HOME >> BIOLOGY >> NEWS
Growth factor signals influence balance between normal growth and cancerous growth

For many biological processes, the Goldilocks Principle rules. You don't want too much, or too little, of something, you want it just right.

So it is with the body's delicate concentration of growth factors. Too much of a signaling protein called insulin-like growth factor-I (IGF-I) may fan the flames of cancer, while too little of the protein may cause short stature, dementia and osteoporosis, among other problems.

New research from The Children's Hospital of Philadelphia and the University of Pennsylvania School of Medicine deepens the understanding of how the growth hormone/IGF system is affected by another important actor: p53, the tumor suppressor gene that puts the brakes on cancer. The interplay of the two signaling pathways reinforces questions about the long-term risks of prescribing growth hormone and IGF-I to patients, at the same time that it may suggest a future new avenue for cancer therapy.

The study, which used cell cultures and mice, was published in the October issue of Cancer Biology & Therapy.

"It was already known that the tumor suppressor protein p53, which causes a cell to stop growing or to self-destruct, also acts on genes in the growth hormone/IGF axis to turn down IGF signaling," said pediatric endocrinologist and lead author Adda Grimberg, M.D., of The Children's Hospital of Philadelphia. "In this paper we showed that p53 increases production of insulin-like growth factor binding protein-2, an interaction that was not previously known." That protein, abbreviated as IGFBP-2, binds to IGF-I, and thus makes the growth factor less available to act on the body's tissues.

When the authors used genes to halt IGFBP-2 production by prostate cancer cells in culture, they found that p53 lost its ability to block IGF-I from activating one of its major signaling targets in those cells.

IGF-I is important because, along with naturally produced human growth hormone, it is the major regulato
'"/>

Contact: John Ascenzi
Ascenzi@email.chop.edu
267-426-6055
Children's Hospital of Philadelphia
9-Nov-2006


Page: 1 2 3

Related biology news :

1. Growth factors and environment combine to increase brain maturation
2. Growth factor triggers growth of new blood vessels in the heart
3. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
4. Growth hormone is made in the brain, report scientists
5. Growth hormone, obesity can trigger sleep apnea in some kids
6. Growth in biomass could put US on road to energy independence
7. Growth disorder gene plays a big role in normal size variation
8. Growth factor in baby formula could reduce NEC, most devastating GI disease in preemies
9. Growth in the sea comes down to a struggle for iron
10. Growth of common skin cancer blocked in gene-switch mice
11. Growth factors confer immortality to sperm-generating stem cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/27/2021)... ... March 25, 2021 , ... Phlexglobal announced ... Planet Group, has selected Phlexglobal and its innovative regulatory SaaS software, PhlexSubmission, as ... a comprehensive review of five regulatory software companies, with the review team including ...
(Date:3/27/2021)... ... 25, 2021 , ... The 2021 Virtual Conference on Clinical Trial Supply-Europe ... More and more, clinical trial supply conferences are featuring speakers and forums that ... Asymmetrex’s founder and CEO, James L. Sherley, M.D., Ph.D., presented a talk ...
(Date:3/23/2021)... ... March 23, 2021 , ... G-CON Manufacturing (G-CON), the ... by Matica Biotechnology (Matica Bio), a contract development and manufacturing organization (CDMO) specializing ... the cleanroom build out for its new GMP production facility in College Station, ...
Breaking Biology News(10 mins):
(Date:3/27/2021)... ... March 24, 2021 , ... ... Life Sciences and Healthcare firms of all sizes, adds depth to its team ... specialist. Pardillo, who earned his doctorate in computational chemistry from Florida International University ...
(Date:3/27/2021)... ... March 24, 2021 , ... ABI Wellness, ... and reporting approach designed under CEO Mark Watson, today announced a webinar dedicated ... featuring guest speakers Dr. Cameron Clark, Neuropsychologist and Founder of Sharp Thinking, and ...
(Date:3/27/2021)... ... ... The Xtalks editorial team is pleased to announce the launch of the ... joined by editorial team members Ayesha Rashid, Sydney Perelmutter and Mira Nabulsi to discuss ... including insights from industry experts. , The Xtalks Life Science podcast will feature ...
(Date:3/23/2021)... Conn. (PRWEB) , ... March 23, 2021 , ... ... develops solutions for characterizing microbiome populations down to the strain level, recently unveiled ... applications. , Not all microbes are created equal: some are easy to ...
Breaking Biology Technology:
Cached News: