HOME >> BIOLOGY >> NEWS
High blood pressure, low energy -- a recipe for heart failure

Aug. 10, 2007 -- Many people with long-standing high blood pressure develop heart failure. But some don't. Daniel P. Kelly, M.D., and colleagues at Washington University School of Medicine in St. Louis and other institutions are trying to figure out what could explain that difference.

Their latest research reveals that impaired energy production in heart muscle may underlie heart failure in some hypertensive patients. The researchers assert that a molecular factor involved in maintaining the heart's energy supply could become a key to new approaches to prevent or treat heart failure.

The molecular factor, a protein called estrogen-related receptor alpha (ERR alpha), helps the heart keep up with energy-draining conditions like high blood pressure, which makes the heart work harder to pump blood. In the July issue of Cell Metabolism, Kelly and his colleagues report that mice born without any ERR alpha developed symptoms of heart failure when their hearts were forced to pump against high pressure. The hearts of normal mice took that pressure overload in stride and stayed healthy. Those contrasting outcomes suggest that heart health greatly depends on ERR alpha.

"The stress of a cardiac pressure overload asks heart muscle to manufacture more high energy compounds, and without ERR alpha, they can't do it," explains Kelly, the Tobias and Hortense Lewin Professor and Chief of the Cardiovascular Division. "You could say that in high blood pressure conditions, the heart fails because it becomes energy starved. And if you could feed the heart by using a drug that enhances ERR, for example you might enable the heart to better keep pace with its energy requirements."

Although preventions and treatments are now available for heart failure due to high blood pressure, almost all of those drugs act outside the heart by dilating blood vessels throughout the body to reduce resistance. In the future, doctors might look for diminished energy capacity in
'"/>

Contact: Gwen Ericson
ericsong@wustl.edu
314-286-0141
Washington University School of Medicine
10-Aug-2007


Page: 1 2

Related biology news :

1. Brain blood flow gives clues to treating depression
2. Study finds gender differences in renal and other genes contributing to blood pressure
3. Study suggests estrogen deficiency can lead to obesity-induced high blood pressure after menopause
4. Research aims to identify markers for menopausal women at risk for deadly blood clot
5. Teamwork between 2 key proteins necessary for normal development and regulation of red blood cells
6. A low expression of MX2 gene exists in the white blood cells of narcoleptics
7. How a pain in the neck could be bad for your blood pressure
8. Penn researchers discover pathway that eliminates genetic defects in red blood cells
9. U-M team identifies gene that regulates blood-forming fetal stem cells
10. MicroRNA works with Ago2 protein to regulate blood cell development
11. 1 in 4 NYC adults has elevated blood mercury levels

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/5/2017)... Allen Institute for Cell Science today announces the launch ... dynamic digital window into the human cell. The website ... deep learning to create predictive models of cell organization, ... suite of powerful tools. The Allen Cell Explorer will ... resources created and shared by the Allen Institute for ...
(Date:3/30/2017)... 30, 2017  On April 6-7, 2017, Sequencing.com will ... hackathon at Microsoft,s headquarters in ... focus on developing health and wellness apps that provide ... the Genome is the first hackathon for personal ... largest companies in the genomics, tech and health industries ...
(Date:3/27/2017)... N.Y. , March 27, 2017  Catholic ... Information and Management Systems Society (HIMSS) Analytics for ... EMR Adoption Model sm . In addition, CHS ... of U.S. hospitals using an electronic medical record ... for its high level of EMR usage in ...
Breaking Biology News(10 mins):
(Date:7/17/2017)... ... 17, 2017 , ... Panitch Schwarze Belisario & Nadel ... BiG (Biomedical Innovation Group) annual meeting in China. , This year’s meeting, held ... T-cell) therapy, a rapidly developing highly personalized anti-cancer technology that involves removing some ...
(Date:7/16/2017)... ... July 16, 2017 , ... ... analytical instruments announced the launch of its new line of Rocking and Waving ... and waving shaker models (both analog and digital) for laboratory applications in a ...
(Date:7/14/2017)... , ... July 14, 2017 , ... ... EMS company . Sonic Manufacturing Technologies has installed a solar system on its ... a three-year period,” the President of Sonic, Kenneth Raab stated. The company’s proud ...
(Date:7/14/2017)... Liege, Belgium/ Denville, USA/ Martinsried, Germany (PRWEB) , ... ... ... today announced a newly developed standardized solution for sample preparation of proteins to ... Kit) and the Diagenode Bioruptor® sonication system. , The PreOmics iST Kit ...
Breaking Biology Technology:
Cached News: