HOME >> BIOLOGY >> NEWS
Gladstone researchers identify new drug target for Alzheimer's disease

San Francisco, Calif. (December 1, 2005)--Researchers at the Gladstone Institute of Neurological Disease have identified a potential new way to stop brain cell death related to Alzheimer's disease.

Working with cell cultures, the scientists investigated how amyloid beta proteins, which build up in the brain tissue of people with Alzheimer's disease, kill neurons. The cell cultures were established from brain tissue of laboratory rats. Study findings showed that amyloid beta could be prevented from causing neuronal cell death with a compound called resveratrol, which is also found as a natural ingredient in red wine.

"Our study suggests that resveratrol and related compounds may protect against neuronal loss associated with Alzheimer's disease," explains senior author Li Gan, PhD, a staff research investigator at the Gladstone Institute of Neurological Disease and an assistant professor of neurology at UC San Francisco. "This could certainly open up new avenues for drug development."

The research results are reported in the December 2 issue of the Journal of Biological Chemistry.

According to the research team, it was particularly interesting that the beneficial effect of resveratrol was not due to a direct impact on amyloid beta or on neurons but rather on other types of brain cells, called microglia.

Microglia are the immune cells of the brain. They can protect or hurt neurons, depending on which of their powerful defense or attack pathways are activated. The investigators found that amyloid beta triggers a pathway in microglia that makes them attack neurons with poisonous chemicals. A key mediator in this pathway is a protein called NF-kB, which resveratrol happens to block. Without resveratrol, amyloid beta activates NF-kB in microglia, turning them into powerful neuron killing machines. Researchers found that, in the presence of resveratrol or of other molecules that blocked NF-kB, microglia were well behaved, and
'"/>

Contact: John Watson
jwatson@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
1-Dec-2005


Page: 1 2

Related biology news :

1. Gladstones Deepak Srivastava receives E. Mead Johnson Award for achievement in pediatrics
2. Gladstone scientists identify critical gene factor in heart development
3. Gladstone scientists prove neurons produce Alzheimers-linked apolipoprotein E
4. Gladstone Institutes receives funding for training grant from stem cell institute
5. Gladstone researchers hone in on differentiation of heart stem cells
6. Gladstone study links Alzheimers with toxic protein fragments
7. Gladstone Institutes assists with Exploratorium stem cell exhibit
8. CIRM awards $2.4 million training grant to the Gladstone Institutes
9. Gladstone investigators discover how resting T cells avoid HIV infection
10. Gladstone investigator Steve Finkbeiner wins prestigious Lieberman Award
11. Gladstone building honored with San Francisco Business Times award

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/19/2017)... April 19, 2017 The global ... landscape is marked by the presence of several large ... held by five major players - 3M Cogent, NEC ... accounted for nearly 61% of the global military biometric ... in the global military biometrics market boast global presence, ...
(Date:4/11/2017)... , April 11, 2017 Crossmatch®, a ... authentication solutions, today announced that it has been ... Research Projects Activity (IARPA) to develop next-generation Presentation ... "Innovation has been a driving force ... program will allow us to innovate and develop ...
(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... July 17, 2017 , ... The Academy of Model ... of National Model Aviation Day will take place from 9 a.m. to 2 p.m. ... include activities for all ages. , Aviation Adventure Day will be packed with entertaining ...
(Date:7/17/2017)... , ... July 17, 2017 , ... ... and analytical instruments announced the launch of its new line of Heavy-Duty Orbital ... shaker models (both analog and digital) for laboratory applications. These shakers are ...
(Date:7/17/2017)... , ... July 17, 2017 , ... ... Weihong Hsing, Ph.D. , recently participated in the BiG (Biomedical Innovation Group) annual ... dominated by discussions of CAR-T (chimeric antigen receptor T-cell) therapy, a rapidly developing ...
(Date:7/17/2017)... ... 2017 , ... DuPont Pioneer today announced the launch of ... dedicated to connecting third-party innovators with DuPont Pioneer scientists is now available and ... and digital solutions. , “DuPont Pioneer is building on its long history of ...
Breaking Biology Technology:
Cached News: