HOME >> BIOLOGY >> NEWS
Gladstone researchers hone in on differentiation of heart stem cells

A team of scientists from the Gladstone Institute of Cardiovascular Disease (GICD) has identified a key factor in heart development that could help advance gene therapy for treating cardiac disorders.

Published in the current online edition of the Proceedings of the National Academy of Sciences, the study evaluates the role of short RNAs, also known as miRNAs, in the early stages of the developing heart. The study also will be reported in the December 27 issue of PNAS.

The findings could help cardiac stem cell researchers one day develop strategies for gene and cell- mediated cardiac therapies, according to Deepak Srivastava, MD, senior author and GICD director.

RNAs are nucleic acids found in all living cells that help transfer information from DNA to the protein-forming system of the cell. They also express--that is, instruct to turn on or off--genes within that transferred information. MiRNAs are short RNAs that repress gene expression to control a variety of developmental processes.

"Of all the medical disciplines that could potentially benefit from stem cell research, cardiology is among the most promising, but a better understanding of early heart development is crucial in order to move forward to stem cell-mediated therapies," says Srivastava, who holds appointments as professor in the Department of Pediatrics and the Wilma and Adeline Pirag Distinguished Professor in Pediatric Developmental Cardiology at UCSF.

In the study, which used Drosophila fly embryos as model systems, the research team demonstrated that a form of miRNA known as miR-1 helps in determination of heart progenitor cells (stem cells) in early embryonic stages. They also showed that miR-1 helps in maintenance of heart precursors in later embryonic stages.

In addition, researchers demonstrated that miR-1 can repress the ligand Delta, which otherwise binds to its receptor, Notch. The binding of Delta and Notch mediates development of many kind
'"/>

Contact: John Watson
jwatson@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
16-Dec-2005


Page: 1 2

Related biology news :

1. Gladstones Deepak Srivastava receives E. Mead Johnson Award for achievement in pediatrics
2. Gladstone scientists identify critical gene factor in heart development
3. Gladstone scientists prove neurons produce Alzheimers-linked apolipoprotein E
4. Gladstone Institutes receives funding for training grant from stem cell institute
5. Gladstone study links Alzheimers with toxic protein fragments
6. Gladstone researchers identify new drug target for Alzheimers disease
7. Gladstone Institutes assists with Exploratorium stem cell exhibit
8. CIRM awards $2.4 million training grant to the Gladstone Institutes
9. Gladstone investigators discover how resting T cells avoid HIV infection
10. Gladstone investigator Steve Finkbeiner wins prestigious Lieberman Award
11. Gladstone building honored with San Francisco Business Times award

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
(Date:5/20/2016)... -- VoiceIt is excited to announce its new marketing ... working together, VoiceIt and VoicePass will offer an ... slightly different approaches to voice biometrics, collaboration between ... Both companies ... "This marketing and technology partnership allows VoiceIt ...
(Date:5/9/2016)... , UAE, May 9, 2016 ... when it comes to expanding freedom for high net ... Even in today,s globally connected world, there is ... conferencing system could ever duplicate sealing your deal with ... obtaining second passports by taking advantage of citizenship via ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June, 23, 2016  The Biodesign Challenge (BDC), a ... ways to harness living systems and biotechnology, announced its ... in New York City . ... students, showcased projects at MoMA,s Celeste Bartos Theater during ... , MoMA,s senior curator of architecture and design, and ...
(Date:6/23/2016)... ... June 23, 2016 , ... In a new case ... Denmark detail how a patient who developed lymphedema after being treated for breast cancer ... could change the paradigm for dealing with this debilitating, frequent side effect of cancer ...
(Date:6/23/2016)... On Wednesday, June 22, 2016, the NASDAQ Composite ... Jones Industrial Average edged 0.27% lower to finish at 17,780.83; ... has initiated coverage on the following equities: Infinity Pharmaceuticals Inc. ... NKTR ), Aralez Pharmaceuticals Inc. (NASDAQ: ARLZ ), ... more about these stocks by accessing their free trade alerts ...
(Date:6/23/2016)... 22, 2016  Amgen (NASDAQ: AMGN ) ... QB3@953 life sciences incubator to accelerate the development ... laboratory space at QB3@953 was created to help high-potential ... for many early stage organizations - access to laboratory ... Amgen launched two "Amgen Golden Ticket" awards, providing each ...
Breaking Biology Technology:
Cached News: