HOME >> BIOLOGY >> NEWS
Genetic variation helps to understand predisposition to schizophrenia

Bethesda, Md. Scientists have provided new insight into how a gene is related to schizophrenia. In a study to be published in the August 17 issue of the Journal of Biological Chemistry, Amanda J. Law, Medical Research Council Fellow and Associate Professor at the University of Oxford, United Kingdom, and Visiting Scientist at the National Institutes of Health (NIH), along with colleagues at NIH describe for the first time a genetic variation that causes a gene to be overexpressed in the human brain. These results may provide a new way to design better drugs to treat schizophrenia.

Although the exact causes of schizophrenia are yet to be determined, scientists agree that the disease is in part due to genetic variations, Law says. These variations are not simple to understand because they dont directly disturb the function of proteins. In our study, we identified some clues as to what goes wrong with one of these DNA variations.

The study was selected as a Paper of the Week by the journals editors, meaning that it belongs to the top one percent of papers reviewed in significance and overall importance.

Scientists originally found in an Icelandic population that genetic variations in a DNA sequence close to a gene that produces a protein called Neuregulin 1 were associated with schizophrenia, but how the Neuregulin 1 gene was affected remained unknown.

In 2006, Law and colleagues found that one of these DNA variations is associated with increased expression of a novel type of Neuregulin 1 called type 4 one of the six known types of Neuregulin 1 proteins in the brains of patients with schizophrenia.

The role of this protein in the brain is not completely understood but the other types of Neuregulin 1 proteins are involved in controlling how the brain develops and works in adults. In this study, Law and colleagues showed that Neuregulin 1 type 4 is specifically expressed in the
'"/>

Contact: Pat Pages
ppages@asbmb.org
301-634-7366
American Society for Biochemistry and Molecular Biology
9-Aug-2007


Page: 1 2 3

Related biology news :

1. Genetic factors strongly shape how peers are chosen
2. Genetic analysis finds greater threat in frog-killing fungus
3. Genetic diversity in honeybee colonies boosts productivity
4. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
5. Maynard Olson receives $500,000 Gruber Genetics Prize
6. Genetic defect links respiratory disease and congenital heart disease
7. Cell Press announces new partnership with the American Society of Human Genetics
8. Genetic fellow traveler discovered in Alzheimers
9. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
10. Health disparities -- Genetics, society and race play an important role in access to healthcare
11. Genetic studies endow mice with new color vision

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/6/2019)... (PRWEB) , ... August 05, 2019 , ... Keck Graduate ... KGI School of Pharmacy and Health Sciences (SPHS). , “Dean Zdanowicz is highly regarded ... of Trustees Chairman Jim Widergren. “He is a great choice to build on the ...
(Date:8/6/2019)... , ... August 06, 2019 , ... ... and environmental concerns. One plant-based food in particular quickly entered the limelight – ... product developers use a thermogelling and emulsifying ingredient such as methyl cellulose. This ...
(Date:8/4/2019)... PRINCETON, N.J. (PRWEB) , ... August 02, 2019 ... ... expertise to assist the life science industry in advancing the development of medical ... has been recognized by PharmaVOICE magazine as one of the “100 Most Inspiring ...
Breaking Biology News(10 mins):
(Date:8/14/2019)... ... 13, 2019 , ... INDIGO Biosciences, Inc. (INDIGO), the recognized ... appointment of Mark McLoughlin to the Company’s Board of Directors. Mark brings four ... his healthcare expertise and extensive background in laboratory and scientific products manufacturing, distribution, ...
(Date:8/6/2019)... ... August 06, 2019 , ... The San Diego Biotechnology ... the biweekly SDBN BUZZ podcast focused on connecting the region’s biotech community and ... to promote the region and attract external employers, investors, scientists, and others who ...
(Date:8/4/2019)... MINNEAPOLIS (PRWEB) , ... August 02, 2019 , ... Cirtec ... minimally invasive devices, today announced that it has begun construction on a 30,000 sq. ... about 15 miles from San Jose. , The facility, which is expected to ...
(Date:7/19/2019)... ... 2019 , ... Global precision motion and piezo technology solutions ... facilities in Lederhose, Germany, increasing their current footprint by half again. , The ... addition to general office space, a significant increase to its existing 129,000ft² structure. ...
Breaking Biology Technology:
Cached News: