HOME >> BIOLOGY >> NEWS
Growth factor triggers growth of new blood vessels in the heart

St. Louis, June 15, 2006 -- The newest concept for treating coronary artery disease is to induce hearts to grow their own new blood vessels to bypass damaged tissue or clogged arteries. Unfortunately, clinical trials of two important blood-vessel growth factors -- fibroblast growth factor 2 (FGF2) and vascular endothelial growth factor (VEGF) -- have not produced stellar results.

Now researchers at Washington University School of Medicine in St. Louis have investigated a third signaling molecule -- called Sonic hedgehog -- that could overcome problems associated with FGF2 and VEGF therapy.

In a report appearing in the June 15 issue of Genes and Development, the team showed that activating hedgehog signals in adult mouse hearts led to an increase in the density of blood vessels in the heart.

Their findings suggest that a drug treatment that turned on or increased hedgehog signals could provide substantial benefit to patients suffering from ischemic heart disease and myocardial infarctions and offer an alternative to invasive procedures like surgery or angioplasty.

About 12 percent of heart patients are not eligible for bypass surgery, which redirects blood around clogged arteries, or for other procedures routinely used to open clogged vessels. That means each year in the United States, 100,000 to 200,000 patients could benefit from having another option for improving blood flow in the heart, according to the study's authors.

"Our study is the first to identify that hedgehog signaling pathways are operational in the developing and mature heart," says senior author David Ornitz, M.D., Ph.D., the Alumni Endowed Professor of Molecular Biology and Pharmacology.

The hedgehog gene was discovered in fruit flies and named for the spiky appearance of fruit fly embryos with mutations of the gene.

"Hedgehog signaling is a good potential target for growing new vessels in the heart," says first author Kory Lavine, graduate student in molecula
'"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
15-Jun-2006


Page: 1 2

Related biology news :

1. Growth factors and environment combine to increase brain maturation
2. Growth factor signals influence balance between normal growth and cancerous growth
3. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
4. Growth hormone is made in the brain, report scientists
5. Growth hormone, obesity can trigger sleep apnea in some kids
6. Growth in biomass could put US on road to energy independence
7. Growth disorder gene plays a big role in normal size variation
8. Growth factor in baby formula could reduce NEC, most devastating GI disease in preemies
9. Growth in the sea comes down to a struggle for iron
10. Growth of common skin cancer blocked in gene-switch mice
11. Growth factors confer immortality to sperm-generating stem cells

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Growth factor triggers growth new blood vessels the heart

(Date:5/6/2015)... , May 6, 2015 LifeBEAM, a ... established helmet producer, announced today that they will expand ... the world,s first bio-sensing cycling helmet and the first ... in two new colors in order to give cyclists ... product. In addition, LifeBEAM and Lazer announced their plan ...
(Date:4/21/2015)... April 21, 2015 High ... policies are boosting access control systems market in ... to a recently published report by TechSci Research " ... the access control systems market in Saudi ... by 2020.The access control systems market in the Kingdom ...
(Date:4/14/2015)... NXT-ID, Inc. (NASDAQ: NXTD ) ("NXT-ID" ... the growing mobile commerce market, announces that its Wocket® ... York Design Awards under the category  ,Product Design – ... Awards are part of a global multi-disciplinary awards program. ... the marketplace, industry and judging panel. Winners will be ...
Breaking Biology News(10 mins):LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 2LifeBEAM and Lazer Announce Expanded Partnership in Bio-Sensing Sports Gear 3Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 2Saudi Arabia Access Control Systems Market to Touch USD1.2 Billion by 2020 Says TechSci Research 3NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 2NXT-ID's Wocket Smart Wallet Nominated for 2015 New York Design Awards in 'Product Design- Technology' 3
(Date:5/28/2015)... The Academy of Model Aeronautics Foundation will ... August 15, 2015. National Model Aviation Day was created to ... model flying to the general public. , The AMA has ... in the celebration by hosting events in their own communities. ... Aviation Day events. View our online event map to ...
(Date:5/28/2015)... May 28, 2015 Natera, Inc., a ... study published in Ultrasound in Obstetrics & ... (SNP)-based non-invasive prenatal test (NIPT) can identify a ... A study based upon data collected ... occur in about 1 in 1,000 pregnancies, although ...
(Date:5/28/2015)... TX (PRWEB) May 28, 2015 ... association serving and representing the life sciences industry ... Board of Directors meeting at The Foundry in ... of the organization brought together a broad spectrum ... and underscored the organization's early successes in partnering ...
(Date:5/28/2015)... , May 28, 2015 RXi Pharmaceuticals Corporation ... discovering and developing innovative therapeutics, primarily in the areas ... a public offering of 26 million units at a ... gross proceeds of approximately $10.4 million. Each unit consists ... 13-month overallotment purchase right to purchase 0.50 of a ...
Breaking Biology Technology:Model flying pilots celebrate the Academy of Model Aeronautics Foundation’s Third Annual National Model Aviation Day 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 2First Confirmed Detection of a Complete Molar Pregnancy with Cell-Free DNA Test 3BioNorthTX Holds Inaugural Board of Directors Meeting 2BioNorthTX Holds Inaugural Board of Directors Meeting 3RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 2RXi Pharmaceuticals Announces $10 Million Public Offering of Common Stock and Warrants 3
Cached News: