Genomic analysis uncovers new targets for HIV vaccine

DURHAM, N.C. -- An international team of researchers has identified three gene variants in the DNA of 486 people infected with HIV that appear to have helped some of the patients fight off the virus and delay the onset of full-blown AIDS.

The researchers expect the new findings to aid the search for an HIV vaccine that would work by boosting the protective effects of one or more of these genes, and help the bodys own immune system overcome an infection. One of the genes looks particularly attractive as a vaccine target.

The study, published early online by the journal Science July 19, was directed by David Goldstein at Duke University and is the first large cooperative study with major findings arising from the Center for HIV/AIDS Vaccine Immunology, (CHAVI) a seven-year project funded by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, in 2005, led by Dukes Barton Haynes, M.D.

It took the international genetics team, called EuroCHAVI, pooling their cohorts of carefully selected patients and using the latest in genome-wide screening technology, 18 months to discover the three genes, that together greatly increase our knowledge of why patients differ in how well they can control the virus that causes AIDS.

These findings represent only the first of what investigators said will be a series of future genome-wide studies to pinpoint additional targets for HIV vaccines. In the new analysis, patients with specific gene variants in key immune system cells appear to be much better at controlling the proliferation of the virus after infection. These gene variants are known as polymorphisms.

These results not only approximately double our understanding of the factors that influence variation amongst individuals in how they control HIV-1, but also point torward new mechanisms of control, said David Goldstein, Ph.D., director of the Center for Population Genomics and Pha

Contact: Richard Merritt
Duke University Medical Center

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