HOME >> BIOLOGY >> NEWS
Growth disorder gene plays a big role in normal size variation

The presence of a small number of discrete forms - as you find in a classic Mendelian trait like eye color - suggests that the phenotype is controlled by a very small number of genes. In contrast, a complex trait such as body size is influenced by multiple genes as well as environmental factors, giving rise to a continuous spectrum of phenotypes. This causal complexity makes discovery of the genetic determinants of the trait - so-called quantitative trait loci (QTLs) - very difficult. In the open-access journal PLoS Biology, Fiona Oliver, Julian Christians, and colleagues extend their work on a single QTL with a large effect on body size variation in mice, and show that the responsible gene is one already linked to a Mendelian growth disorder in humans.

In this study, the authors further refined the map of a QTL on the X chromosome associated with a 20% difference in growth rate of mice, and found it contains only four genes: glypican-3 and glypican-4 (Gpc3 and Gpc4), and two other genes of unknown function. The glypicans are membrane-bound growth regulators; loss of function of Gpc3 in humans causes a rare syndrome of overgrowth, skeletal and other abnormalities, and neonatal death. In Gpc3, but not the others, size correlated with a significant difference in gene expression: larger mice had low levels of the messenger RNA, and smaller mice had high levels - the same pattern seen in the human loss-of-function disorder. The authors identified several non-coding polymorphisms in Gpc3 that differed between the two forms, although it remains to be seen whether the differential effect on growth is due to these or other DNA differences nearby.

The results from this study point out an important feature of inheritance, namely, that a gene implicated in a Mendelian trait can also contribute to quantitative variation. While catastrophic expression failure, such as a loss of function, can cause disease, smaller changes in expression of the same
'"/>

Contact: Paul Ocampo
pocampo@plos.org
415-624-1224
Public Library of Science
4-Apr-2005


Page: 1 2

Related biology news :

1. Growth factors and environment combine to increase brain maturation
2. Growth factor signals influence balance between normal growth and cancerous growth
3. Growth factor triggers growth of new blood vessels in the heart
4. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
5. Growth hormone is made in the brain, report scientists
6. Growth hormone, obesity can trigger sleep apnea in some kids
7. Growth in biomass could put US on road to energy independence
8. Growth factor in baby formula could reduce NEC, most devastating GI disease in preemies
9. Growth in the sea comes down to a struggle for iron
10. Growth of common skin cancer blocked in gene-switch mice
11. Growth factors confer immortality to sperm-generating stem cells

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Growth disorder gene plays big role normal size variation

(Date:7/30/2014)... is a subject of major interest in neuroscience. ... during the distinct stages of Wallerian degeneration: transcription ... dedifferentiation. Although gene expression responses in the distal ... injury are known, differences in gene expression between ... Dengbing Yao and co-workers from Nantong University, China ...
(Date:7/30/2014)... cells can develop into a multitude of cells types. Researchers ... the specific types of mature cells that make up the ... key seems to be long chains of sugars that dangle ... at the University of California, San Diego, has created synthetic ... can be more easily manipulated to direct the process, they ...
(Date:7/30/2014)... high-resolution map of the carbon stocks stored on ... new and improved methodology used to make the ... carbon economies. The new carbon map also ... provides the critical input to studies of deforestation ... enforcement purposes. The technique includes the determination of ...
Breaking Biology News(10 mins):Peru's carbon quantified: Economic and conservation boon 2Peru's carbon quantified: Economic and conservation boon 3
(Date:7/30/2014)... FRANCISCO , July 30, 2014 ... Congress evaluated the safety and efficacy of CSL ... rejection following kidney transplants in highly sensitized patients. ... inhibitor of the complement system. The ... in significant increases in the levels of complement ...
(Date:7/30/2014)... AZ (PRWEB) July 30, 2014 Sales ... the launch of blended sales training programs for companies ... sales training programs used by thousands of salespeople over ... blended sales training program can be customized to address ... , The blended sales training program consists ...
(Date:7/30/2014)... (PRWEB) July 30, 2014 Vycom announces ... of products, designed to meet Factory Mutual (FM) 4910 ... materials such as wet benches, process tools, fume hoods, ... safety and damage to semiconductor wafers used in electronic ... a flame-retardant PVC solution with excellent workability and superior ...
(Date:7/30/2014)... , July 30, 2014   Epic Sciences, ... and develops novel diagnostics to personalize and advance the ... of Gregory T. Lucier as chairman of ... and CEO of Life Technologies (formerly Invitrogen). Mr. Lucier ... Epic commercializes its circulating rare cell analysis platform with ...
Breaking Biology Technology:Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 2Study Suggests C1-INH May Aid in Prevention of Antibody-Mediated Rejection Following Kidney Transplant 3Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 2Sales Horizons Launches New Blended Sales Training Programs to Companies Engaged in Complex B2B Sales 3Vycom Announces Flametec® Thermax PVC (FM4910 Listed) For a Variety of Clean Room Applications with Excellent Workability and Aesthetics 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 2Epic Sciences Appoints Greg Lucier as Chairman of the Board of Directors 3
Cached News: