HOME >> BIOLOGY >> NEWS
High blood pressure, low energy -- a recipe for heart failure

Aug. 10, 2007 -- Many people with long-standing high blood pressure develop heart failure. But some don't. Daniel P. Kelly, M.D., and colleagues at Washington University School of Medicine in St. Louis and other institutions are trying to figure out what could explain that difference.

Their latest research reveals that impaired energy production in heart muscle may underlie heart failure in some hypertensive patients. The researchers assert that a molecular factor involved in maintaining the heart's energy supply could become a key to new approaches to prevent or treat heart failure.

The molecular factor, a protein called estrogen-related receptor alpha (ERR alpha), helps the heart keep up with energy-draining conditions like high blood pressure, which makes the heart work harder to pump blood. In the July issue of Cell Metabolism, Kelly and his colleagues report that mice born without any ERR alpha developed symptoms of heart failure when their hearts were forced to pump against high pressure. The hearts of normal mice took that pressure overload in stride and stayed healthy. Those contrasting outcomes suggest that heart health greatly depends on ERR alpha.

"The stress of a cardiac pressure overload asks heart muscle to manufacture more high energy compounds, and without ERR alpha, they can't do it," explains Kelly, the Tobias and Hortense Lewin Professor and Chief of the Cardiovascular Division. "You could say that in high blood pressure conditions, the heart fails because it becomes energy starved. And if you could feed the heart by using a drug that enhances ERR, for example you might enable the heart to better keep pace with its energy requirements."

Although preventions and treatments are now available for heart failure due to high blood pressure, almost all of those drugs act outside the heart by dilating blood vessels throughout the body to reduce resistance. In the future, doctors might look for diminished energy capacity in
'"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
10-Aug-2007


Page: 1 2

Related biology news :

1. Brain blood flow gives clues to treating depression
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Research aims to identify markers for menopausal women at risk for deadly blood clot
5. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
6. A low expression of MX2 gene exists in the white blood cells of narcoleptics
7. How a pain in the neck could be bad for your blood pressure
8. Penn researchers discover pathway that eliminates genetic defects in red blood cells
9. U-M team identifies gene that regulates blood-forming fetal stem cells
10. MicroRNA works with Ago2 protein to regulate blood cell development
11. 1 in 4 NYC adults has elevated blood mercury levels

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/1/2018)... ... 01, 2018 , ... RURO, Inc., a company known for ... is the software framework that all of RURO’s products are built from, and ... and the future of RURO’s laboratory software portfolio. , To accommodate the needs ...
(Date:7/31/2018)... DIEGO (PRWEB) , ... July 31, 2018 , ... ACEA ... analysis. The company has just introduced the xCELLigence RTCA S16, which the ... and monitored via an external computer, the S16can be placed in any standard CO2 ...
(Date:7/30/2018)... ... July 30, 2018 , ... TC Slade, ... impact of biofield energy healing treated Vitamin D3 on the strength and health ...     Over 260% increase in ALP, a bone-specific enzyme ,     Over 240% ...
Breaking Biology News(10 mins):
(Date:7/31/2018)... ... July 31, 2018 , ... Leading regenerative veterinary ... for extracting and using adipose tissue-derived stem cells to treat or prevent inflammation ... this patent covers Canada specifically, VetStem has been issued similar patents that cover ...
(Date:7/25/2018)... ... July 25, 2018 , ... Eileen ... impact of a biofield energy treated nutraceutical to improve skin health parameters including ... for skin health and reported the following results:,     More ...
(Date:7/25/2018)... ... July 25, 2018 , ... John McDonald, ... the board of the Indiana India Business Council (IIBC), an advocacy group to ... the current board of directors, McDonald joins an impressive roster of local and ...
(Date:7/22/2018)... , ... July 19, 2018 , ... ... driven channel professional has joined their team. With more than ten years of ... Adam will deliver his expertise as CallTower’s Channel Director for the Southwest and ...
Breaking Biology Technology:
Cached News: