HOME >> BIOLOGY >> NEWS
Gladstone researchers identify new drug target for Alzheimer's disease

San Francisco, Calif. (December 1, 2005)--Researchers at the Gladstone Institute of Neurological Disease have identified a potential new way to stop brain cell death related to Alzheimer's disease.

Working with cell cultures, the scientists investigated how amyloid beta proteins, which build up in the brain tissue of people with Alzheimer's disease, kill neurons. The cell cultures were established from brain tissue of laboratory rats. Study findings showed that amyloid beta could be prevented from causing neuronal cell death with a compound called resveratrol, which is also found as a natural ingredient in red wine.

"Our study suggests that resveratrol and related compounds may protect against neuronal loss associated with Alzheimer's disease," explains senior author Li Gan, PhD, a staff research investigator at the Gladstone Institute of Neurological Disease and an assistant professor of neurology at UC San Francisco. "This could certainly open up new avenues for drug development."

The research results are reported in the December 2 issue of the Journal of Biological Chemistry.

According to the research team, it was particularly interesting that the beneficial effect of resveratrol was not due to a direct impact on amyloid beta or on neurons but rather on other types of brain cells, called microglia.

Microglia are the immune cells of the brain. They can protect or hurt neurons, depending on which of their powerful defense or attack pathways are activated. The investigators found that amyloid beta triggers a pathway in microglia that makes them attack neurons with poisonous chemicals. A key mediator in this pathway is a protein called NF-kB, which resveratrol happens to block. Without resveratrol, amyloid beta activates NF-kB in microglia, turning them into powerful neuron killing machines. Researchers found that, in the presence of resveratrol or of other molecules that blocked NF-kB, microglia were well behaved, and
'"/>

Contact: John Watson
jwatson@gladstone.ucsf.edu
415-734-2019
Gladstone Institutes
1-Dec-2005


Page: 1 2

Related biology news :

1. Gladstones Deepak Srivastava receives E. Mead Johnson Award for achievement in pediatrics
2. Gladstone scientists identify critical gene factor in heart development
3. Gladstone scientists prove neurons produce Alzheimers-linked apolipoprotein E
4. Gladstone Institutes receives funding for training grant from stem cell institute
5. Gladstone researchers hone in on differentiation of heart stem cells
6. Gladstone study links Alzheimers with toxic protein fragments
7. Gladstone Institutes assists with Exploratorium stem cell exhibit
8. CIRM awards $2.4 million training grant to the Gladstone Institutes
9. Gladstone investigators discover how resting T cells avoid HIV infection
10. Gladstone investigator Steve Finkbeiner wins prestigious Lieberman Award
11. Gladstone building honored with San Francisco Business Times award

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2016)... , Dec. 5, 2016  The Office of ... published "Can CT Scans Enhance or Replace Medico ... potential of supporting or replacing forensic autopsies with ... scan. In response to recommendations made ... exploring using CT scans as a potential component ...
(Date:11/29/2016)... , Nov. 29, 2016 BioDirection, a ... point-of-care products for the objective detection of concussion and ... company has successfully completed a meeting with the U.S. ... Tbit™ blood test Pre-Submission Package. During the meeting company ... system as a precursor to commencement of a planned ...
(Date:11/22/2016)... 2016 According to the new market research report ... Vein, Signature, Voice), Multi-Factor), Component (Hardware and Software), Function (Contact and Non-contact), ... market is expected to grow from USD 10.74 Billion in 2015 to ... 2016 and 2022. Continue Reading ... ...
Breaking Biology News(10 mins):
(Date:12/9/2016)... MA (PRWEB) , ... December 09, 2016 , ... Aditya ... that in addition to Australia, Europe, and the United States, Axiomed is now gaining ... assure interest in this technology." , Mr. Humad went on to say that, “We ...
(Date:12/9/2016)... -- China Cord Blood Corporation (NYSE: CO ) ... provider of cord blood collection, laboratory testing, hematopoietic stem cell ... of its 2016 Annual General Meeting, which was held on ... . At the Annual General Meeting, ... Huazhen LLP as the independent auditors of the Company for ...
(Date:12/8/2016)... Board of Directors of the Pittsburgh Life Sciences ... only pure life sciences investment firm, today announced a ... developed by the Nominating and Governance Committee over the ... Jordan is selected to serve as President and ... who is elected to the position of Executive Chairman ...
(Date:12/8/2016)... Dec. 8, 2016  OncoSec Medical Incorporated ("OncoSec") ... DNA-based intratumoral cancer immunotherapies, today announced financial results ... "We are delivering on our commitment to ... ImmunoPulse® IL-12. We are pleased with the early ... trial, and we are focused on advancing our ...
Breaking Biology Technology:
Cached News: