HOME >> BIOLOGY >> NEWS
Gold nanoparticles could improve antisense cancer drugs

EVANSTON, Ill. --- In the fight against cancer, antisense drugs, which prevent genes from producing harmful proteins such as those that cause cancer, have the promise to be more effective than conventional drugs, but the pace of development of these new drugs has been slow.

Using gold nanoparticles combined with DNA, scientists at Northwestern University now have demonstrated a new method for developing antisense drugs that outperform conventional antisense agents. The findings will be published May 19 in the journal Science.

A major challenge has been delivering antisense drugs to cells inside the body while avoiding their break down along the way. The Northwestern team shows that by attaching multiple strands of antisense DNA to the surface of a gold nanoparticle (forming an "antisense nanoparticle") the DNA becomes more stable and can bind to the target messenger RNA (mRNA) more effectively than DNA that is not attached to a nanoparticle surface (as in commercial agents).

When compared to antisense DNA complexed with commercial agents such as Lipofectamine and Cytofectin, the antisense nanoparticles were more effective in gene knockdown (decreasing gene expression and protein production), were less susceptible to degradation resulting in longer lifetimes, exhibited lower toxicity and were more readily absorbed by cells, exhibiting a greater than 99 percent uptake.

"When mutations in the body's genetic material cause too many copies of certain proteins, cancer and other diseases can result," said Chad A. Mirkin, director of Northwestern's Center for Cancer Nanotechnology Excellence, who led the study. "Whereas typical drugs target the proteins, it is possible through gene therapy to target the genetic material itself before it is ever made into copies of harmful proteins. One way to target the genetic material is to block the messenger RNA by using 'antisense DNA,' which prevents the message from ever becoming a protein." <
'"/>

Contact: Megan Fellman
fellman@northwestern.edu
847-491-3115
Northwestern University
18-May-2006


Page: 1 2

Related biology news :

1. Gold nanoparticles may pan out as tool for cancer diagnosis
2. Under magnetic force, nanoparticles may deliver gene therapy
3. UCSB researchers show how to make polymeric micro- and nanoparticles
4. Pairing nanoparticles with proteins
5. In nature, proteins sweep up nanoparticles
6. Bacteria ferry nanoparticles into cells for early diagnosis, treatment
7. MU researchers examine the environmental effects of silver nanoparticles
8. Work with nanoparticles may lead to on-the-spot virus detector
9. Widely used iron nanoparticles exhibit toxic effects on neuronal cells
10. Test finds manufactured nanoparticles dont harm soil ecology
11. DNA nanoparticles hold promise in gene therapy for Parkinsons disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/2/2020)... ... July 01, 2020 , ... AltruBio ... findings of Neihulizumab, a biologic for the treatment of steroid-refractory acute graft-versus-host disease ... hemato-oncologist Dr. Paul J Martin of the Fred Hutchinson Cancer Research Center, this ...
(Date:6/28/2020)... ... , ... In an upcoming episode scheduled for the fall of 2020, Advancements ... (POCT). Check local listings for more info. , Today, the majority of testing is ... labs throughout the country. Results are then available several days later. Now, in an ...
(Date:6/23/2020)... , ... June 23, 2020 , ... ... is pleased to announce the next event in a series of TOPIQ webinars, ... The TOPIQ series of webinars was developed in response to social distancing measures ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... 13, 2020 , ... True Terpenes , the leading platform for terpene ... (SAB) to research the medical potential of terpenes and the potential entourage effect ... The board is focused on expanding the recently launched line of effects-based terpenes - ...
(Date:8/12/2020)... ... August 11, 2020 , ... ... chain validation engineering firm, is making available for free its new white ... incorporate concurrent transport simulation testing into today’s biologics licensing application (BLA). In ...
(Date:8/3/2020)... ... August 03, 2020 , ... ... announced Jim Corrigan, President and CEO has been named one of the 100 ... of industry sectors, PharmaVoice 100 honorees are selected based on how they have ...
(Date:7/31/2020)... ... 29, 2020 , ... G-CON Manufacturing, the leader in off-site ... FOR LIFE.” The adoption of this taglines comes at a time of tremendous ... to provide patients with urgently needed vaccines and other lifesaving pharmaceutical treatments. G-CON’s ...
Breaking Biology Technology:
Cached News: