HOME >> BIOLOGY >> NEWS
Herceptin plus chemotherapy significantly increases disease-free survival in breast cancer

Combining the molecularly targeted therapy Herceptin with chemotherapy in women with early stage breast cancer significantly improves disease-free survival for patients with a specific genetic mutation that results in very aggressive disease, a top UCLA researcher reported Thursday.

Dr. Dennis Slamon, whose laboratory and clinical research lead to the development of Herceptin, reported results of the Phase III study of more than 3,200 women Thursday at the 29th annual San Antonio Breast Cancer Symposium.

The three-armed study compared the standard therapy of Adriamycin and Carboplatin followed by Taxotere (ACT), an experimental regimen of Adriamycin and Carboplatin followed by Taxotere and one year of Herceptin (ACTH), and an experimental regimen of Taxotere and Carboplatin with one year of Herceptin (TCH).

The study tested Herceptin with and without Adriamycin, an anthracycline commonly used to treat breast cancer but one that, when paired with Herceptin, can cause permanent heart damage. Researchers wanted to determine whether they could provide a therapy as effective as ACTH without the resulting cardiac problems. The study, Slamon said, showed that the women who did not receive Adriamycin did just as well as those who did, and they experienced a five-fold decrease in significant heart toxicities compared to those who got Adriamycin. Also, some women in the ACTH arm developed leukemias, while none of the women on the non-Adriamycin arm did, Slamon said.

"This study demonstrates unequivocally that the best treatment for early stage HER-2 positive breast cancer is obtained with a non-anthracycline regimen, TCH, that avoids the significant cardiac damage found when Adriamycin is used with Herceptin," said Slamon, director of clinical/translational research at UCLAs Jonsson Cancer Center. "This trial should impact the way early stage breast cancer is treated, with TCH being considered the preferred option."

H
'"/>

Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
14-Dec-2006


Page: 1 2

Related biology news :

1. Gene profiling predicts resistance to breast cancer drug Herceptin
2. Herceptin plus chemotherapy improves disease-free survival in early breast cancer
3. Nanoparticles carry chemotherapy drug deeper into solid tumors
4. A faster way to recover from chemotherapy and marrow transplant
5. PET accurately identifies esophageal cancer patients positive responses to chemotherapy
6. Combining NSAIDs with chemotherapy, radiation may improve cancer treatment
7. FDG-PET imaging clearly predicts lung cancer patients response to chemotherapy
8. Gene analysis might explain ethnic differences in sensitivity to chemotherapy in lung cancer
9. Enhancing chemotherapys efficacy: New agent has synergistic effect with standard drugs
10. Massive gene screening points way to more effective chemotherapy
11. Researchers find the mechanism by which cells resist chemotherapy

Post Your Comments:
(Date:7/22/2014)... genus of planthopper known as Conosimus, which now includes ... in the southern part of the Iberian Peninsula in ... appears in the open-access Journal of Insect Science ... Conosimus baenai , has been named after Manuel ... taxonomy of Iberian Hemiptera. , Conosimus baenai ...
(Date:7/21/2014)... 2014 (Toronto) As part of a multinational, collaborative ... Health (CAMH) have helped identify over 100 locations in ... schizophrenia, in what is the largest genomic study published ... online in Nature , point to biological mechanisms ... to new approaches to treating the disorder, which has ...
(Date:7/21/2014)... of Middle East Respiratory Syndrome coronavirus (MERS-CoV) in the ... the virus. The work, published this week in ... Society for Microbiology, indicates that further studies are needed ... the air. , MERS, a serious viral respiratory illness ... people as of June 11, according to the World ...
Breaking Biology News(10 mins):International team sheds new light on biology underlying schizophrenia 2International team sheds new light on biology underlying schizophrenia 3Middle East Respiratory Syndrome coronavirus detected in the air of a Saudi Arabian camel barn 2
(Date:7/21/2014)... July 21, 2014 Lawrence ... Investment Board (WIB) and Las Positas College (LPC) ... technical education and hands-on training for veterans, officials ... Program at Las Positas is designed to ... for engineering technician careers, and establishes a pipeline ...
(Date:7/21/2014)... (July 21, 2014) The yield so far is ... developed a low-energy, solution-based mineral substitution process to make ... use in electronics and alternative energy devices. , A ... of the July 21 issue of the journal ... research in the inorganic and nuclear chemistry fields. The ...
(Date:7/20/2014)... the process releases radioactive krypton and xenon gases. Naturally ... gas radon. A new porous material called CC3 effectively ... Nature Materials shows how: by breathing enough ... , The CC3 material could be helpful in removing ... air in buildings and also in recycling useful elements ...
(Date:7/18/2014)... LANSING, Mich. , July 18, 2014  Neogen ... Stephen Snyder , Neogen,s chief operating officer and ... said he will work as a consultant going forward ... Snyder has been in this position since ... be fulfilled by James Herbert , who has ...
Breaking Biology Technology:Engineering Program Established for Veterans 2Engineering Program Established for Veterans 3Oregon chemists eye improved thin films with metal substitution 2A noble gas cage 2A noble gas cage 3
Cached News: