HOME >> BIOLOGY >> NEWS
HIV protein enlisted to help kill cancer cells

Cancer cells are sick, but they keep growing because they don't react to internal signals urging them to die. Now researchers at Washington University School of Medicine in St. Louis have found an efficient way to get a messenger into cancer cells that forces them to respond to death signals. And they did it using one of the most sinister pathogens around HIV.

"HIV knows how to insert itself into many different types of cells," says senior author William G. Hawkins, M.D., assistant professor of surgery and a member of the Siteman Cancer Center at the School of Medicine and Barnes-Jewish Hospital. "A portion of the HIV protein called TAT can transport biologically active compounds into cells. TAT is small, but it can move massive molecules. You could almost hook TAT up to a train, and TAT would drag it inside a cell. So we've taken advantage of this ability."

In an article published online in January 2007 in the Annals of Surgical Oncology, the researchers describe using TAT to pull a protein called Bim into cancer cells. TAT alone cannot cause AIDS and has no adverse health effects. Bim acts as a tumor suppressor and causes cancer cells to die through apoptosis, a process by which cells "commit suicide."

The research team found that the TAT-Bim compound activated apoptosis mechanisms in cancer cells and augmented the cell-killing effect of radiation. When mice with malignant tumors were treated with TAT-Bim, their tumors shrank, and they survived longer than mice that didn't get the treatment. After 40 days, 80 percent of mice receiving TAT-Bim were alive compared to 20 percent of mice that didn't get the treatment.

Hawkins asserts that this success marks the beginning of a very promising new approach to cancer therapy. "This is the tip of the iceberg," he says. "Now that we've proven we can do this, we've started creating a battery of proteins that can push cancer cells to die."

Hawkins says he thinks treatments that activate apoptosis
'"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
15-Feb-2007


Page: 1 2 3

Related biology news :

1. Penn researchers discover how key protein stops inflammation
2. UCF research links proteins, stem cells and potential Alzheimers treatment
3. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
4. Discovery of new protein could provide new understanding of male fertility
5. Unlocking proteins from their cellular shell
6. Altering a protein makes mice less fearful
7. New research identifies anti-viral protein that may predict who might be at risk to develop lupus
8. MicroRNA works with Ago2 protein to regulate blood cell development
9. Carnegie Mellon scientists find key HIV protein makes cell membranes bend more easily
10. Call for EU to launch major project to map out all our proteins
11. New role for protein in fat cells may improve understanding of obesity and diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/22/2020)... ... April 20, 2020 , ... RCH Solutions (RCH ), ... all sizes, announces the hiring of Michael Wlodarczyk as Director of Sales and Business ... support and grow the company’s already strong presence across the Northeast. , “We continue ...
(Date:4/22/2020)... ... April 21, 2020 , ... USDM Life Sciences , ... announces a new managed service to improve quality management for regulated companies, Unify ... USDM Life Sciences (USDM) – Unify Compliance Cloud is a suite of applications ...
(Date:4/18/2020)... CAMBRIDGE, Mass. (PRWEB) , ... April 16, 2020 , ... ... for gene and cell therapy, today announced it will present a company update on ... 2020 Virtual Investor Summit taking place on April 22 and 23. Dieter Lingelbach, ...
Breaking Biology News(10 mins):
(Date:5/15/2020)... ... ... Sentien Biotechnologies, Inc., a clinical-stage biotechnology company developing novel approaches to cell ... will continue to lead Sentien’s Board of Directors, a role he has filled for ... Sentien’s management team. , Mr. Ganz has more than 30 years of ...
(Date:5/14/2020)... FRANCISCO (PRWEB) , ... May 13, 2020 , ... ... content hub called Future Lab: Optimizing Workflows in the Life Science Lab ... optimize workflows in their lab, from water purification and liquid handling to contamination ...
(Date:5/5/2020)... ... May 04, 2020 , ... Red Nucleus, ... sciences industry, today announced that Informa Training Partners, a life sciences training company ... Red Nucleus Boston, effective immediately. , “The name change solidifies a stronger presence ...
(Date:5/1/2020)... ... April 30, 2020 , ... The winners ... businesses, policies, projects, and concepts that are actively engaged and deeply committed to ... which has taken out the top prize in the Experimental category. , The ...
Breaking Biology Technology:
Cached News: