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Genome changes tracked during multiple myeloma initiation, progression and treatment

nt with the concept of widespread changes in the expression of genes with cancer activity in the pathogenesis of MM, a concept with therapeutic and diagnostic implication for MM in particular and cancer in general," explains Dr. DePinho. The researchers suggest that on a broader scale in relation to the human cancer genome project, their results will serve to direct costly sequencing efforts toward those specific regions that contain genes displaying high pathogenic relevance. "This story clearly indicates that we are dealing with the tip of the iceberg when it comes to the universe of cancer genes," says Dr. DePinho.


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Contact: Heidi Hardman
hhardman@cell.com
617-397-2879
Cell Press
10-Apr-2006


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