HOME >> BIOLOGY >> NEWS
Genomic analysis uncovers new targets for HIV vaccine

rmacogenetics at Dukes Institute for Genome Sciences & Policy. Goldstein is the senior author of the paper.

As we expand the number of patients in future studies conducted by CHAVI researchers, we aim to discover even more polymorphisms that could provide additional clues how some patients are better able to control the virus than others, Goldstein. This should ultimately lead to novel targets for vaccines, the primary goal of CHAVI.

Two of the polymorphisms found were in genes controlling the human leukocyte antigen (HLA) system, which plays a major role in the immune system by identifying foreign invaders and tagging them for destruction.

Two of the HLA genes, known as HLA-A and B, are turned off by HIV when it enters the body, which keeps the immune system from recognizing the virus as foreign. HLA-C however is not thought to be turned off by HIV-1. The new results suggest that for some individuals at least HLA-C is involved in controlling HIV-1. Since HIV-1 appears unable to shut off HLA-C, unlike A and B, HLA-C may represent an Achilles heel of HIV, according to Goldstein, who said that a vaccine could be designed to elicit an HLA-C mediated response which HIV-1 might be unable to defuse.

This study was the first time a genome-wide approach has been used for an infectious disease, Goldstein said. Past studies have looked at individual candidate genes. Since different people respond differently to infections, a better understanding of how immune system genes control responses to infections should help us to design better treatments and more effective vaccines.

Added Haynes: CHAVI was designed to do big science, and the results of this analysis represent just the first of what should be many advances. The technology used and collaborative efforts involved were truly remarkable: together as a group we were able to do something that none of us individually could accomplish. The results of this and future CHAVI st
'"/>

Contact: Richard Merritt
Merri006@mc.duke.edu
919-660-1309
Duke University Medical Center
19-Jul-2007


Page: 1 2 3

Related biology news :

1. Genomics study provides insight into the evolution of unique human traits
2. Psychiatric Genomics Center established at Cold Spring Harbor Laboratory
3. Genomic signatures identify targeted therapies for lung cancer
4. NYUs Center for Comparative Functional Genomics part of $57 million MOD-ENCODE consortium
5. Genomic test could help detect radioactivity exposure from terrorist attacks
6. Elsevier launches new journal, Marine Genomics
7. Genomics throws species definition in question for microbes
8. Genomic variation easier to identify with UCSD/Brown software
9. Springer adds Genomic Medicine to biomedical publishing portfolio
10. Genomic firestorms underlie aggressive breast cancer progression
11. Genomic comparison of lactic acid bacteria published

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... , ... July 21, 2020 , ... ... transformation and innovation in technology and compliance, announces a new solution to manage ... must ensure every layer of their technology stack complies with FDA and global ...
(Date:7/10/2020)... ... July 08, 2020 , ... ... and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 ... study, but what is the most effective way to complete one? Will the ...
(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio ... findings of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host disease ... hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, this ...
Breaking Biology News(10 mins):
(Date:8/31/2020)... ... August 29, 2020 , ... ... manufacturing capability in Wuxi, China. The new plant operation will provide the local ... advanced technology. , “This facility will improve the flexibility of our offerings ...
(Date:8/12/2020)... ... August 12, 2020 , ... ... (EMMA International), a global leader in FDA compliance consulting has been named on ... private companies. The list represents a unique look at the most successful companies ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader in ... “BUILDING FOR LIFE.” The adoption of this taglines comes at a time of ... capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical treatments. ...
(Date:7/31/2020)... ... July 29, 2020 , ... The SDX® Respiratory ... 16 countries, has reached its 20th anniversary of worldwide use. Introduced in the ... top universities including University of Pennsylvania, University of Michigan, University of Maryland, University ...
Breaking Biology Technology:
Cached News: