HOME >> BIOLOGY >> NEWS
Genomic 'firestorms' underlie aggressive breast cancer progression

oncerted manner. 'Firestorms' were found in 25% of the breast cancer samples and were associated with negative clinical outcomes. The amplifications were generally limited to single chromosomal arms and were flanked by broad segments of low-copy-number duplications and deletions.

Another complex genomic profile, called 'sawtooth,' was present in 5% of breast cancer samples. It was characterized by narrow, low-copy-number deletions and duplications that were evenly distributed across the chromosomes. The 'simplex' profile, affecting 60% of the tumor samples, exhibited broad genomic duplications and deletions that only affected a single chromosomal arm. The remaining 10% of the samples exhibited a 'flat' profile, reflecting normal levels of copy number variation in the genome (see http://www.cshl.edu/public/releases/genome.html).

In addition to potential clinical applications, the profiles described in this study will be useful for assessing the relationship between 'firestorms' and the locations of candidate oncogenes and tumor suppressors in the genome. It will assist the researchers in identifying genes that drive cancer progression, and help unravel the complex yet elusive genetic pathway that underlies tumor metastasis.


'"/>

Contact: Maria A. Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
30-Nov-2006


Page: 1 2

Related biology news :

1. Genomics study provides insight into the evolution of unique human traits
2. Genomic analysis uncovers new targets for HIV vaccine
3. Psychiatric Genomics Center established at Cold Spring Harbor Laboratory
4. Genomic signatures identify targeted therapies for lung cancer
5. NYUs Center for Comparative Functional Genomics part of $57 million MOD-ENCODE consortium
6. Genomic test could help detect radioactivity exposure from terrorist attacks
7. Elsevier launches new journal, Marine Genomics
8. Genomics throws species definition in question for microbes
9. Genomic variation easier to identify with UCSD/Brown software
10. Springer adds Genomic Medicine to biomedical publishing portfolio
11. Genomic comparison of lactic acid bacteria published

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/23/2017)...  Hunova, the first robotic gym for the rehabilitation and functional motor ... Genoa, Italy . The first 30 robots will be ... USA . The technology was developed and patented at the ... spin-off Movendo Technology thanks to a 10 million euro investment from entrepreneur ... ...
(Date:4/19/2017)... The global military biometrics market ... by the presence of several large global players. The ... major players - 3M Cogent, NEC Corporation, M2SYS Technology, ... 61% of the global military biometric market in 2016. ... military biometrics market boast global presence, which has catapulted ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
Breaking Biology News(10 mins):
(Date:6/22/2017)... ... June 22, 2017 , ... ... the allergy specialists DST Diagnostische Systeme & Technologien GmbH, thereby expanding its product ... who suffers from hay fever, urticaria, asthma, atopic eczema or a food allergy. ...
(Date:6/22/2017)... ... June 22, 2017 , ... Tunnell Consulting’s thought ... life sciences industries, continue to be in demand for their insights and commentary ... speaking on “The State of Information Governance in the Biopharmaceutical Industry” at the ...
(Date:6/22/2017)... Lawrence, MA (PRWEB) , ... June 22, 2017 , ... ... completed ILVO validation. The AMPH test was determined to be appropriate as a screening ... for visual interpretation, on the Charm EZ system, and the Charm EZ Lite system. ...
(Date:6/20/2017)... ... June 20, 2017 , ... HorizonScan is providing food and ... most likely threat to their products at the annual IFT conference in Las ... food expo attracts over 20,000 attendees representing food science professionals from over 90 ...
Breaking Biology Technology:
Cached News: