HOME >> BIOLOGY >> NEWS
Genetic variation impacts aspirin's effectiveness in preventing colon cancer, Dartmouth study finds

Dartmouth researchers are among a team of doctors that have learned more about how people may or may not benefit from taking aspirin in the effort to curb colon cancer.

Their study, which appears in the Oct. 18 issue of the Journal of the National Cancer Institute, finds that the beneficial effect of aspirin may be limited to individuals who have a specific genetic variation in their ODC gene.

"There is evidence that aspirin and related anti-inflammatory drugs can reduce the risk of colorectal adenomas [polyps] and cancer," says Elizabeth Barry, a research assistant professor of community and family medicine at Dartmouth Medical School, and one the authors of the study. "And with this study, we looked closer at the impact of aspirin in people who have a higher risk of developing colorectal adenomas, which lead to cancer, by examining their ODC genotype. So now we know that aspirin appears to work better in people who have this slight genetic variation, and this finding could potentially be clinically useful in the future by allowing physicians to predict which individuals are likely to benefit from aspirin use for colorectal cancer chemoprevention."

The researchers studied 973 subjects over three years as part of the Aspirin/Folate Polyp Prevention Study. In a randomized manner, some were given aspirin and some were given placebos. Almost half of the participants carried one or two copies of the ODC genetic variation.

The study found that there was no association between carrying the genetic variation and the occurrence or new adenomas, but the genotype did influence the effect of aspirin on adenoma development. Those with the ODC genetic variation were 23 percent less likely to develop new adenomas and 49 percent less likely to develop more advanced lesions, which also lead to cancer.


'"/>

Contact: Sue Knapp
Sue.Knapp@Dartmouth.edu
603-646-3661
Dartmouth College
24-Oct-2006


Page: 1

Related biology news :

1. Genetic variation helps to understand predisposition to schizophrenia
2. Genetic factors strongly shape how peers are chosen
3. Genetic analysis finds greater threat in frog-killing fungus
4. Genetic diversity in honeybee colonies boosts productivity
5. 2007-2008 Genzyme/ACMGF Clinical Genetics Fellowship In Biochemical Genetics award winner announced
6. Maynard Olson receives $500,000 Gruber Genetics Prize
7. Genetic defect links respiratory disease and congenital heart disease
8. Cell Press announces new partnership with the American Society of Human Genetics
9. Genetic fellow traveler discovered in Alzheimers
10. Genetic roots of bipolar disorder revealed by first genome-wide study of illness
11. Health disparities -- Genetics, society and race play an important role in access to healthcare

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/11/2019)... ... June 10, 2019 , ... Improved Pharma LLC announces the ... issue of AAPS PharmSciTech. The article was published online on April 29th, 2019. The ... along with Xiaoming Sean Chen of Purdue University. , The article is the most ...
(Date:6/6/2019)... , ... June 05, 2019 , ... ... the opening of a new network station and service center in Mexico City, ... 12th in the world — with more than $1.75 billion in pharmaceutical exports ...
(Date:6/4/2019)... (PRWEB) , ... June 04, 2019 , ... ... manufacturing of orthopedic medical devices, today announced Q1-19 revenues of $31M, up 12% ... combined with successful roll-out of strategic investments & operational excellence initiatives worldwide. , ...
Breaking Biology News(10 mins):
(Date:5/4/2019)... ... May 03, 2019 , ... More than three ... Pesquisas Association, the scientist and ufologist Urandir Fernandes de Oliveira, last Thursday (25), ... the results of some research carried out by the association, in partnership with ...
(Date:5/2/2019)... TORONTO (PRWEB) , ... May 02, 2019 , ... Stay ... pharma, biotech, medical device and food industries. Access to all webinars is free, so ... stay relevant in your field! , Visit http://www.xtalks.com to see our upcoming ...
(Date:4/25/2019)... , ... April 24, 2019 , ... ... Agents for sales and service organizations, today announced global availability of Inference ... providers and enterprises of all sizes to harness the power of Google’s ...
(Date:4/15/2019)... ... April 15, 2019 , ... Sirrus, Inc., a developer of ... plant expansion to increase production of methylene malonate monomers and oligomers. , The ... Sirrus’ full-scale production facility, which is scheduled to break ground in 2019. “The ...
Breaking Biology Technology:
Cached News: