr. ... who becomes Executive Chairman and will continue to serve ... Thomas Seoh commented, "I am excited and ... the firm,s remarkable team of life science professionals, all ...
(Date:4/26/2017)... ... 26, 2017 , ... Baltimore bio tech firm, PathSensors, Inc., ... solution at the National Postal Forum 2017 in Baltimore, Maryland, May 21st through ... easy to use and low cost threat detection solution for government and commercial ...
Breaking Biology Technology:
Cached News: