HOME >> BIOLOGY >> NEWS
HPV testing finds precancerous lesions at a higher rate than conventional pap smears

Human papillomavirus (HPV) testing was more sensitive than traditional Pap smears at detecting precancerous lesions of the cervix, a study in the June 7 issue of the Journal of the National Cancer Institute reports. A new, liquid-based form of the Pap test marginally improved sensitivity but also produced more false positives.

Previous studies have shown that searching for a precancerous cervical lesion called cervical intraepithelial neoplasia with an HPV test is more sensitive but also has more false positives than conventional pap smears, where doctors look for abnormal cells on a slide. Despite the widespread use of newer Pap technology called liquid-based cytology, where doctors first immerse the Pap sample in a solution before looking at the cells, its accuracy is not clearly defined. Some scientists suggest there is a need to understand what combination of tests increases sensitivity while keeping the number of false positives acceptable.

Guglielmo Ronco, M.D., Ph.D., of CPO Piemonte in Torino, Italy, and colleagues set up a randomized controlled trial that screened over 33,000 women for cervical cancer, half with conventional pap smears and the other half with HPV tests and liquid-based cytology. Women with abnormal cells from either Pap test or a positive HPV result were further examined by a technique called colposcopy, where doctors use a magnifying instrument to get a detailed view of the cervix.

The authors found that HPV testing combined with liquid-based cytology led to a 47% increase in sensitivity compared to conventional pap smears, but increased the chance of false positives by 60%. HPV testing alone increased sensitivity by more than 40%, with a smaller decrease in specificity (25% or 42%, depending on the type of test used). Liquid-based cytology did not show greater sensitivity than conventional pap smears, but increased the number of false positives.

The authors write, "HPV testing alone was more sensit
'"/>

Contact: Ariel Whitworth
jncimedia@oxfordjournals.org
301-841-1287
Journal of the National Cancer Institute
6-Jun-2006


Page: 1 2

Related biology news :

1. Modular leukemia drug shows promise in early testing
2. Rapid syphilis testing in Haiti will prevent congenital disease and stillbirths
3. XDx to present recent success with AlloMap molecular expression testing
4. Potential genetic testing for substance abuse raises hope, concern
5. U-M team: Genetic testing sheds light on degenerative eye disease
6. Antiretroviral resistance testing in HIV infected patients improves health and saves costs
7. Professors to develop hand-held pathogen testing device
8. Animal testing alternative has ticks trembling at the knees
9. New research to cut animal testing
10. New method of testing eggs for abnormalities could solve problems of embryo freezing
11. Education and guidelines needed for genetic testing in liver disease

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/16/2018)... ... October 16, 2018 , ... Our own cells may be the answer to ... So comments interventional spine and pain management specialist Jason Arora, DO, who says using ... cells harvested from a patient’s bone marrow are proving effective therapies for eliminating discogenic ...
(Date:10/16/2018)... ... October 16, 2018 , ... Nanomedical Diagnostics , ... new publication titled, “ Graphene-based Biosensor for On-Chip Detection of Bio-Orthogonally Labeled Proteins ... as a “new portable digital device for biosensing… that can be employed for ...
(Date:10/13/2018)... ... 12, 2018 , ... uBiome, the leader in microbial genomics, ... its Medical Advisory Board. Joining the board of leading scientists and doctors from ... the surgical treatments of ulcerative colitis and Crohn's disease. The appointment will help ...
Breaking Biology News(10 mins):
(Date:10/5/2018)... ... October 04, 2018 , ... Karius , a ... announced today at IDWeek™ 2018 the positive results of a study demonstrating that ... accurately identified causative pathogens in patients with infective endocarditis even when blood cultures ...
(Date:10/3/2018)... ... ... Milwaukee Area Technical College (MATC), a public, two-year comprehensive technical college, will ... T129 in the T Building, 101 N. 6th St., to introduce area students, educators, ... formal program will be held at 4 p.m. , MATC recently added new state-of-the ...
(Date:10/2/2018)... Calif. (PRWEB) , ... October 02, 2018 , ... ... Undetected or ignored, contamination endangers the reliability and reproducibility of experimental data. Each ... contamination. , In this educational webinar, which is sponsored by Eppendorf , ...
(Date:9/28/2018)... ... September 28, 2018 , ... GlycoMark®, Inc. has ... of the GlycoMark test, the only FDA-cleared blood test specific to detecting recent ... promote and offer the GlycoMark test to its network of physicians through its ...
Breaking Biology Technology:
Cached News: