HO-1 in sickle cell disease: friend or foe?

Rochester, Minnesota -- Researchers have unexpectedly shown that sickle cell-associated kidney injury may be reduced by inhibiting the enzyme activity of a protein that commonly confers protection in other diseased states. The paper by Juncos et al., "Anomalous renal effects of tin protoporphyrin in a murine model of sickle cell disease," appears in the July issue of The American Journal of Pathology.

Sickle cell disease (SCD), which affects greater than 70,000 individuals in the US, is an inherited hemoglobin disorder that causes some red blood cells to lose their smooth round shape and assume a crescent, or sickle, shape. Sickle cells can become lodged in small capillary blood vessels, with blockage of blood flow leading to pain, stroke, and damage to most organs including the lungs, spleen, kidneys and liver.

The mechanisms underlying SCD-associated kidney disease include various forms of secondary stress, such as changes in internal kidney blood flow, induction of oxidative injury, and influx of inflammatory cells. Researchers have thought that cells combat such stress through expression of heme oxygenase-1 (HO-1), a protective enzyme that is upregulated in SCD kidneys in humans and in mouse models. New research, however, suggests that in SCD HO-1 may not be as protective as previously thought.

In an attempt to understand the specific role of HO-1 in kidney injury, Juncos et al. examined SCD mice in the presence or absence of tin protoporphyrin (SnPP), a widely accepted inhibitor of the enzyme activity of HO. Short-term SnPP treatment successfully blocked HO activity in both normal and SCD mice, reduced kidney blood flow in normal and SCD mice, but did not affect the filtration capacity of the kidney in either group. However, when chronically administered, SnPP caused inflammation and fibrosis (scarring) in normal mice but not in SCD mice; in normal mice, SnPP induced genes related to fibrosis and inflammation, whereas in SCD

Contact: Audra Cox
American Journal of Pathology

Page: 1 2

Related biology news :

1. Leaders in sickle cell research meet in Cincinnati
2. Discovery promises simpler therapy for sickle cell disease
3. UNC scientists identify sticky protein in sickle cell red blood cells
4. A close-up on pancreatic disease: How do we improve the odds?
5. Spotlight on liver disease: Improving todays treatments
6. Polycystic kidney disease: MRI provides an early alert to progression
7. A new view on Lyme disease: Rodents hold the key to annual risk
8. New insight into autoimmune disease: Bacterial infections promote recognition of self-glycolipids
9. Psychological stress and disease: UCSF-led study suggests connection
10. A friendly foe -- Bacteria residing in the gut boost immune response to tumors
11. When the villain becomes your friend: The strange tale of muscle lactate

Post Your Comments:

(Date:9/8/2019)... Md. (PRWEB) , ... September ... ... biotechnology market disrupter and leading supplier of innovative human mesenchymal stem/stromal cell ... first human umbilical cord (hUC) MSC paired cell and media system designed ...
(Date:8/29/2019)... Calif. (PRWEB) , ... August ... ... daacro (Diagnostic Assessment and Clinical Research Organization), have recently passed their ... CRO standards, hormone diagnostics and psychoneuroendocrine stress expertise, with a primary focus ...
(Date:8/25/2019)... ... August 23, 2019 , ... Sierra Instruments is pleased to announce ... online store are now live. Sierra has redesigned entry to the site with both ... more user-friendly and easier to navigate with streamlined menus and simple access to resources ...
Breaking Biology News(10 mins):
(Date:9/9/2019)... ... ... Visikol CEO Dr. Michael Johnson recently gave a talk at the ... cell culture models. The inherent problem of characterizing 3D cell culture models is similar ... and therefore traditional wide-field or even confocal microscopy only tells you what is going ...
(Date:9/2/2019)... ... September 02, 2019 , ... ... in vitro diagnostics, has launched the industry’s first epigenetics data mining services that ... of epigenetic data and other data types. , Next generation sequencing in combination ...
(Date:8/27/2019)... ... ... Dr. Kim Carlson is a veterinary surgeon practicing in the bay area of ... new surgical practice in San Mateo. She is currently the only surgeon in ... the practice grows. , When asked about the opening of her new surgical practice, ...
(Date:8/23/2019)... ... August 22, 2019 , ... An ... and is scheduled to broadcast 4Q/2019. Check your local listings for more information. ... for generic drug delivery. Focusing on therapeutics for children and the elderly, viewers ...
Breaking Biology Technology:
Cached News: