HOME >> BIOLOGY >> NEWS
HYPER-CEST MRI breaks new ground in molecular imaging

T technology, which was developed as a contrast method for boosting the MRI contrast from protons. CEST is based on the exchange of protons that takes place between water molecules and other molecules in the body. (Approximately 60-percent of the human body and 90-percent of the blood is water.) During an MRI session, these exchanging protons can be selectively labeled with the RF pulse. Comparing MRI images taken with and without CEST labeling yields images with meaningful bright contrasts. While effective under certain conditions, CEST is limited by the fast relaxation time of protons, which necessitates the need for large magnetic fields to decrease relaxation effects and increase the difference between saturated and non-saturated MRI signals. It also requires a relatively large amount of the CEST agent to generate significant contrast enhancement.

Hyperpolarized xenon has a much longer relaxation time than protons, which means that the enhanced MRI signal is not only stronger, but lasts much longer. The MRI signal obtained directly from the xenon biosensors is hundreds of times smaller than the easily detected signal obtained from a pool of free xenon dissolved in the rest of the sample. The HYPER-CEST images are based on the free xenon signal rather than direct detection of the biosensors which leads to the high sensitivity of the technique.

Another huge advantage, as Lowery explained, is that "there is no xenon naturally present in body, so we don't have to fish out a small change in an MRI signal with a high background like other MRI contrast agents. In that sense, HYPER-CEST is more like a PET (Positron Emission Tomography) probe. Because multiple xenon biosensors can be used to detect different targets at the same time, HYPER-CEST is also like quantum dots, where different colors of dots can be used to simultaneously report different analytes. However, unlike quantum dots, our xenon agents can be detected deep within the body."


'"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
19-Oct-2006


Page: 1 2 3 4 5 6 7

Related biology news :

1. No magic tomato? Study breaks link between lycopene and prostate cancer prevention
2. Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
3. Ebola outbreaks killing thousands of gorillas and chimpanzees
4. Lost cuckoo breaks its silence
5. Mathematical model predicts cholera outbreaks
6. UGA study underscores importance of rapid reponse in curtailing disease outbreaks
7. Genetic repair mechanism clears the way for sealing DNA breaks
8. New study shows how genetic repair mechanism helps seal DNA breaks
9. New textbook uses real disease outbreaks to teach undergraduate microbiology
10. New treatment option breaks Leukemias resistance to chemotherapy, radiation therapy
11. Study finds key distinction between outbreaks that die out and epidemics

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/14/2017)... June 15, 2017  IBM (NYSE: IBM ) is introducing ... event dedicated to developing collaboration between startups and global businesses, ... 15-17. During the event, nine startups will showcase the solutions ... various industries. France ... market, with a 30 percent increase in the number of ...
(Date:5/16/2017)... 16, 2017  Veratad Technologies, LLC ( www.veratad.com ), ... and identity verification solutions, announced today they will participate ... May 15 thru May 17, 2017, in ... Trade Center. Identity impacts the lives ... today,s quickly evolving digital world, defining identity is critical ...
(Date:5/6/2017)... 5, 2017 RAM Group , ... new breakthrough in biometric authentication based on a ... properties to perform biometric authentication. These new sensors are ... created by Ram Group and its partners. This sensor ... supply chains and security. Ram Group is a ...
Breaking Biology News(10 mins):
(Date:9/22/2017)... ... September 22, 2017 , ... Precision Periodontics and Implant ... and LAPIP™ laser treatments. Drs. Hoge and Zalewsky are members of an elite ... and less painful option that produces real results. , "Like many of my ...
(Date:9/22/2017)... ... 2017 , ... The effectiveness of a new wound healing ... in the United States. (clinicaltrials.gov : NCT02973893) , To find out more about ... nearest participating clinic here https://factor-therapeutics.com/clinical-trials/ and discuss your condition with one ...
(Date:9/21/2017)... ... ... Dr. Greg Leyer, Chief Scientific Officer of UAS Labs, will be presenting at ... in the Probiotics Resource Center, Mandalay Bay Expo Hall. , “I am very ... shown impressive data in areas outside the gut including heart health, Vitamin D status, ...
(Date:9/21/2017)... ... September 21, 2017 , ... Colpitts Clinical ... of the portal includes new features that facilitate streamlined and compliant communication, file ... remain at the forefront of medical advancements, they rely on efficiencies to help ...
Breaking Biology Technology:
Cached News: