HOME >> BIOLOGY >> NEWS
Genetically altered cells may help artificial skin fight infection

CINCINNATI -- Cincinnati burn researchers have created genetically modified skin cells that, when added to cultured skin substitutes, may help fight off potentially lethal infections in patients with severe burns.

Dorothy Supp, PhD, and her team found that skin cells that were genetically altered to produce higher levels of a protein known as human beta defensin 4 (HBD4) killed more bacteria than normal skin cells.

HBD4 is one in a class of proteins that exist throughout the body as part of its natural defense system. Researchers have only recently begun targeting these tiny molecules as a way to combat infections.

"If we can add these genetically modified cells to bioengineered skin substitutes, it would provide an important defense system boost during the initial grafting period, when the skin is most susceptible to infection," explains Supp, an adjunct research associate professor at the University of Cincinnati (UC) and researcher at Cincinnati Shriners Hospital for Children.

Supp says defensins could become an effective alternative method for burn wound care and infection control. Using them in cultured skin substitutes, she adds, could also decrease a patient's risk for infection, improve skin graft survival and reduce dependence on topical antibiotics.

UC researchers report these findings in the January issue of the Journal of Burn Care and Research.

Cultured skin substitutes are grown in a laboratory using cells from a burn patient's own skin. These cells are cultured, expanded and combined with a spongy layer of collagen to make skin grafts that are reattached to the burn wound.

"Cultured skin substitutes are improving the lives of many burn patients, but they also have limitations--including an increased susceptibility to infection," says Supp. "Because cultured skin grafts aren't connected to the circulatory system at the time of grafting, they aren't immediately exposed to
'"/>

Contact: Amanda Harper
amanda.harper@uc.edu
513-558-4657
University of Cincinnati
8-Jan-2007


Page: 1 2

Related biology news :

1. Genetically engineered blood protein can be used to split water into oxygen and hydrogen
2. Genetically altered mice no longer like cocaine
3. Genetically engineered mosquitoes show resistance to dengue fever virus
4. Genetically engineered animals help in scientific research that may benefit children
5. Genetically modified maize not found in southern Mexico
6. Genetically modified rice in China benefits farmers health, study finds
7. Genetically modified natural killer immune cells attack, kill leukemia cells
8. Genetically engineered corn poses no immediate threat to Mexican crops
9. Genetically endowed worm may substitute for rodents in some toxicology testing
10. Genetically modified parasite lets researchers probe immune systems memory
11. Antibiotic stress, genetic response and altered permeability of E. coli

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/17/2019)... CITY, S.D. (PRWEB) , ... July 16, 2019 , ... ... to form, or to detect bone loss before it causes osteoporosis. For South Dakota ... , “This is potentially a game-changer in terms of our ability to monitor ...
(Date:7/10/2019)... ... July 10, 2019 , ... ... for sales and service organizations, today announced its role in Pizza ... the operational efficiency of its franchisees. A key part of this initiative is ...
(Date:7/9/2019)... ... July 08, 2019 , ... KMK Consulting, ... of Cambridge, MA. This expansion strengthens KMK’s presence for the sales, support, and ... sales force effectiveness consulting for the biotechnology corridor. With this expansion, KMK ...
Breaking Biology News(10 mins):
(Date:5/31/2019)... ... , ... For many years, the primary forms of cancer treatment have been ... in immuno-oncology have led to the advent of Chimeric Antigen Receptor T (CAR T) ... known as “CARs”. The CAR enables the final product to produce chemicals in the ...
(Date:5/31/2019)... ... May 30, 2019 , ... ... on Data Integrity on July 08-09, 2019 in Boston, MA. This peer recommended ... medical device organizations. , The training will kick off with a compendial treatment ...
(Date:5/31/2019)... (PRWEB) , ... May 30, 2019 , ... ... the first to demonstrate an efficient delivery system for the sustained release of ... The platelet-rich plasma-based gel system was able to deliver CM into the injured ...
(Date:5/21/2019)... , ... May 21, 2019 , ... ... Berlin (VLB) today officially opened the inaugural Africa Brewing Conference dedicated to sharing ... industry in Africa. The event, which is supported through a partnership with “Ethiopia ...
Breaking Biology Technology:
Cached News: