HOME >> BIOLOGY >> NEWS
Genetic factors important in development and timing of Alzheimer's disease

In a large study of twins, Alzheimer's disease appears to be highly heritable and genetic factors may also influence timing of the disease, according to an article in the February Archives of General Psychiatry, one of the JAMA/Archives journals.

Two-thirds of adults aged 65 years and older with dementia have Alzheimer's disease (AD), and the number of AD cases is predicted to increase with the growing older adult population. Although genetic risk factors for AD have been identified, only a fraction of AD cases can be explained by specific gene mutations. Studies of twins have been helpful in investigating the relative importance of genetic and environmental influences in disease development. For example, if identical (monozygotic) twins do not both have a disease, environmental factors may be implicated for its occurrence.

Margaret Gatz, Ph.D., University of Southern California, Los Angeles, and colleagues evaluated 11,884 pairs of twins from the Swedish Twin Registry to examine the association between genetic and environmental influences and AD. The study included patients from the registry who tested positive for dementia and their twins, plus a sample of twins without dementia. The researchers identified 392 pairs of twins in which one or both had AD.

The researchers estimated heritability for AD to be between 58 and 79 percent. Among pairs where both twins had AD, there was an average of 3.66 years difference in age at onset between 25 sets of identical twins, and 8.12 years difference between 20 sets of fraternal (dizygotic) twins. This lead the researchers to conclude that genes had a role in disease timing "because age at onset of AD is significantly more similar for concordant [occurring in both twins] monozygotic pairs compared with concordant dizygotic pairs." Concordance rates were higher in women, reflecting their greater longevity.

"In the largest twin study to date, we confirmed that heritability for AD is hig
'"/>

Contact: Carl Marziali
213-740-4751
JAMA and Archives Journals
6-Feb-2006


Page: 1 2

Related biology news :

1. Genetic variation helps to understand predisposition to schizophrenia
2. Genetic factors strongly shape how peers are chosen
3. Genetic analysis finds greater threat in frog-killing fungus
4. Genetic diversity in honeybee colonies boosts productivity
5. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
6. Maynard Olson receives $500,000 Gruber Genetics Prize
7. Genetic defect links respiratory disease and congenital heart disease
8. Cell Press announces new partnership with the American Society of Human Genetics
9. Genetic fellow traveler discovered in Alzheimers
10. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
11. Health disparities -- Genetics, society and race play an important role in access to healthcare

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2019)... ... May 20, 2019 , ... Dr. David Greene , ... The documentary, Stem Cell Therapy: Biotechnology to the Rescue, was produced by Award Winning ... Greene was interviewed in regards to the safety of the procedures along with the ...
(Date:5/21/2019)... Pa. (PRWEB) , ... May 20, 2019 , ... ... for the health care field, today announced a 96.15% pass rate for first-time ... of 2019. This surpasses the national average of 76.43% by nearly 20 points. ...
(Date:5/16/2019)... (PRWEB) , ... May 16, 2019 , ... In a ... and Technology in Rockville, Maryland, March 18-19 of this year, Asymmetrex founder ... the feasibility of standards for counting therapeutic adult tissue stem cells. Many of ...
Breaking Biology News(10 mins):
(Date:4/18/2019)... ... April 18, 2019 , ... Taking a ... includes a chemical engineer at Worcester Polytechnic Institute (WPI) has developed a novel ... possible to manufacture isobutanol and other biofuels more economically. , Isobutanol, like ethanol, ...
(Date:4/16/2019)... ANTONIO (PRWEB) , ... April 16, 2019 , ... ... human identification systems, applications, and technology, today announced that Bank South Pacific (BSP), ... a competitive RFP process. The bank awarded Fulcrum a contract to deliver a ...
(Date:4/12/2019)... (PRWEB) , ... April 12, 2019 , ... ... recent developments in neurotechnology and will educate about innovative tools and devices being ... your local listings for more information. , This segment of Advancements will focus ...
(Date:4/10/2019)... ... ... After more than three months of renovation, Lajollacooks4u is set to reveal its ... modern lighting and fixtures, and will provide additional workspace for the many guests who ... the demand for our team-building events and cooking classes over the last eleven years,” ...
Breaking Biology Technology:
Cached News: