HOME >> BIOLOGY >> NEWS
HIV-1 kills immune cells in the gut that may never bounce back

People with HIV have been living longer, healthier lives since the development of highly active antiretroviral therapy (or HAART) in 1995. In fact, most patients on the drug regimen do so well that, according to blood tests, their immune cells appear to return to pre-HIV levels. But two new studies from Rockefeller University and the Aaron Diamond AIDS Research Center (ADARC) show that the immune cells in other body tissues may never rebound, suggesting the need for additional ways to monitor immune system health, and the need for hypervigilance as HIV-positive patients live into their forties, fifties, sixties and beyond. The findings are reported in today's issue of PLoS Medicine and online in the Journal of Virology.

Prior research had shown that, just two to four weeks after contracting HIV-1, the lymphoid tissue layer in the mucous membrane of a patient's gastrointestinal (GI) tract can lose up to 60 percent of its CD4 memory T cells -- immune cells responsible for recognizing invaders and priming other cells for attack. Intrigued, Martin Markowitz, an Aaron Diamond Professor at Rockefeller University and a staff scientist at ADARC, wanted to know whether this loss was reversible, and whether giving patients HAART during the early infection period helped restore these cells to the GI lining the way it restored them to the blood itself.

In a paper published today in PLoS Medicine, Markowitz, Rockefeller researcher and clinical scholar Saurabh Mehandru, and their colleagues report on a trial of 40 HIV-1 positive patients who began treatment with HAART shortly after contracting the virus -- during the acute early infection phase -- and who they followed from one to seven years. The researchers found that although the blood population of CD4 T cells rebounded to normal levels, a subset of the GI tract population remained depleted in 70 percent of their subjects.

"If we sample the blood, it only has two percent of the total volume
'"/>

Contact: Kristine Kelly
kkelly@rockefeller.edu
212-327-7146
Rockefeller University
4-Dec-2006


Page: 1 2 3

Related biology news :

1. Researchers discover new details about HIV-1 entry and infection
2. Human testis harbors HIV-1 in resident immune cells
3. A new player in nuclear import of HIV-1
4. Case Western Reserve University chemist takes on HIV-1 virus with $1M support from NIH
5. HIV-1s high virulence might be an accident of evolution
6. UAB researchers confirm HIV-1 originated in wild chimpanzees
7. Novel protein in St. Johns Wort found to suppress HIV-1 gene expression
8. Ancient immune defense mechanism is no match for HIV-1
9. Research advances quest for HIV-1 vaccine
10. IL-7 wipes out HIV-1 hideouts
11. Fat kills cancer

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/4/2017)... YORK , April 4, 2017   EyeLock ... today announced that the United States Patent and Trademark ... patent broadly covers the linking of an iris image ... same transaction) and represents the company,s 45 th ... latest patent is very timely given the multi-modal biometric ...
(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
(Date:3/30/2017)... 2017 Trends, opportunities and forecast in this ... technology (fingerprint, AFIS, iris recognition, facial recognition, hand geometry, ... end use industry (government and law enforcement, commercial and ... and others), and by region ( North America ... Asia Pacific , and the Rest of the ...
Breaking Biology News(10 mins):
(Date:9/20/2017)... Station, TX (PRWEB) , ... ... ... Services, LLC (IPS), a leading global provider of engineering, architecture, project controls, ... provider of prefabricated cleanrooms, today announced the unveiling of the iCON™ brand ...
(Date:9/20/2017)... ... September 20, 2017 , ... RoviSys, a leading independent provider ... opening of an office in Taipei, Taiwan. This new location allows RoviSys to ... new relationships in the region. Located in the Neihu area of Taipei, the ...
(Date:9/19/2017)... ... September 19, 2017 , ... The new and improved Oakton® pocket testers, ... even stand upright with a new cap design that is versatile, functional and leakproof. ... who need to test water quality. , The Oakton pocket testers have many user-friendly ...
(Date:9/19/2017)... (PRWEB) , ... September 19, ... ... York State Department of Financial Services (NYS DFS) cybersecurity regulations have ... banking, finance and insurance organizations operating in the state (“Covered Entities”) to ...
Breaking Biology Technology:
Cached News: