HOME >> BIOLOGY >> NEWS
Got milk? How breastfeeding affects HIV transmission

Mother to child transmission of HIV accounts for a large proportion of HIV infections in children, with many infected as a result of breastfeeding, which requires transfer of the virus across mucosal barriers. DC-SIGN, a DC lectin receptor, interacts with HIV and is found at high expression levels in tonsillar tissue.

In a paper appearing online on October 20 in advance of print publication of the November issue of the Journal of Clinical Investigation, William Paxton and colleagues from the University of Amsterdam clarify how human milk affects the HIV interactions with DC-SIGN that occur during breastfeeding.

The authors show that human milk can block the binding of HIV to the DC-SIGN molecule expressed on dendritic cells and potently inhibit the transfer of HIV-1 to CD4+ T-lymphocytes. The authors identify the component present in human milk that binds to DC-SIGN. The inhibitory effect can be fully alleviated with an antibody recognizing the Lewis X sugar epitope on this factor. Other major milk proteins do not bind to DC-SIGN nor inhibit viral transfer. These results demonstrate that protein associated Lewis X is necessary and sufficient to interact withDC-SIGN and block the interaction of DC-SIGN and HIV.

The identification of a factor in human milk that can block HIV-1 transmission, the ability of the factor to inhibit the virus from binding to DCs, and the potential immunomodulatory implications of such a compound has major implications for the development of agents that can block HIV transmission.


'"/>

Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
20-Oct-2005


Page: 1

Related biology news :

1. Alcohol consumption disrupts breastfeeding hormones
2. New clue why MS affects African-Americans differently than Caucasians
3. Sleep deprivation affects airport baggage screeners ability to detect rare targets
4. Economic impact of hunger affects all Americans
5. Sexual orientation affects how we navigate and recall lost objects, but age just targets gender
6. Growing nerve cells in 3-D dramatically affects gene expression
7. Estrogen fluctuation affects epileptic seizures
8. Experience affects new neuron survival in adult brain; study sheds light on learning, memory
9. Race affects tobacco absorption in children
10. New diabetes research: Half of Americans have gene that affects how body burns sugar
11. Rutgers College of Nursing dean authors a book on genetics and how it affects nursing and health

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/11/2019)... Va. (PRWEB) , ... February 11, 2019 , ... ... forensic DNA analysis products and services, announced a new forensic genealogy service offering ... (FGS) combines advanced DNA testing and genealogy to develop ancestral relationships between ...
(Date:2/2/2019)... ... January 31, 2019 , ... Pharmica Consulting ... clinical operations executives and focusing on all facets of clinical trial planning and ... portfolio management, resource management, patient engagement, and more. , “We have attended ...
(Date:1/30/2019)... ... January 30, 2019 , ... ... high-impact life science and biotechnology companies, announced today that it will host ... disease-focused venture funds to discuss their investment philosophies, explain their fund and ...
Breaking Biology News(10 mins):
(Date:1/30/2019)... , ... January 30, 2019 , ... ... microbial genomics, has awarded microbiome research support in study design, planning, sample collection, ... led by Dr. Marc D. Cook, PhD, to study the interactions between gut ...
(Date:1/24/2019)... ... , ... Outsourcing trials to contract research organizations (CRO) can ... creation and management generally requires manual effort. Additionally, each vendor organizes tasks and ... can ultimately lead to study start delays and change orders because tasks were ...
(Date:1/20/2019)... ... January 17, 2019 , ... The American Society of Gene & ... Education program , a new initiative for 2019. Designed by ASGCT committee volunteers in ... inform patients, families, and the public on the status and promise of gene and ...
(Date:1/11/2019)... ... January 11, 2019 , ... ... the automated collection of donor blood. This advanced and intuitive medical device ... unit incorporates the functionality needed for the busiest donor stations with new-to-the industry ...
Breaking Biology Technology:
Cached News: