HOME >> BIOLOGY >> NEWS
Heart repair gets new muscle

Some organs in the human body deal with injury better than others. A flesh wound or muscle tear might hurt, but, assuming you are otherwise healthy, both will heal. The prognosis for a heart attack, on the other hand, is not so clear-cut.

It has long been thought that cardiac cells (cardiomyocytes) lack the capacity for self-renewal and repair, impeding the chances of a full recovery from a heart attack. However, recent evidence suggests that the heart might harbor stem cells after all and that such cells can be transformed into cardiomyocytes.

In a new study published in the premier open-access online journal PLoS Biology, Neal Epstein and colleagues report that a special group of cells (called skeletal precursors of cardiomyocytes, or Spoc cells) isolated from the skeletal muscle of adult mice can turn into beating cardiomyocytes in a test tube within days of isolation. When these cells are injected into mice with heart damage, they migrate to the damaged tissue and differentiate into cardiac muscle cells.

Epstein and colleagues argue that Spoc cells are more likely to be precursors to cardiomyocytes than to be some other type of skeletal muscle stem cell. This is based on an absence of protein markers for skeletal muscle cells in Spoc cells, as well as the fact that Spoc-derived cells display spontaneous rhythmic beating and express cardiac markers, whether they are grown in a test tube or have migrated to injured hearts in study mice.

The authors can't say why skeletal muscle would harbor cardiac stem cells, but for now, the Spoc cells provide a valuable tool for studying heart cell differentiation. And with time, they might prove an important resource for developing cell-based therapies for heart disease.


'"/>

Contact: Paul Ocampo
pocampo@plos.org
415-624-1224
Public Library of Science
14-Mar-2005


Page: 1

Related biology news :

1. Hearts of male and female rainbow trout are different
2. Heart failure: Intervention possibilities from imaging programmed cell loss
3. Heart intervention doesnt outweigh medicine in study
4. International Society for Heart and Lung Transplantation 27th Annual Meeting and Scientific Sessions
5. Heart rhythm genes possible factors in SIDS
6. Hearts or tails?
7. Heart smart: new drug improves blood flow
8. Heart has enough oxygen to survive hypothermia, CPR crucial
9. Defusing a time bomb: Heart attack risk-detection technology developed at UH
10. Heart failure wall stress drops 38% with moderate thyroid hormone therapy
11. New studies released at the Heart Rhythm Societys Annual Meeting

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2018)... ... , ... Today, the FSH Society , the world’s largest research-focused patient ... holding its 3rd annual Walk & Roll to Cure FSHD in Castle ... for public awareness and is raising funds to support the Society’s work. , The ...
(Date:8/15/2018)... ... 2018 , ... Exalto Bearings UK , the manufacturer of high quality ... ISO quality management certification to BS EN ISO 9001:2015. This ISO standard is based ... company’s ability to offer products and services of consistent high quality. , Over the ...
(Date:8/14/2018)... ... 13, 2018 , ... Career fairs provide an ideal setting ... systems at once. However, healthcare professionals often have hectic schedules with little spare ... healthcare providers who wish to explore opportunities and learn about multiple employers from ...
Breaking Biology News(10 mins):
(Date:9/7/2018)... ... , ... Akadeum Life Sciences today announced it has appointed George Dunbar to ... of numerous biotech companies. , He most recently served as president and CEO ... Capital in St. Louis, MO. Prior to ISTO, he was a Venture Partner ...
(Date:8/29/2018)... ... 2018 , ... Cognition Corporation ®, a software company specializing in medical ... . , Ryan Ward, Director of Engineering at Zimmer Biomet, has been announced ... and manager with Zimmer Biomet for almost 15 years, Mr. Ward will focus his ...
(Date:8/26/2018)... ... August 23, 2018 , ... LabRoots , ... from around the world, will host the 4th Annual Microbiology and Immunology Virtual ... and disciplines, encompassing various research areas including medicine, agriculture, and space. , ...
(Date:8/21/2018)... ... 21, 2018 , ... The Connecticut Technology Council (CTC) and Marcum LLP today ... technology companies in Connecticut. This year’s group of top-ranked companies will be honored at ... Connecticut Convention Center in Hartford. A complete list of the Marcum Tech Top 40 ...
Breaking Biology Technology:
Cached News: