HOME >> BIOLOGY >> NEWS
Gold nanoparticles may pan out as tool for cancer diagnosis

ther types of cells the technology utilizes are obtained from blood tests as opposed to biopsies.

The nanoparticles, or "gold nanorod molecular probes," are fabricated so that their size is unique to their target marker. That way, when nanorods bind to their marker, they "scatter," or disrupt light in a characteristic manner that researchers can then pair to the nanorod's dimensions, its antibody and the target cancer marker, which must be present for binding to occur.

More than 200,000 women are diagnosed with breast cancer every year in the United States, and 80 percent of those women receive some type of therapy, Irudayaraj said. Since 40 percent of them will have a relapse, regular monitoring, which this technology aims to do, is vital.

Irudayaraj said using gold nanorods for cancer detection will be about one-third the cost of the current analogous technology, called flow cytometry. This method works by attaching fluorescent probes to cancer cells, whereas the nanorod technology has its basis in sensing plasmons, or sub-atomic particles present in the gold nanoparticles.

The nanorods also require only a few cells, whereas flow cytometry requires hundreds to thousands of cells. This could be advantageous when dealing with scarce sample sizes, Irudayaraj said.

Irudayaraj and his team - postdoctoral researcher Chenxu Yu and Harikrishna Nakshatri, a researcher at the Indiana University School of Medicine - demonstrated that the nanorods bind to three different markers. Two of the markers were used to calculate the invasiveness of the cancer cell, while one marker - present equally among the different cancer types - was used to calculate the degree to which the other markers were expressed, or present. Irudayaraj said his gold nanorods may be able to detect as many as 15 different markers in the future, possibly opening the door for even more comprehensive tests.

Ultimately, Irudayaraj imagines a new kind o
'"/>

Contact: Douglas M. Main
dmain@purdue.edu
765-496-2050
Purdue University
31-Jul-2007


Page: 1 2 3

Related biology news :

1. Under magnetic force, nanoparticles may deliver gene therapy
2. UCSB researchers show how to make polymeric micro- and nanoparticles
3. Pairing nanoparticles with proteins
4. In nature, proteins sweep up nanoparticles
5. Bacteria ferry nanoparticles into cells for early diagnosis, treatment
6. MU researchers examine the environmental effects of silver nanoparticles
7. Work with nanoparticles may lead to on-the-spot virus detector
8. Widely used iron nanoparticles exhibit toxic effects on neuronal cells
9. Test finds manufactured nanoparticles dont harm soil ecology
10. DNA nanoparticles hold promise in gene therapy for Parkinsons disease
11. MIT develops nanoparticles to battle cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/10/2020)... ... July 08, 2020 , ... Overcoming Comparability Issues ... An FDAnews Webinar, Wednesday, July 22, 2020 • 1:30 p.m.-3:00 p.m. EDT, ... the most effective way to complete one? Will the study comply with all ...
(Date:7/2/2020)... ... July 02, 2020 , ... ... detailing the use of its revolutionary NEXTGENPCR endpoint thermocycler to test for ... minutes. The article, titled "Ultra-fast one-step RT-PCR protocol for the detection of ...
(Date:6/28/2020)... ... June 25, 2020 , ... In an upcoming episode ... in accelerated Point of Care Testing solutions (POCT). Check local listings for more info. ... at medical offices and are shipped to labs throughout the country. Results are then ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... ... August 13, 2020 , ... True Terpenes , the leading ... Scientific Advisory Board (SAB) to research the medical potential of terpenes and the potential ... combined with terpenes. The board is focused on expanding the recently launched line of ...
(Date:8/12/2020)... LEXINGTON, Mass. (PRWEB) , ... August 11, 2020 ... ... awarded $300,000 a year to expand the Facioscapulohumeral Muscular Dystrophy Clinical Trial ... year in 2021 and 2022. The network is a consortium of academic research ...
(Date:8/12/2020)... ... August 12, 2020 , ... Inc. magazine today revealed ... in FDA compliance consulting has been named on its annual Inc. 5000 list, ... a unique look at the most successful companies within the American economy’s most ...
(Date:8/3/2020)... ... August 03, 2020 , ... ERT, the global ... has been named one of the 100 most inspiring individuals in the life-sciences ... are selected based on how they have inspired their colleagues and affected positive ...
Breaking Biology Technology:
Cached News: