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Heart responds to fasting by remodeling vital energy-producing components

st and are subject to a vast array of hormonal influences during the sleep-wake cycle," Gross says. "The alterations in heart muscle energy utilization during fasting may setup a deleterious situation in the hearts of ischemic heart patients."

The research team uncovered the fluctuations in cellular lipids through an innovative new technology they developed called "shotgun lipidomics." As the name suggests, in comparison to other techniques shotgun lipidomics has the speed and coverage of a shotgun blast: From a simple one-step extraction of lipids in tissues, the team can obtain in minutes highly accurate measurements of the various cellular lipids, which previously have been notoriously fragile, time-consuming to analyze and hard to quantify.

"Through the efforts of people in our division like Xianlin Han, who has worked hard to perfect the technology, we have been able to open up fresh avenues of investigation using shotgun lipidomics," Gross says.


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Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
19-Nov-2004


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