HOME >> BIOLOGY >> NEWS
HYPER-CEST MRI breaks new ground in molecular imaging

T technology, which was developed as a contrast method for boosting the MRI contrast from protons. CEST is based on the exchange of protons that takes place between water molecules and other molecules in the body. (Approximately 60-percent of the human body and 90-percent of the blood is water.) During an MRI session, these exchanging protons can be selectively labeled with the RF pulse. Comparing MRI images taken with and without CEST labeling yields images with meaningful bright contrasts. While effective under certain conditions, CEST is limited by the fast relaxation time of protons, which necessitates the need for large magnetic fields to decrease relaxation effects and increase the difference between saturated and non-saturated MRI signals. It also requires a relatively large amount of the CEST agent to generate significant contrast enhancement.

Hyperpolarized xenon has a much longer relaxation time than protons, which means that the enhanced MRI signal is not only stronger, but lasts much longer. The MRI signal obtained directly from the xenon biosensors is hundreds of times smaller than the easily detected signal obtained from a pool of free xenon dissolved in the rest of the sample. The HYPER-CEST images are based on the free xenon signal rather than direct detection of the biosensors which leads to the high sensitivity of the technique.

Another huge advantage, as Lowery explained, is that "there is no xenon naturally present in body, so we don't have to fish out a small change in an MRI signal with a high background like other MRI contrast agents. In that sense, HYPER-CEST is more like a PET (Positron Emission Tomography) probe. Because multiple xenon biosensors can be used to detect different targets at the same time, HYPER-CEST is also like quantum dots, where different colors of dots can be used to simultaneously report different analytes. However, unlike quantum dots, our xenon agents can be detected deep within the body."


'"/>

Contact: Lynn Yarris
lcyarris@lbl.gov
510-486-5375
DOE/Lawrence Berkeley National Laboratory
19-Oct-2006


Page: 1 2 3 4 5 6 7

Related biology news :

1. No magic tomato? Study breaks link between lycopene and prostate cancer prevention
2. Baumann Lab defines proteins that distinguish chromosome ends from DNA double-strand breaks
3. Ebola outbreaks killing thousands of gorillas and chimpanzees
4. Lost cuckoo breaks its silence
5. Mathematical model predicts cholera outbreaks
6. UGA study underscores importance of rapid reponse in curtailing disease outbreaks
7. Genetic repair mechanism clears the way for sealing DNA breaks
8. New study shows how genetic repair mechanism helps seal DNA breaks
9. New textbook uses real disease outbreaks to teach undergraduate microbiology
10. New treatment option breaks Leukemias resistance to chemotherapy, radiation therapy
11. Study finds key distinction between outbreaks that die out and epidemics

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: HYPER CEST MRI breaks new ground molecular imaging

(Date:10/29/2014)... October 27, 2014 — Cambridge, MA and Hebei, China ... the complete, high quality sequencing of the Jujube genome. ... Rhamnaceae family, and the Jujube genome is particularly difficult ... other complicating factors. It is the first time that ... sequenced. This study has been recently published in ...
(Date:10/29/2014)... Genomics of the Kidney consortium ( CAGEKID ) ... exposure to aristolochic acid, an ingredient in some ... Communications , have important implications for public health. ... every year, and in Central Europe incidence rates ... International Cancer Genome Consortium (ICGC), has been studying ...
(Date:10/28/2014)... German . ... sufficient food when times are lean? By studying wild ... researchers of the Max Planck Institute for Evolutionary Anthropology ... great apes can acquire extra energy needed to maintain ... sleeping nests more en route to breakfast sites containing ...
Breaking Biology News(10 mins):BGI Tech and Hebei Agricultural University complete the genome sequencing of the jujube tree 2Kidney cancer in Central Europe 2The early chimp gets the fig 2The early chimp gets the fig 3
(Date:10/27/2014)... 2014 The report “Smart Highway ... Management, Communication, Monitoring), and by Display (Variable Message ... segments the global market into various sub-segments with ... identifies the drivers and restraints for this market ... Browse 75 market tables and 37 figures spread ...
(Date:10/27/2014)... Pa. , Oct. 27, 2014 ... Foundation of America (CCFA) announced today the launch ... , an educational campaign designed to ... diseases (IBD) on the paired role of nutrition ... To view the multimedia assets associated with this ...
(Date:10/26/2014)... The report "Data Center Networking Market ... WAN Optimization Appliances]: Global Advancements, Worldwide Forecasts & ... networking market into various segments with an in-depth ... identifies the factors driving this market, various restraints ... the future roadmaps. , Browse 106 market data ...
(Date:10/25/2014)... 2014 The report “Adipic Acid ... Geography - Global Trends & Forecast to 2019” ... to market drivers, opportunities, and trends in different ... 27 figures spread through 217 slides and in-depth ... & Forecast to 2019”., http://www.marketsandmarkets.com/Market-Reports/adipic-acid-269.html , Early ...
Breaking Biology Technology:Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 2Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 3Smart Highway Market by Technology, and Display Expected to Reach $27.992.0 Million by 2019- New Report by MarketsandMarkets 4Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 2Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 3Celebrity Cook Sunny Anderson Teams Up With Janssen And Crohn's & Colitis Foundation Of America To Launch Educational Campaign 4Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 2Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 3Data Center Networking Market by Ethernet Switches, SAN & Routers Worth $21.85 Billion by 2018 - New Report by MarketsandMarkets 4Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 2Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 3Adipic Acid Market Estimated to Grow $7,539.2 Million by 2019 - Report by MarketsandMarkets 4
Cached News: