HOME >> BIOLOGY >> NEWS
Genomics reveals mechanism of heat resistance in bacteria

Warm-blooded creatures maintain a relatively stable body temperature that cannot tolerate the stress of intense heat (or cold). When it's too hot proteins destabilize and degrade--in some cases, with fatal results. But some bacterial and archaeal organisms appear to defy nature (as we think of it) by flourishing in extremely high temperatures. The archaeal microbe Pyrobaculum aerophilum, for example--originally found in a boiling marine water hole in Italy--thrives at ~100 C (212 F).

Published online this week in the open-access journal PLoS Biology Todd Yeates and colleagues from UCLA have investigated the mechanisms that engineer this remarkable heat resistance. By way of an elegant analysis of publicly available genome sequence and protein structure data, they answer the question: how do these thermophilic bacteria and archaea manage to maintain active, stable proteins at such high temperatures? The authors found that proteins from P. aerophilum along with some other thermophiles have many disulfide bonds (covalent bonds between two spatially proximate cysteines), which are known to improve stability.

By mapping intracellular gene sequences from 199 prokaryote genomes onto sequence-related proteins with known three-dimensional structures, they produced structural models which revealed when disulfide bonds are likely to form. A bias was found for disulfides in a set of thermophilic genomes. To prove that these predictions really do form disulfide bonds, the authors solved the structure of one protein from P. aerophilum--which was indeed stabilized by three disulfide bonds.

Disulfide bonds are more commonly formed outside or between cells in multicellular organisms. The high numbers of bonds observed in these prokaryotes challenge our ideas of how disulfide bonds form. Given the difficulty for disulfides to form in such organisms, the authors investigated which proteins are present in the disulfide-ri
'"/>

Contact: Paul Ocampo
press@plos.org
415-624-1224
Public Library of Science
22-Aug-2005


Page: 1 2

Related biology news :

1. Genomics study provides insight into the evolution of unique human traits
2. Psychiatric Genomics Center established at Cold Spring Harbor Laboratory
3. NYUs Center for Comparative Functional Genomics part of $57 million MOD-ENCODE consortium
4. Elsevier launches new journal, Marine Genomics
5. Genomics throws species definition in question for microbes
6. International Genomics Consortium, TGen to lead Biospecimen Core for Cancer Atlas pilot project
7. DOE JGI to host Microbial Genomics Workshop for educators
8. Genomics-based vaccine could prevent deadly cattle disease
9. NYUs Center for Comparative Functional Genomics helps to unravel the function of microRNAS
10. Genomics champion Eric Lander receives 2004 AAAS Public Understanding of Science & Technology Award
11. International Rice Functional Genomics meeting in Tucson Nov. 15-17

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:11/12/2019)... Ohio (PRWEB) , ... November ... ... Products , a global leader in the design and manufacturer of technical ... of seating and adjustable footrests compliant with Healthier Hospital Initiative guidelines. Established ...
(Date:11/9/2019)... ... November 08, 2019 , ... SiteSeer Technologies, creator of SiteSeer Professional retail ... client and user of SiteSeer. The boutique real estate developer of single and multi-tenant ... SiteSeer to supplement its own analysis of markets. , Geoffrey Kerth, manager of ...
(Date:11/6/2019)... ... November 06, 2019 , ... Genomenon® ... Genomic Search Engine now includes the ability to search the entirety of the ... patients with genetic and rare diseases. , Patients, particularly those with rare diseases, ...
Breaking Biology News(10 mins):
(Date:11/2/2019)... ... October 31, 2019 , ... drug360 graph, a breakthrough knowledge ... drug360 brings tellic’s expertise in biomedical language processing and machine learning to bear ... between genes, diseases, variants, phenotypes, and other biomedical entities. Researchers and analysts ...
(Date:10/29/2019)... ... October 29, 2019 , ... Researchers at ... Silios CMS-C multispectral imagers , researchers identified people by the image of ... on retinal imaging, face recognition, fingerprints and vasculature. , The new CMS4 ...
(Date:10/22/2019)... BOSTON (PRWEB) , ... October 22, 2019 , ... ... live biotherapeutics, has announced that its lead program, DBI-001, met its primary safety ... person open labeled phase 2a clinical trial for the treatment of interdigital tinea ...
(Date:10/10/2019)... ... October 09, 2019 , ... As World Mental Health ... and high school students have improved neuro-cognitive executive skills to enhance learning and ... and apply lifelong social/interpersonal, leadership, problem-solving and coping skills, due to an innovative ...
Breaking Biology Technology:
Cached News: