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Global study concludes 'attack rate' of flu in kids is 55 percent lower with nasal spray vaccine

ST. LOUIS -- In a study spanning the United States, Europe, the Middle East and Asia, researchers writing in the Feb. 15 New England Journal of Medicine say a nasal spray flu vaccine reduced the influenza "attack rate" in children by 55 percent when compared with a group of children who received the traditional flu shot in the arm or thigh.

"Children get the flu twice as often as adults," said Robert Belshe, M.D., a vaccine researcher at Saint Louis University School of Medicine and the lead author of the study. "It's important to vaccinate kids against influenza -- and to identify new and more effective flu vaccine options -- because kids have a higher attack rate for influenza infection than adults. And children, when they bring the illness home, tend to pass it on to adults in their household."

The attack rate is the number of people who get sick as measured against the total number of people in a particular study population.

Belshe said the study points to new thinking about how to best protect very young children from influenza and offers insight into the safety and efficacy of influenza vaccines for children, whether administered through the nose or with a needle.

The study published in the New England Journal of Medicine was conducted in 8,475 children between the ages of 6 months and 5 years at 249 sites in 16 countries and was funded by MedImmune, Inc. It is the largest ever pediatric study comparing a nasal spray flu vaccine head-on with the traditional flu shot. About half of the children in the study received an FDA-approved injectable flu vaccine (which contains an inactivated flu virus), and the other half received a refrigerated version of the nasal spray influenza vaccine. The nasal spray influenza vaccine FluMist (Influenza Virus Vaccine Live, Intranasal) is currently FDA-approved for use in healthy people between 5 years and 49 years.

"We compared the attack rate of the flu in children who w
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Contact: Joe Muehlenkamp
muehlenk@slu.edu
314-977-8015
Saint Louis University
14-Feb-2007


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