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Genetic finding suggests alternative treatment strategy for common, complex skin disorders

ies suggest that researchers now need to focus on both turning down the immune response, as well as restoring a normal skin barrier to keep the outside world out of the body.

"The barrier function of epithelial surfaces is important in all tissues that have contact with the outside world. In addition to the skin and respiratory tract, it includes the gastrointestinal tract, and the ocular surface," said Ali Djalilian, M.D., formerly a research fellow and medical officer at the National Eye Institute but now at the University of Illinois in Chicago, and the lead author of the paper. "These findings underline the importance of this barrier function and suggests a new strategy for restoring it in human diseases."


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Contact: Geoff Spencer
spencerg@mail.nih.gov
301-402-0911
NIH/National Human Genome Research Institute
25-Apr-2006


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