HOME >> BIOLOGY >> NEWS
Handicapping tuberculosis may be the way to a better vaccine

Howard Hughes Medical Institute investigator William R. Jacobs and colleagues have produced a genetically altered strain of tuberculosis (TB) that elicits a stronger immune response than the current vaccine, bacillus Calmette-Gurin (BCG). The new vaccine improves survival of infected animals and may help put scientists on track to replace BCG, which has been used for nearly a century although it is largely ineffective.

Despite widespread vaccination programs, the World Health Organization estimates that approximately 2 billion people worldwide are infected with TB, with over 95 percent of infections occurring in developing countries. Most TB is latent, but can become active when the immune system is weak, such as during HIV infection, and more than 1.6 million die each year from this disease. In addition, resistance to current treatments is becoming increasingly common, making an effective vaccine all the more crucial.

Were very excited because this is the first vaccine strain weve ever seen that is significantly better than BCG, said Jacobs.

Jacobs worked in collaboration with Steven Porcelli at the Albert Einstein College of Medicine. The team will publish its findings in the August, 2007, issue of the Journal of Clinical Investigation.

The immune system has a very difficult time detecting and combating Mycobacterium tuberculosis, the bacteria responsible for tuberculosis. By creating a strain of TB that behaves differently, Jacobs believes he can build a vaccine that prepares the body to recognize TB when infected.

If a cell becomes aware that a pathogen has invaded, it can prevent the infection from spreading to other cells by committing cell suicidea process known as apoptosis, where the cell shuts down and is shredded into little pieces.

Immune system cells further chop up these cellular bits and present them to white blood cells called T lymphocytes. Each T lymphocyte specifically recognizes a different sma
'"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
1-Aug-2007


Page: 1 2 3

Related biology news :

1. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
2. Developing a more effective vaccine for tuberculosis
3. Why is long-term therapy required to cure tuberculosis?
4. UA researchers identify new adherence factor, Pili, produced by tuberculosis
5. Shorter tuberculosis therapies could lead to substantial reductions in cases and deaths
6. Pitt phage hunter takes on tuberculosis
7. Cost-effectiveness of treating multidrug-resistant tuberculosis
8. New potential drug target in tuberculosis
9. National Institutes of Health funds $13.7 million for Texas tuberculosis study
10. Einstein researchers find potential new drugs for tuberculosis
11. Studies suggest new targets for tuberculosis treatments

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... , April 5, 2017  The Allen Institute for ... Cell Explorer: a one-of-a-kind portal and dynamic digital window ... imaging data, the first application of deep learning to ... stem cell lines and a growing suite of powerful ... for these and future publicly available resources created and ...
(Date:3/30/2017)... March 30, 2017  On April 6-7, 2017, Sequencing.com ... Genome hackathon at Microsoft,s headquarters in ... will focus on developing health and wellness apps that ... Hack the Genome is the first hackathon for ... world,s largest companies in the genomics, tech and health ...
(Date:3/27/2017)... 27, 2017  Catholic Health Services (CHS) has ... Society (HIMSS) Analytics for achieving Stage 6 on ... . In addition, CHS previously earned a place ... an electronic medical record (EMR). "HIMSS ... of EMR usage in an outpatient setting.  This ...
Breaking Biology News(10 mins):
(Date:6/27/2017)... ... 2017 , ... Indiana-based Xylogenics announced today the release of ... The efficiencies created by the newest strain design will have an immediate ... wherein individual production plants are planning to invest upwards of $350 million annually ...
(Date:6/26/2017)... (PRWEB) , ... June 26, 2017 , ... ... that Melissa Kirkegaard, the former Associate Director of Product Development R&D at Allergan ... and pharmaceutical products at both start-up and established biopharma companies, has joined the ...
(Date:6/26/2017)... ... 26, 2017 , ... The Workgroup for Electronic Data Interchange (WEDI) , ... in healthcare information exchange and a statutory advisor to the U.S. Department of Health ... Office of the National Coordinator for Health Information Technology, will deliver the keynote at ...
(Date:6/23/2017)... ... June 23, 2017 , ... Biova, LLC., the leader in water ... Board of Directors. Dr. Henig will bring a wealth of scientific experience in the ... the Chief Technical and Scientific Officer of four major global companies in the last ...
Breaking Biology Technology:
Cached News: