Have I been here before?

"Have I been here before"? In today's fast-moving world of look-alike hotel rooms and comparable corridors, it can take a bit of thinking to answer this simple question. University of Bristol neuroscientists working with colleagues at the Massachusetts Institute of Technology (MIT) report in the June 7 early online edition of Science that they have identified a neuronal mechanism that our brains may use to rapidly distinguish similar, yet distinct places.

The work could lead to treatments for memory-related disorders, as well as for the confusion and disorientation that plague elderly individuals who have trouble distinguishing between separate but similar places and experiences.

Forming memories of places and contexts in which episodes occur engages a part of the brain called the hippocampus. The laboratory of Nobel Laureate, Susumu Tonegawa, Picower Professor of Biology and Neuroscience at MIT, has been exploring how each of the three hippocampal subregions-the dentate gyrus, CA1 and CA3-contribute uniquely to different aspects of learning and memory. In the current study, co-authors Matthew Jones, Research Councils UK (RCUK) Academic Fellow in the Department of Physiology at the University of Bristol and Dr Thomas McHugh, a Picower Institute research scientist, have revealed that the learning in the dentate gyrus is crucial in rapidly recognizing and amplifying the small differences that make each place unique.

Dr Jones, commenting on the paper, said: "We constantly make split-second decisions about how best to behave at a given place and time. To achieve this, our nervous system must employ highly efficient ways of rapidly recognising and learning important changes in our environment.

"This paper demonstrates that a particular protein signalling molecule (the NMDA receptor) in a particular network of brain neurons (the dentate granule cells of the hippocampus) is essential for these rapid discrimination processe

Contact: Joanne Fryer
University of Bristol

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