HOME >> BIOLOGY >> NEWS
Hebrew U. / Johns Hopkins study provides clues to dealing with human disease

Jerusalem A step towards understanding cell mutations that cause a variety of human diseases, particularly in children -- including that which brings about premature aging and early death -- has been taken by researchers at the Hebrew University of Jerusalem Silberman Institute of Life Sciences and the John Hopkins University School of Medicine.

The scientists have focused their research on a study of induced mutations in the nuclear envelope of cells from the tiny C. elegans worm. Their aim is to thus provide clues towards a better understanding of mutations in proteins of the envelope of the cell nucleus in humans.

Such mutations, particularly in lamin (nuclear envelope) proteins A and C, cause many different diseases, including Hutchison Gilford progeria syndrome. Children with this disease develop premature aging and die usually before the age of 13. Other diseases brought about by these mutations include a form of muscular dystrophy, cardiomyopathy (a weakening of the heart muscle), and various other forms of irregular or retarded growth in childhood.

A report on the lamin research project was published in a recent issue of the Proceedings of the National Academy of Sciences in the U.S. The project was carried out primarily by Ayelet Margalit, a doctoral student in genetics at the Hebrew University, working under the supervision of Prof. Yosef Gruenbaum, and in cooperation with Prof. Katherine L. Wilson and Dr. Miriam Segura-Totten of Johns Hopkins University.

Experimenting with removal of the worm's lamin protein or its interacting protein partners emerin, MAN1 or BAF, the researchers have described "down-the-line" consequences, including the disruption of various proteins necessary for normal cell reproduction. Even though the C. elegans worm has only one lamin protein and few proteins that interact with it, the processes that occur there are similar to what happens in humans and provide clues to the laminopathic diseases a
'"/>

Contact: Jerry Barach
jerryb@savion.huji.ac.il
972-2-588-2904
The Hebrew University of Jerusalem
30-Aug-2005


Page: 1 2

Related biology news :

1. A first -- Hebrew University scientist observes brain cell development in real time
2. Hebrew University in leading spots in world university rankings
3. LEGO-Like building blocks to halt cell growth wins Hebrew University prize
4. Hebrew University researchers uncover eight previously unknown species
5. Are dancers genetically different than the rest of us? Yes, says Hebrew University researcher
6. Breakthrough: Structure of membrane protein described by Hebrew University, German researchers
7. Mutant protein developed by Hebrew University scientists
8. Hebrew University professor wins Wolf Prize in Medicine for work in cancer research
9. European Union cites excellence of Hebrew University neural computation center
10. Study by US, Hebrew University scientists sheds light on how bacteria persist despite antibiotics
11. Johns Hopkins Bloomberg School of Public Health, Geisinger launch new environmental research group

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2020)... ... 27, 2020 , ... Today bioinformatics leader hc1® ... combines lab testing insights and hc1’s exclusive Local Risk Index in a unified ... of employees returning to the workplace. , “Some of the best ways to ...
(Date:5/28/2020)... ... May 28, 2020 , ... Actuate Therapeutics, Inc. (Actuate), ... Phase 1/2 study (NCT03678883, EudraCT #: 2018-003739-32) will be presented at this year’s ... on May 29th, 2020. Dr. Benedito Carneiro, Brown University’s principal investigator on the ...
(Date:5/25/2020)... Kingdom (PRWEB) , ... May 22, 2020 , ... Oxford ... for the detection of SARS-CoV-2, the virus that causes COVID-19. , The ... on-demand analysis of smaller sample numbers, to very large numbers of samples. Hardware ...
Breaking Biology News(10 mins):
(Date:5/14/2020)... ... May 13, 2020 , ... Early stages ... providing little or no information on the drug’s mechanism of action (MOA). Gene ... compounds by measuring the activity of molecular pathways. This information can complement phenotypic ...
(Date:5/5/2020)... ... May 05, 2020 , ... ... the launch of its iGlucose® LTE Cat-M Cellular Connected Diabetes Blood ... Cat-M1 technology, the industry’s newest and broadest cellular connectivity available, to provide patients ...
(Date:4/22/2020)... ... April 20, 2020 , ... ... MA, announced today that Omixon’s founder and chairman Dr. Attila Berces returns as ... product Holotype HLA since 2014 before stepping into the CEO role in 2017. ...
(Date:4/7/2020)... (PRWEB) , ... April 06, 2020 , ... Gateway ... future children, reached 200,000 SneakPeek Early Gender DNA Tests sold in March, ... was launched as an ecommerce product, where a mom could order her kit ...
Breaking Biology Technology:
Cached News: