HOME >> BIOLOGY >> NEWS
Genetic discovery paves way to decode sense of smell in mammals

ct food sources and potential toxins and to identify suitable mates. The sensory ability depends initially on olfactory nerve cells in the lining of the nose.

Scientists first identified olfactory receptors in mammals 10 years ago a discovery that won the 2004 Nobel Prize in Physiology or Medicine. Each olfactory neuron bears only one type of olfactory protein receptor on its surface, forming the cellular basis for discrimination among smells, Matsunami explained. Mice have as many as 1,000 different odorant receptors, while humans with a relatively poorer sense of smell have 350 of the protein receptors for smell. However, the selectivity of those different receptors for chemical stimuli remains unclear, he added.

The researchers' extensive search for proteins involved in delivering odorant receptor proteins to the surface of olfactory nerves revealed two proteins, which they named receptor transporting proteins one and two (RTP1 and RTP2). The researchers found that genes encoding the proteins were specifically active in olfactory neurons. Furthermore, RTP1 and RTP2 interact with olfactory receptor proteins and enhance their function, they found.

The researchers reported similar, although much weaker effects, for a third protein, which they called receptor expression enhancing protein one (REEP1).

To demonstrate the utility of the accessory proteins for elucidating the sense of smell, the team created cells with constantly high levels of RTP1, RTP2, REEP1, and another protein known to bind olfactory receptors. The enhancement of these protein levels made it possible for the researchers to induce the newly created cells to express odorant receptors at their surfaces. The team then tested the receptors' response to various chemicals, including the fishy-smelling aliphatic acids and sweet-smelling coumarine and piperonal.

Through these experiments, the researchers identified seven new olfa
'"/>

Contact: Kendall Morgan
kendall.morgan@duke.edu
919-660-1306
Duke University Medical Center
23-Nov-2004


Page: 1 2 3

Related biology news :

1. Genetic variation helps to understand predisposition to schizophrenia
2. Genetic factors strongly shape how peers are chosen
3. Genetic analysis finds greater threat in frog-killing fungus
4. Genetic diversity in honeybee colonies boosts productivity
5. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
6. Maynard Olson receives $500,000 Gruber Genetics Prize
7. Genetic defect links respiratory disease and congenital heart disease
8. Cell Press announces new partnership with the American Society of Human Genetics
9. Genetic fellow traveler discovered in Alzheimers
10. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
11. Health disparities -- Genetics, society and race play an important role in access to healthcare

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/20/2016)... 2016   MedNet Solutions , an innovative SaaS-based ... clinical research, is pleased to announce the attainment of ... the result of the company,s laser focus on (and ... , it,s comprehensive, easy-to-use and highly affordable cloud-based technology ... Key MedNet growth achievements in 2015 include: ...
(Date:1/18/2016)... Calif. , Jan. 18, 2016  Extenua ... software that simplifies the use and access of ... and go-to-market partnership with American Cyber.  ... brings extensive experience leading transformational C4ISR and Cyber ... and integrating the latest proven technology solutions," said ...
(Date:1/13/2016)... January 13, 2016 --> ... a new market report titled - Biometric Sensors Market - ... 2015 - 2023. According to the report, the global biometric sensors ... anticipated to reach US$1,625.8 mn by 2023, expanding at ... terms of volume, the biometric sensors market is expected ...
Breaking Biology News(10 mins):
(Date:2/4/2016)... ... , ... Shimadzu Scientific Instruments will showcase several new products, ... sessions, and present on the analysis of mycotoxins and medical cannabis at the ... at the Georgia World Congress Center in Atlanta, Georgia. , Attendees should ...
(Date:2/4/2016)... YORK , February 4, 2016 ... QBIO), a biotechnology acceleration company is pleased to provide the ... --> Over the last 3 months we ... and securities purchase agreements exceeding $1,000,000. As a result, we ... our Mannin Research Inc. license agreement and expect that development ...
(Date:2/4/2016)... Strasbourg, France , to the US ... Strasbourg, France , to the US company Advanced Bioscience ... announce that it acted as an advisor to Transgene on ... Strasbourg, France , to the US company Advanced Bioscience ... Transgene (Euronext: TNG), a member of Institut Mérieux, is ...
(Date:2/3/2016)... , Feb. 3, 2016 Ascendis Pharma A/S ... that applies its innovative TransCon technology to address significant ... an upcoming investor conference.Event:2016 Leerink Partners Global Healthcare Conference ... , Wednesday, February 10, 2016 Time:  , 11:55am ... . --> An audio webcast of this ...
Breaking Biology Technology:
Cached News: