HOME >> BIOLOGY >> NEWS
Genomic 'firestorms' underlie aggressive breast cancer progression

oncerted manner. 'Firestorms' were found in 25% of the breast cancer samples and were associated with negative clinical outcomes. The amplifications were generally limited to single chromosomal arms and were flanked by broad segments of low-copy-number duplications and deletions.

Another complex genomic profile, called 'sawtooth,' was present in 5% of breast cancer samples. It was characterized by narrow, low-copy-number deletions and duplications that were evenly distributed across the chromosomes. The 'simplex' profile, affecting 60% of the tumor samples, exhibited broad genomic duplications and deletions that only affected a single chromosomal arm. The remaining 10% of the samples exhibited a 'flat' profile, reflecting normal levels of copy number variation in the genome (see http://www.cshl.edu/public/releases/genome.html).

In addition to potential clinical applications, the profiles described in this study will be useful for assessing the relationship between 'firestorms' and the locations of candidate oncogenes and tumor suppressors in the genome. It will assist the researchers in identifying genes that drive cancer progression, and help unravel the complex yet elusive genetic pathway that underlies tumor metastasis.


'"/>

Contact: Maria A. Smit
smit@cshl.edu
516-422-4127
Cold Spring Harbor Laboratory
30-Nov-2006


Page: 1 2

Related biology news :

1. Genomics study provides insight into the evolution of unique human traits
2. Genomic analysis uncovers new targets for HIV vaccine
3. Psychiatric Genomics Center established at Cold Spring Harbor Laboratory
4. Genomic signatures identify targeted therapies for lung cancer
5. NYUs Center for Comparative Functional Genomics part of $57 million MOD-ENCODE consortium
6. Genomic test could help detect radioactivity exposure from terrorist attacks
7. Elsevier launches new journal, Marine Genomics
8. Genomics throws species definition in question for microbes
9. Genomic variation easier to identify with UCSD/Brown software
10. Springer adds Genomic Medicine to biomedical publishing portfolio
11. Genomic comparison of lactic acid bacteria published

Post Your Comments:
(Date:6/17/2015)... , June 17, 2015  Crossmatch™, a leading ... that its U.are.U ® 4500 fingerprint readers ... Eateries, Inc., a San Jose, ... to increase security, improve accountability and reduce fraud ... instant, non-repudiable identity confirmation for employee sign in ...
(Date:6/16/2015)... GOTHENBURG, Sweden , June 16, 2015 ... including all touch fingerprint sensors in the company,s portfolio from ... . Deliveries are planned to mainly take place during the ... manufacturers in Asia . Jörgen ... another evidence of    the   growing interest from smartphone ...
(Date:6/15/2015)... YORK , June 15, 2015 ... today from Telstra reveals the majority of US consumers using ... them via biometrics, such as fingerprint and voiceprint, instead of ... According to Telstra,s " Mobile Identity   - ... " report, with smartphones now the primary channel used ...
Breaking Biology News(10 mins):Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 2Togo's Eateries Improve Security and Accountability with Crossmatch Fingerprint Readers 3FPC Receives Order for Touch Fingerprint Sensors of 375 MSEK 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 2One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 3One in Four US Consumers Would Share Their DNA With Their Bank to Secure Financial and Personal Information, Telstra Report Finds 4
(Date:6/30/2015)... CA (PRWEB) , ... June 30, 2015 , ... ... Patients , Study will provide new insights on mechanics of fecal microbiota transplantation ... new partnership to study the microbiome of patients undergoing fecal microbiota transplantation (FMT) ...
(Date:6/30/2015)... , June 30, 2015  The University of ... Biosciences (CCE/Bio) and UC San Diego Extension announced ... be held Aug.  12 – 14, 2015, at ... three-day workshop provides an intense exposure to best ... and is well-suited to biologists, process engineers and ...
(Date:6/30/2015)... (PRWEB) , ... June 30, 2015 , ... ... prior to launching SmartArch — a revolutionary new archwire that allows orthodontists to ... further clinical evidence of the efficacy of SmartArch. “We’re thrilled about taking SmartArch ...
(Date:6/29/2015)... ... 2015 , ... The global microfluidics market is expected to ... to 2020). The market is mainly driven by the rising geriatric population, growing ... lack of adequate healthcare and research infrastructure in emerging markets, dearth of skilled ...
Breaking Biology Technology:uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 2uBiome and OpenBiome Partner for Microbiome Study in FMT Patients 3UC San Diego Extension to Offer Third Annual Microbial Fermentation Workshop 2New case studies for SmartArch orthodontic archwire paves way to product launch later this year 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 2Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 3Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 4Microfluidics Market Growing at 19.3% CAGR To 2020 – New research available at ReportsnReports.com 5
Cached News: