HOME >> BIOLOGY >> NEWS
HPV testing finds precancerous lesions at a higher rate than conventional pap smears

Human papillomavirus (HPV) testing was more sensitive than traditional Pap smears at detecting precancerous lesions of the cervix, a study in the June 7 issue of the Journal of the National Cancer Institute reports. A new, liquid-based form of the Pap test marginally improved sensitivity but also produced more false positives.

Previous studies have shown that searching for a precancerous cervical lesion called cervical intraepithelial neoplasia with an HPV test is more sensitive but also has more false positives than conventional pap smears, where doctors look for abnormal cells on a slide. Despite the widespread use of newer Pap technology called liquid-based cytology, where doctors first immerse the Pap sample in a solution before looking at the cells, its accuracy is not clearly defined. Some scientists suggest there is a need to understand what combination of tests increases sensitivity while keeping the number of false positives acceptable.

Guglielmo Ronco, M.D., Ph.D., of CPO Piemonte in Torino, Italy, and colleagues set up a randomized controlled trial that screened over 33,000 women for cervical cancer, half with conventional pap smears and the other half with HPV tests and liquid-based cytology. Women with abnormal cells from either Pap test or a positive HPV result were further examined by a technique called colposcopy, where doctors use a magnifying instrument to get a detailed view of the cervix.

The authors found that HPV testing combined with liquid-based cytology led to a 47% increase in sensitivity compared to conventional pap smears, but increased the chance of false positives by 60%. HPV testing alone increased sensitivity by more than 40%, with a smaller decrease in specificity (25% or 42%, depending on the type of test used). Liquid-based cytology did not show greater sensitivity than conventional pap smears, but increased the number of false positives.

The authors write, "HPV testing alone was more sensit
'"/>

Contact: Ariel Whitworth
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
6-Jun-2006


Page: 1 2

Related biology news :

1. Modular leukemia drug shows promise in early testing
2. Rapid syphilis testing in Haiti will prevent congenital disease and stillbirths
3. XDx to present recent success with AlloMap molecular expression testing
4. Potential genetic testing for substance abuse raises hope, concern
5. U-M team: Genetic testing sheds light on degenerative eye disease
6. Antiretroviral resistance testing in HIV infected patients improves health and saves costs
7. Professors to develop hand-held pathogen testing device
8. Animal testing alternative has ticks trembling at the knees
9. New research to cut animal testing
10. New method of testing eggs for abnormalities could solve problems of embryo freezing
11. Education and guidelines needed for genetic testing in liver disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2018)... ... , ... With increasing safety requirements, and time and financial pressure, the development ... To be successful in such a competitive environment, it is more important than ever ... needed to develop a new drug or to execute fundamental research. , In ...
(Date:8/15/2018)... ... August 15, 2018 , ... The Florida Chiropractic Association’s National Meeting ... Doctors from around the U.S. will gain firsthand insights into the new laser’s ... completed another successful clinical trial that has resulted in the granting of an ...
(Date:8/14/2018)... ... August 13, 2018 , ... Castle Dental® has partnered ... office on South Lamar Blvd. to provide free dental services for underinsured, low-income ... include x-rays and exams, fillings , extractions , cleanings ...
Breaking Biology News(10 mins):
(Date:7/31/2018)... , ... July 31, 2018 , ... ... for 65 years, announces the launch of their new website. The new website ... experience throughout the site. Mahoney partnered with Proceed Innovative to build a website ...
(Date:7/25/2018)... ... July 25, 2018 , ... ... energy treated proprietary nutraceutical to combat inflammation and autoimmune disorders. , The ... function response. The following data was reported:, Over ...
(Date:7/25/2018)... ... July 25, 2018 , ... John McDonald, CEO ... board of the Indiana India Business Council (IIBC), an advocacy group to strengthen ... current board of directors, McDonald joins an impressive roster of local and national ...
(Date:7/24/2018)... ... July 24, 2018 , ... On August 6, ... SmartTRAK platform. Not just a pretty face, SmartTRAK 3.0’s latest improvements were ... SmartTRAK is the world’s first online and real-time data portal that specializes in ...
Breaking Biology Technology:
Cached News: