HOME >> BIOLOGY >> NEWS
Genetic roots of bipolar disorder revealed by first genome-wide study of illness

The likelihood of developing bipolar disorder depends in part on the combined, small effects of variations in many different genes in the brain, none of which is powerful enough to cause the disease by itself, a new study shows. However, targeting the enzyme produced by one of these genes could lead to development of new, more effective medications. The research was conducted by scientists at the National Institutes of Health's National Institute of Mental Health (NIMH), with others from the Universities of Heidelberg and Bonn and a number of U.S. facilities collaborating in a major project called the NIMH Genetics Initiative.

The study is the first to scan virtually all of the variations in human genes to find those associated with bipolar disorder. Results were published online May 8 in Molecular Psychiatry by Amber E. Baum, PhD, lead researcher Francis J. McMahon, MD, and colleagues.

"This is an example of how advances in genetics research feed into practical applications. This research would not have been possible a very few years ago. We now have a new molecular target scientists can investigate in their search for better medications for bipolar disorder," said NIH Director Elias A. Zerhouni, MD.

About 5.7 million American adults have bipolar disorder, which also is called manic-depressive illness. Symptoms include extremes in mood, from pronounced over-excitement and elation, often coupled with severe irritability, to depression. Children also may have the condition, usually in a more severe form than adults.

"We're beginning to get a foothold on the genetics of this complex brain disorder," said NIMH Director Thomas R. Insel, MD.

Most people occasionally have mood swings, but the shifts that occur in bipolar disorder, and the changes in behavior and energy level that accompany them, are sometimes disabling. Lithium and the other mood-stabilizing medications used to treat the condition help many pati
'"/>

Contact: Susan Cahill
scahill@mail.nih.gov
301-443-4536
NIH/National Institute of Mental Health
8-May-2007


Page: 1 2 3

Related biology news :

1. Genetic variation helps to understand predisposition to schizophrenia
2. Genetic factors strongly shape how peers are chosen
3. Genetic analysis finds greater threat in frog-killing fungus
4. Genetic diversity in honeybee colonies boosts productivity
5. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
6. Maynard Olson receives $500,000 Gruber Genetics Prize
7. Genetic defect links respiratory disease and congenital heart disease
8. Cell Press announces new partnership with the American Society of Human Genetics
9. Genetic fellow traveler discovered in Alzheimers
10. Health disparities -- Genetics, society and race play an important role in access to healthcare
11. Genetic studies endow mice with new color vision

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... ... 16, 2019 , ... At nearly eleven years old, Seve, a white Golden ... owner, in the last year or so, he was a little “gimpy” and occasionally ... Echevarria of VCA University Animal Hospital in Dallas, diagnosed him with severe ...
(Date:7/9/2019)... , ... July 09, 2019 , ... ... Tx Genetic Research into its incubator program. The founder and CEO of Tx ... improve the lives of those suffering from epithelial connective tissue disorders. , “We ...
(Date:6/27/2019)... ... June 27, 2019 , ... Lighting designers from integrated design firm ... which honored the designers for creating both engaging and energy efficient lighting systems. , ... an office tower in San Diego, California earned an IES Illumination Award of Merit ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... NEWPORT BEACH, Calif. (PRWEB) , ... May 30, ... ... the future of neurotoxins, is pleased to announce the strategic acquisition of Metabiologics, ... for research. The acquisition provides Object exclusive ownership and commercialization rights to a ...
(Date:5/15/2019)... ... May 15, 2019 , ... Milton Hershey School® has named William ... work within the biomedical industry, where he is changing lives by creating solutions to ... “William Harding epitomizes the vision of our founders – Milton and Catherine Hershey – ...
(Date:5/8/2019)... ... 2019 , ... Standing at 16.2 hands, Atlas is on the large side for a Quarter ... barrel racing, among other activities. When loping around a corner in late 2017, Atlas ... busy horse to only being able to walk. Fortunately Atlas’ owner, Kelly, sought the ...
(Date:5/2/2019)... ... April 30, 2019 , ... ... standard, REPROCELL USA Inc. has demonstrated its ability to provide various services ... aims to enhance customer satisfaction through the effective implementation of its quality ...
Breaking Biology Technology:
Cached News: