HOME >> BIOLOGY >> NEWS
Genetic finding suggests alternative treatment strategy for common, complex skin disorders

BETHESDA, Md.-- A genetic finding by researchers at the National Institutes of Health provides new insight into the cause of a series of related, common and complex illnesses including hay fever and asthma as well as the skin disorders eczema and psoriasis and suggests a novel therapeutic approach. These illnesses are essentially inflammatory disorders of the tissues that separate the inside of the body from the outside world, such as the skin and the linings of the throat and lungs.

In the May issue of The Journal of Clinical Investigation, researchers from the National Human Genome Research Institute, the National Eye Institute, and the National Institute of Child Health and Human Development, all part of the National Institutes of Health, report that excessive production of a specific protein disrupts the protective properties of the skin barrier. Once the skin barrier is compromised, immune-system-stimulating chemicals allergens can enter the body and cause an inflammatory reaction that, in turn, stimulates skin cells to grow rapidly, further diminishing the protective function of the skin. The compromised barrier, in turn, becomes more porous to allergens that then stimulate more inflammation in a cycle that eventually produces common skin conditions such as psoriasis and eczema.

It may, however, be possible to break the cycle by creating a temporary, artificial barrier on the skin that blocks incoming allergens. The solution could be as simple as developing a lotion that effectively blocks allergens from getting through damaged skin. Keeping allergens out of the skin would keep the immune system from over-stimulating cell growth, giving the skin time to re-create a normal barrier. Current therapies for these skin conditions principally focus on suppressing the immune system, but the medicines used can produce undesired side-effects.

"The human body is an incredibly complex system," said Elias A. Zerhouni, M.D., director of the Na
'"/>

Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
25-Apr-2006


Page: 1 2 3 4

Related biology news :

1. Genetic variation helps to understand predisposition to schizophrenia
2. Genetic factors strongly shape how peers are chosen
3. Genetic analysis finds greater threat in frog-killing fungus
4. Genetic diversity in honeybee colonies boosts productivity
5. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
6. Maynard Olson receives $500,000 Gruber Genetics Prize
7. Genetic defect links respiratory disease and congenital heart disease
8. Cell Press announces new partnership with the American Society of Human Genetics
9. Genetic fellow traveler discovered in Alzheimers
10. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
11. Health disparities -- Genetics, society and race play an important role in access to healthcare

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/25/2020)... ... June 24, 2020 , ... eClinical Solutions LLC ... services that accelerate drug development, is collaborating with Karyopharm Therapeutics (Nasdaq: KPTI ... patients with severe COVID-19. This is the first study of an XPO1 inhibitor ...
(Date:6/23/2020)... ... ... The field of quantitation of large molecules or proteins has been around ... the use of mass spectrometry in this field has gained a lot of momentum ... choose which approach to use (LBA or MS)?” In many cases, either technology ...
(Date:6/19/2020)... ... ... The director of stem cell biotechnology company Asymmetrex , Dr. James ... industries have easier access to stem cell counting, they will soon make it a ... Day weekend in the U.S., Asymmetrex is offering free tissue stem cell counting at ...
Breaking Biology News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... In most research using ... suppress pigment formation in zebrafish embryos, maintaining optical transparency to facilitate microscopic imaging. ... has been using the zebrafish model to investigate the causes of leukaemia and ...
(Date:7/7/2020)... ... 06, 2020 , ... R3 International is now offering stem cell therapy for ... cells. Depending on the patient's condition, treatment may be offered IV, intrathecal or with ... form of Alzheimers dementia, and the incidence continues to increase as individuals live longer. ...
(Date:7/1/2020)... ... June 29, 2020 , ... ... date growth of 40% in 2020, despite many obstacles created as a result ... to increase revenue for its partnered medical practices and medical manufacturers by expanding ...
(Date:7/1/2020)... , ... June 30, 2020 ... ... tissue data insights, today announced that the launch of a new ... with data about the tumor microenvironment (TME). , “Flagship’s TissueInsight is a ...
Breaking Biology Technology:
Cached News: