HOME >> BIOLOGY >> NEWS
Green tea and COX-2 inhibitors combine to slow growth of prostate cancer

PHILADELPHIA -- Drinking a nice warm cup of green tea has long been touted for its healthful benefits, both real and anecdotal. But now researchers have found that a component of green tea, combined with low doses of a COX-2 inhibitor, could slow the spread of human prostate cancer.

In the March 1 issue of Clinical Cancer Research, researchers from University of Wisconsin-Madison demonstrate that low doses of the COX-2 inhibitor celecoxib, administered with a green tea polyphenol called pigallocatechin-3-gallate (EGCG), can slow the growth of human prostate cancer. Their experiments were performed in cell cultures and in a mouse model for the disease.

Celecoxib and green tea have a synergistic effect -- each triggering cellular pathways that, combined, are more powerful than either agent alone, said Hasan Mukhtar, Ph.D., professor of dermatology at the University of Wisconsin and member of Wisconsins Paul Carbone Comprehensive Cancer Center. We hope that a clinical trial could lead to a preventative treatment as simple as tea time.

Previous research has linked the cyclooxygenase-2 enzyme, commonly known as COX-2, to many cancer types, including prostate cancer, said Mukhtar. Mukhtar and his colleagues have previously shown COX-2 inhibitors like celecoxib (known under the brand name Celebrex) suppress prostate cancer in animal models. COX-2 inhibitors also have been shown to cause adverse cardiovascular effects when administered at high doses over long durations.

In 2004, Mukhtar and his colleagues demonstrated that green tea polyphenol EGCG has cancer-fighting abilities of its own. Their study, published in Cancer Research, showed that EGCG can modulate the insulin-like growth factor-1 (IGF-1)-driven molecular pathway in a mouse model for human prostate cancer, pushing the cells toward programmed cell death (apoptosis).

We believed that COX-2 inhibitors may still prove beneficial if used in combination
'"/>

Contact: Greg Lester
lester@aacr.org
267-646-0554
American Association for Cancer Research
1-Mar-2007


Page: 1 2 3

Related biology news :

1. Green tea boosts production of detox enzymes, rendering cancerous chemicals harmless
2. Greenlands ancient forests shed light on stability of ice sheet
3. Green Junta
4. Green Nanotechnology: Its Easier Than You Think
5. Stevens Center for Science Writings honors Edward O. Wilson with Green Book Award
6. Green payments are the future of agricultural support
7. Green Chemical Reactor Engineering -- XI
8. Climate changes are linked between Greenland and the Antarctic
9. Green plants share bacterial toxin
10. Mary Frances Lyon to receive Rockefellers Pearl Meister Greengard Prize
11. Green sturgeon receives threatened status

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/8/2019)... , ... May 08, 2019 , ... ... has successfully leveraged the support services provided by Medrio , the leading ... clinical trial sponsor agreement. , By collaborating to position high-quality CRO services ...
(Date:5/7/2019)... ... May 07, 2019 , ... AMGtime ... Convention and Entertainment Center from May 15- 17. At booth #226, AMGtime will ... include flexible software, biometric hardware, mobile apps, specialized industry solutions, advanced add-on modules, ...
(Date:5/2/2019)... ... 01, 2019 , ... uBiome, the leader in microbial genomics, ... General Counsel, as Interim Chief Executive Officer of uBiome, effective immediately. The Company’s ... There will also be an independent investigation into uBiome’s billing practices to be ...
Breaking Biology News(10 mins):
(Date:4/9/2019)... ... 09, 2019 , ... Sonny Bar Lisa, or Sonny for short, is a ... After a series of diagnostics, an MRI was performed which revealed Sonny had ... injury and found that VetStem Regenerative Cell Therapy may be a treatment ...
(Date:4/8/2019)... ... April 08, 2019 , ... ... solutions, announced today the launch of their app integration solution, CT Cloud Unite. ... and contact-orientated applications while using CT Cloud Voice and Skype for Business solutions. ...
(Date:4/8/2019)... ... April 09, 2019 , ... To ... research center Chan Zuckerberg Biohub (CZ Biohub) has chosen Geneious Biologics to help ... part of CZ Biohub’s efforts to establish new approaches to inform the discovery ...
(Date:4/4/2019)... ... April 03, 2019 , ... LeadingBiotech, an exclusive ... dialogue, today announces its Boston CEO conference to be held May 28-29, 2019 ... and opportunities with high-level panels and discussions from past, present and future change-makers. ...
Breaking Biology Technology:
Cached News: