HOME >> BIOLOGY >> NEWS
Gladstone investigators discover how resting T cells avoid HIV infection

Scientists have discovered the mechanism that enables some CD4 T cells -- the main target of HIV -- to thwart the virus. The discovery, reported on April 13 in the online version of Nature, could open the door to an entirely new strategy for preventing the spread of HIV infection in the body's cells, according to the senior author of the study, Gladstone Institute of Virology and Immunology Director Warner C. Greene, MD, PhD.

The researchers, led by Ya-Lin Chiu, PhD, a postdoctoral fellow in the Greene lab, investigated why resting, nondividing CD4 T cells are impervious to HIV infection, while activated, dividing CD4 T cells are not. The team discovered that a potent antiviral factor called APOBEC3G (A3G) is the key.

The team, working in cell culture, found that A3G exists in two different-sized forms -- a small form that actively repels the virus, and a large form that is completely ineffective against it. Moreover, they detected only the small form in resting CD4 T cells, where HIV fails to grow, and only the large form in activated CD4 T cells, where the virus efficiently grows and wreaks havoc. They further showed that blocking production of the small, active form of A3G in resting CD4 T cells was sufficient to make these normally resistant resting cells highly susceptible to HIV infection.

"Until now, the prevailing belief has been that HIV failed to infect resting T-cells due to a simple lack of some essential factor or nutrient," says Greene, a professor of medicine, microbiology and immunology at the University of California, San Francisco. "This study now shifts the paradigm, showing that resting CD4 T cells actively repel HIV infection through the action of the small, enzymatically active form of A3G, which stops the virus in its tracks."

CD4 T cells are a class of lymphocytes, or white blood cells, that fight infection by orchestrating immune responses. They have the ability to recognize specific antigens -- foreign substance
'"/>

Contact: John Watson
jwatson@gladstone.ucsf.edu
415-734-2019
University of California - San Francisco
13-Apr-2005


Page: 1 2 3

Related biology news :

1. Gladstones Deepak Srivastava receives E. Mead Johnson Award for achievement in pediatrics
2. Gladstone scientists identify critical gene factor in heart development
3. Gladstone scientists prove neurons produce Alzheimers-linked apolipoprotein E
4. Gladstone Institutes receives funding for training grant from stem cell institute
5. Gladstone researchers hone in on differentiation of heart stem cells
6. Gladstone study links Alzheimers with toxic protein fragments
7. Gladstone researchers identify new drug target for Alzheimers disease
8. Gladstone Institutes assists with Exploratorium stem cell exhibit
9. CIRM awards $2.4 million training grant to the Gladstone Institutes
10. Gladstone investigator Steve Finkbeiner wins prestigious Lieberman Award
11. Gladstone building honored with San Francisco Business Times award

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2018)... ... 01, 2018 , ... RURO, Inc., a company known for ... is the software framework that all of RURO’s products are built from, and ... and the future of RURO’s laboratory software portfolio. , To accommodate the needs ...
(Date:7/31/2018)... DIEGO (PRWEB) , ... July 31, 2018 , ... ACEA ... analysis. The company has just introduced the xCELLigence RTCA S16, which the ... and monitored via an external computer, the S16can be placed in any standard CO2 ...
(Date:7/30/2018)... ... July 30, 2018 , ... TC Slade, ... impact of biofield energy healing treated Vitamin D3 on the strength and health ...     Over 260% increase in ALP, a bone-specific enzyme ,     Over 240% ...
Breaking Biology News(10 mins):
(Date:7/31/2018)... ... July 31, 2018 , ... Leading regenerative veterinary ... for extracting and using adipose tissue-derived stem cells to treat or prevent inflammation ... this patent covers Canada specifically, VetStem has been issued similar patents that cover ...
(Date:7/25/2018)... ... July 25, 2018 , ... Eileen ... impact of a biofield energy treated nutraceutical to improve skin health parameters including ... for skin health and reported the following results:,     More ...
(Date:7/25/2018)... ... July 25, 2018 , ... John McDonald, ... the board of the Indiana India Business Council (IIBC), an advocacy group to ... the current board of directors, McDonald joins an impressive roster of local and ...
(Date:7/22/2018)... , ... July 19, 2018 , ... ... driven channel professional has joined their team. With more than ten years of ... Adam will deliver his expertise as CallTower’s Channel Director for the Southwest and ...
Breaking Biology Technology:
Cached News: