HOME >> BIOLOGY >> NEWS
Heparin prepared synthetically could replace animal-derived drug

Researchers at Rensselaer Polytechnic Institute and University of North Carolina at Chapel Hill have discovered an alternative way to produce heparin, a drug commonly used to stop or prevent blood from clotting. The findings could enable the current supply of the drug now extracted from animal tissue to be replaced or supplemented by the synthetic version. The new process also can be applied as a tool for drug discovery, according to the researchers.

Heparin is a complex carbohydrate used to stop or prevent blood from clotting during medical procedures and treatments such as kidney dialysis, heart bypass surgery, stent implantation, indwelling catheters, knee and hip replacements, and deep vein thrombosis. The annual worldwide sales of heparin are estimated at $3 billion.

"We have synthetically prepared heparin in quantities large enough for use in human medical treatments by engineering recently discovered heparin biosynthetic enzymes," says Robert Linhardt, the Ann and John H. Broadbent Jr. '59 Senior Constellation Professor of Biocatalysis and Metabolic Engineering at Rensselaer Polytechnic Institute. "These discoveries will enable us to effectively replace a variable raw material heparin derived from processed animal organs with a synthetic material synthetic heparin and have the same therapeutic result."

Research in Linhardt's group at the Center for Biotechnology and Interdisciplinary Studies at Rensselaer focuses on complex carbohydrates such as heparin. After determining the structure of these molecules, researchers study their biological activities to establish a structure-activity relationship that may reveal lead compounds for new drug development.

Researchers at MIT first prepared a synthetic heparin, but, in amounts of less than 1 microgram, it was insufficient to treat humans, says Linhardt. One human dose of heparin is approximately 100 milligrams.

Rensselaer and UNC-Chapel Hill researchers successfully s
'"/>

Contact: Tiffany Lohwater
lohwat@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
6-Feb-2006


Page: 1 2

Related biology news :

1. Rural America more prepared for disaster -- also more vulnerable
2. Are we prepared?
3. Draft environmental impact statement prepared for USAMRIID facilities at Fort Detrick
4. Biodesign Institute participates in first-of-its-kind coyote disaster preparedness drill
5. A 2002 disease threat offers lessons for avian flu preparedness
6. Newly created cancer stem cells could aid breast cancer research
7. New system of wastewater treatment could reduce the size of treatment plants by half
8. Discovery of new protein could provide new understanding of male fertility
9. Einstein researchers prototype vaccine could provide improved protection against tuberculosis
10. How a pain in the neck could be bad for your blood pressure
11. Synchrotron could help save the Tassie devil

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/26/2020)... ... August 25, 2020 , ... ... in partnership with Essex Bio-Technology, a bio-pharmaceutical company specializing in Ophthalmology and ... study of SkQ1 ophthalmic solution in patients with moderate to severe Dry ...
(Date:8/23/2020)... WOODLANDS, Texas (PRWEB) , ... August 21, 2020 ... ... from Rigaku Corporation has been published and is now available on ... single crystal X-ray diffraction—serves the X-ray analysis community, presenting current news and crystallographic ...
(Date:8/21/2020)... ... August 19, 2020 , ... The 19th Annual Bio-IT ... data science, informatics and IT leaders goes VIRTUAL and announces its updated event ... change, Bio-IT takes the leadership role of keeping our life science community connected ...
Breaking Biology News(10 mins):
(Date:8/12/2020)... BINGHAM FARMS, Mich. (PRWEB) , ... August 12, ... ... International Consulting Group, Inc. (EMMA International), a global leader in FDA compliance ... ranking of the nation’s fastest-growing private companies. The list represents a unique look ...
(Date:7/31/2020)... , ... July 29, 2020 , ... ... announced the launch of its new tagline, “BUILDING FOR LIFE.” The adoption of ... and around the globe, requiring fast track capacity to provide patients with urgently ...
(Date:7/31/2020)... ... July 29, 2020 , ... The ... centers in 16 countries, has reached its 20th anniversary of worldwide use. Introduced ... use at top universities including University of Pennsylvania, University of Michigan, University of ...
(Date:7/18/2020)... ... July 16, 2020 , ... ... in the early detection and prevention of high-burden diseases, and Centric Consulting, a ... and healthcare organizations to utilize existing data in order to identify and prioritize ...
Breaking Biology Technology:
Cached News: