HOME >> BIOLOGY >> NEWS
Handicapping tuberculosis may be the way to a better vaccine

Howard Hughes Medical Institute investigator William R. Jacobs and colleagues have produced a genetically altered strain of tuberculosis (TB) that elicits a stronger immune response than the current vaccine, bacillus Calmette-Gurin (BCG). The new vaccine improves survival of infected animals and may help put scientists on track to replace BCG, which has been used for nearly a century although it is largely ineffective.

Despite widespread vaccination programs, the World Health Organization estimates that approximately 2 billion people worldwide are infected with TB, with over 95 percent of infections occurring in developing countries. Most TB is latent, but can become active when the immune system is weak, such as during HIV infection, and more than 1.6 million die each year from this disease. In addition, resistance to current treatments is becoming increasingly common, making an effective vaccine all the more crucial.

Were very excited because this is the first vaccine strain weve ever seen that is significantly better than BCG, said Jacobs.

Jacobs worked in collaboration with Steven Porcelli at the Albert Einstein College of Medicine. The team will publish its findings in the August, 2007, issue of the Journal of Clinical Investigation.

The immune system has a very difficult time detecting and combating Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By creating a strain of TB that behaves differently, Jacobs believes he can build a vaccine that prepares the body to recognize TB when infected.

If a cell becomes aware that a pathogen has invaded, it can prevent the infection from spreading to other cells by committing cell suicidea process known as apoptosis, where the cell shuts down and is shredded into little pieces.

Immune system cells further chop up these cellular bits and present them to white blood cells called T lymphocytes. Each T lymphocyte specifically recognizes a different sma
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
1-Aug-2007


Page: 1 2 3

Related biology news :

1. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
2. Developing a more effective vaccine for tuberculosis
3. Why is long-term therapy required to cure tuberculosis?
4. UA researchers identify new adherence factor, Pili, produced by tuberculosis
5. Shorter tuberculosis therapies could lead to substantial reductions in cases and deaths
6. Pitt phage hunter takes on tuberculosis
7. Cost-effectiveness of treating multidrug-resistant tuberculosis
8. New potential drug target in tuberculosis
9. National Institutes of Health funds $13.7 million for Texas tuberculosis study
10. Einstein researchers find potential new drugs for tuberculosis
11. Studies suggest new targets for tuberculosis treatments

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/2/2017)... Summary This report provides all the information ... partnering interests and activities since 2010. Download the ... Deals and Alliance since 2010 report provides an in-depth ... world,s leading life sciences companies. On demand ... of the most up to date deal and company ...
(Date:2/28/2017)... 2017   Acuant , a leading provider of ... enhancements to new and core technologies building upon the ... mobile and desktop Acuant FRM TM facial recognition ... real time manual review of identity documents by accredited ... fastest and most accurate capture software to streamline workflows ...
(Date:2/26/2017)... 2017  Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring, announces the appointment ... "Too often, too many offenders return to ... are trying to tackle this ongoing problem and ... family members. While significant steps are underway, Securus continues ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... at a Marketing Roundtable on March 22 in Philadelphia. The event was offered ... , The Marketing Roundtable featured breakout groups and interaction with speakers ...
(Date:3/28/2017)... WASHINGTON , March 28, 2017  (AACR17, ... single-cell sequencing during the American Association for Cancer Research ... Center in Washington, D.C. , April ... gene expression of thousands of cells at the individual ... Experts on-hand at AACR to discuss expanded ...
(Date:3/28/2017)... Dr. Chris Yu , Chief ... Anpac Bio-Medical Science Company , announced this week ... and reporting over 40,000 cases worldwide of the ... liquid biopsy tests. Described as "game ... Anpac Bio,s CDA medical devices and technology effectively ...
(Date:3/28/2017)... , March 28, 2017 ... and unpredictable sector due to the scientifically intensive ... include medical, agricultural, environmental, and industrial. In today,s pre-market ... Portola Pharmaceuticals Inc. (NASDAQ: PTLA), OvaScience Inc. (NASDAQ: ... Therapeutix Inc. (NASDAQ: OCUL ). Learn ...
Breaking Biology Technology:
Cached News: