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Genetic 'fellow traveler' discovered in Alzheimer's

lzheimers.

Studies of the GAB2 gene have indicated that the protein it produces controls a biochemical pathway that protects against the abnormal formation of protein tangles that kill brain cells, said the researchers. To explore the genes role, they experimentally silenced the gene in neurons, observing an increase in the form of a key protein that contributes to such tangles.

Discovery of this novel LOAD susceptibility gene provides new opportunities to investigate LOAD pathogenesis, predisposition, treatment, and prevention, concluded the researchers.


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Contact: Erin Doonan
edoonan@cell.com
617-397-2802
Cell Press
6-Jun-2007


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