HOME >> BIOLOGY >> NEWS
Genetic variation helps to understand predisposition to schizophrenia

Bethesda, Md. Scientists have provided new insight into how a gene is related to schizophrenia. In a study to be published in the August 17 issue of the Journal of Biological Chemistry, Amanda J. Law, Medical Research Council Fellow and Associate Professor at the University of Oxford, United Kingdom, and Visiting Scientist at the National Institutes of Health (NIH), along with colleagues at NIH describe for the first time a genetic variation that causes a gene to be overexpressed in the human brain. These results may provide a new way to design better drugs to treat schizophrenia.

Although the exact causes of schizophrenia are yet to be determined, scientists agree that the disease is in part due to genetic variations, Law says. These variations are not simple to understand because they dont directly disturb the function of proteins. In our study, we identified some clues as to what goes wrong with one of these DNA variations.

The study was selected as a Paper of the Week by the journals editors, meaning that it belongs to the top one percent of papers reviewed in significance and overall importance.

Scientists originally found in an Icelandic population that genetic variations in a DNA sequence close to a gene that produces a protein called Neuregulin 1 were associated with schizophrenia, but how the Neuregulin 1 gene was affected remained unknown.

In 2006, Law and colleagues found that one of these DNA variations is associated with increased expression of a novel type of Neuregulin 1 called type 4 one of the six known types of Neuregulin 1 proteins in the brains of patients with schizophrenia.

The role of this protein in the brain is not completely understood but the other types of Neuregulin 1 proteins are involved in controlling how the brain develops and works in adults. In this study, Law and colleagues showed that Neuregulin 1 type 4 is specifically expressed in the
'"/>

Contact: Pat Pages
ppages@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
9-Aug-2007


Page: 1 2 3

Related biology news :

1. Genetic factors strongly shape how peers are chosen
2. Genetic analysis finds greater threat in frog-killing fungus
3. Genetic diversity in honeybee colonies boosts productivity
4. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
5. Maynard Olson receives $500,000 Gruber Genetics Prize
6. Genetic defect links respiratory disease and congenital heart disease
7. Cell Press announces new partnership with the American Society of Human Genetics
8. Genetic fellow traveler discovered in Alzheimers
9. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
10. Health disparities -- Genetics, society and race play an important role in access to healthcare
11. Genetic studies endow mice with new color vision

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/14/2019)... ... December 11, 2019 , ... Fiberstar, Inc., a ... beverage industry won the 2019 Food Ingredient Europe’s plant-based innovation award. , This ... plant-based foods category. Fiberstar who was one of three finalists achieved this award ...
(Date:12/4/2019)... ... December 04, 2019 , ... NDA Partners Chairman ... regulatory toxicology expert with more than 20 years of experience working in the ... Todd has extensive experience with a variety of biologic modalities including monoclonal antibodies, ...
(Date:11/27/2019)... Ellyn, IL (PRWEB) , ... November 26, 2019 ... ... Gibbs, invite patients to their Glen Ellyn, IL practice for Invisalign® ... straighten crooked teeth. , Patients with a misaligned bite, also known as malocclusion, ...
Breaking Biology News(10 mins):
(Date:1/7/2020)... ... January 07, 2020 , ... ... services, today announced the launch of its VivopureX™ recombinant mouse antibodies for in ... originally obtained from rats or hamsters, which Absolute Antibody has engineered into mouse-anti-mouse ...
(Date:1/7/2020)... SAN MATEO, CA (PRWEB) , ... January 06, ... ... Brilliant Smart Home Control, today announced its expansion into whole-home smart lighting with ... Brilliant Smart Dimmer Switch unlocks the ability for homeowners and homebuilders to affordably ...
(Date:12/31/2019)... ... December 31, 2019 , ... At this year's SLAS conference, Visikol ... broadly focused on 3D cell culture , advanced imaging and ... assays for assessing steatosis , inflammation and fibrosis as well as ...
(Date:12/27/2019)... ... December 27, 2019 , ... ... its 505(b)(2) product pipeline that offers patients and healthcare providers options ... concepts were identified in collaboration with doctors and managed care professionals and developed ...
Breaking Biology Technology:
Cached News: