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Gladstone researchers hone in on differentiation of heart stem cells

s of tissues and is involved in differentiation of cardiac stem cells into muscle cells.

"Given the importance of understanding cardiac progenitor determination and differentiation in current cardiac regenerative medicine, our study will contribute to the understanding of how heart progenitors differentiate to become mature heart cells in human heart development," explains Srivastava. "Finding the mechanism for how miR-1 regulates heart cell differentiation is very exciting. These insights into the fundamental questions of development may help us ultimately to harness the potential of stem cells for the treatment of heart disease and other afflictions."

"miRNAs bind to messenger RNAs and either degrade them or hinder their ability to make a protein," adds lead author Chulan Kwon, PhD, a GICD postdoctoral fellow. "miR-1 interferes with expression of a crucial gene that controls whether or not certain progenitor stem cells become heart cells. Thus it could be a target for future gene-mediated therapies to prevent early heart development problems."


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Contact: John Watson
jwatson@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
16-Dec-2005


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