HOME >> BIOLOGY >> NEWS
Growth of common skin cancer blocked in gene-switch mice

Dr. Andrzej Dlugosz and colleagues at the University of Michigan and the National Cancer Institute have examined the functions of the Hedgehog (Hh) signaling pathway in basal cell carcinoma, the most common form of cancer, and have uncovered a subset of tumor cells that are resistant to inhibition of the Hh pathway. This new finding has important implications for the treatment of this widespread disease.

Their report is being released online tomorrow, in advance of its January 15th publication date by the journal Genes & Development (http://www.genesdev.org/cgi/doi/10.1101/gad.1258705).

Basal cell carcinoma (BCC) affects over 1,000,000 Americans each year and frequently arises on sun-exposed sites such as the face. Surgical removal of BCCs is an effective approach to treating these cancers, which generally have a slow growth rate and seldom metastasize. However, untreated BCCs can cause extensive local tissue damage, and surgical procedures can produce significant scarring in cosmetically sensitive locations such as the face.

The Hh signaling pathway plays a key role in normal development, and its dysfunction has been implicated in a number of different human diseases and neoplasms, including BCCs in skin and cancers arising in brain, lung, prostate, pancreas and other gastrointestinal organs. Dr. Dlugosz and colleagues focused on the function of uncontrolled Hh pathway signaling in the growth of BCC.

The investigators used genetically engineered mice in which they could manipulate expression of a Hh pathway component, called Gli2, effectively turning it on or off at will in the skin. As expected, expression of Gli2 resulted in BCC formation. In addition, the researchers found that sustained expression of Gli2 is necessary for the continued growth of these tumors. When Dr. Dlugosz and colleagues turned Gli2 off, the BCC tumor cells stopped growing and were elimi
'"/>

Contact: Heather Cosel
coselpie@cshl.edu
Cold Spring Harbor Laboratory
28-Dec-2004


Page: 1 2 3

Related biology news :

1. Growth factors and environment combine to increase brain maturation
2. Growth factor signals influence balance between normal growth and cancerous growth
3. Growth factor triggers growth of new blood vessels in the heart
4. Growth factor-promoting angiogenesis expressed in tumor cells and normal neurons
5. Growth hormone is made in the brain, report scientists
6. Growth hormone, obesity can trigger sleep apnea in some kids
7. Growth in biomass could put US on road to energy independence
8. Growth disorder gene plays a big role in normal size variation
9. Growth factor in baby formula could reduce NEC, most devastating GI disease in preemies
10. Growth in the sea comes down to a struggle for iron
11. Growth factors confer immortality to sperm-generating stem cells

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/4/2020)... ... July 03, 2020 , ... Aesthetics ... recognition and multiple awards for not only the products and treatments developed, but ... and Vivace® Microneedle RF. All the brands built by ABM have received several ...
(Date:7/1/2020)... ... July 01, 2020 , ... Catalent, a global leader in ... Pharmaceuticals’ packaging facility in Minakuchi, located in the Shiga prefecture of Japan. , ... Kakegawa, the new 60,000-square-foot facility will provide customers with flexible clinical supply solutions, ...
(Date:6/28/2020)... Fla. (PRWEB) , ... June 25, 2020 , ... In ... focus on innovations in accelerated Point of Care Testing solutions (POCT). Check local listings ... Samples are collected at medical offices and are shipped to labs throughout the country. ...
Breaking Biology News(10 mins):
(Date:6/28/2020)... ... June 26, 2020 , ... The ... providers, today announced its strong opposition to the recently introduced bicameral Facial ... blanket ban on most federal use of nearly all biometric and related image ...
(Date:6/23/2020)... ... June 22, 2020 , ... Regen Suppliers, the ... This includes buy three, get the fourth unit free with no limit on ... exosomes, known as exosomes, have been a game changer for regenerative therapies. The ...
(Date:6/19/2020)... , ... June 18, 2020 , ... The Vitaspace ... goal is to join forces to radically prolong life and find a way (medicine ... aging period. This project was supported by various scientists from all over the world, ...
(Date:6/11/2020)... , ... June 09, 2020 , ... ... release of the NEON Micro-Tracer Solution, a highly accurate, contact tracing ... virus in the workplace. Contact tracing, a core disease control measure, is a ...
Breaking Biology Technology:
Cached News: