HOME >> BIOLOGY >> NEWS
High resolution 'snapshots' detail dynamics of a cocaine antibody

Cocaine-binding antibodies have shown some promise in their ability to neutralize cocaine toxicity, but their binding ability is severely impaired by high concentrations of the drug. A catalytic monoclonal antibody such as 7A1, on the other hand, has the ability to regenerate after each new dose of the drug, making it far more effective than others in metabolizing cocaine.

The study, which will be published in the February issue (Volume 14 Issue 2) of the journal Structure, was led by Ian A. Wilson, D.Phil., of Scripps Research Department of Molecular Biology and The Skaggs Institute for Chemical Biology, and Kim D. Janda, Ph.D., of Scripps Research Departments of Chemistry and Immunology and The Skaggs Institute for Chemical Biology.

Despite intensive research, cocaine abuse continues to be a major public health problem, so far eluding efforts at developing an effective therapeutic agent to counter the craving, addiction, and overdose of the drug. To date, no treatment has been approved by the Food and Drug Administration (FDA).

Commenting on the new findings, Xueyong Zhu, Ph.D., the primary author of the study and a staff scientist in the Wilson laboratory said, "Development of effective therapies for cocaine abuse has been a long-standing goal, and a number of medications under study do show some promise. Immunopharmacotherapy has been proposed as a way to neutralize the drug outside the central nervous system- basically soaking up the drug before it has a chance to cross the blood brain barrier-as a potentially effective new approach to treat cocaine abuse."

Using a monoclonal antibody endowed not only with high binding ability, but also with sufficient catalytic activity to metabolize cocaine, would have potentially enhanced therapeutic effects, Zhu said. This antibody could intercept cocaine in the blood stream before it reaches the central nervous system-stopping the drug cold. Because cocaine has a half life of approximately 3
'"/>

Contact: Keith McKeown
kmckeown@scripps.edu
858-784-8134
Scripps Research Institute
8-Feb-2006


Page: 1 2 3

Related biology news :

1. MicroRNA conflict resolution
2. New Years resolution No. 1: Prevent cancer, use olive oil.
3. With record resolution and sensitivity, tool images how life organizes in a cell membrane
4. New type of optical microscopy attains near-molecular resolution
5. Recombination protein dynamics observed with single monomer resolution
6. Atomic-resolution structure of a ribozyme yields insights into RNA catalysis and the origins of life
7. New law for resolution allows unprecedented sharpness in fluorescence microscopy
8. Scientists take snapshots of enzyme action
9. Census of Marine Life historians detail collapse of bluefin tuna population off northern Europe
10. UC experts detail new standard for cleaner transportation fuels
11. New Naval S&T Strategy to be detailed at partnership conference

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... (PRWEB) , ... June 23, 2020 , ... ... supporting sustainable healthcare, and Renovagen Ltd, a UK supplier and manufacturer of innovative ... to support testing operations in the fight against the COVID-19 pandemic in Zambia. ...
(Date:6/23/2020)... ... June 23, 2020 , ... Rigaku Corporation ... next event in a series of TOPIQ webinars, which will cover the Transferable ... was developed in response to social distancing measures that resulted in postponements and ...
(Date:6/19/2020)... ... June 16, 2020 , ... The director of stem cell ... if the stem cell medicine and pharmaceutical industries have easier access to stem cell ... starting July 5 of this year, Independence Day weekend in the U.S., Asymmetrex is ...
Breaking Biology News(10 mins):
(Date:8/3/2020)... ... 03, 2020 , ... Introducing Ardent Animal Health – MediVet Biologics rebrands company ... Known as MediVet Biologics since its formation in 2016, the company is relaunching ... Health will build on its base of innovative therapies for osteoarthritis and cancer. ...
(Date:7/31/2020)... ... July 29, 2020 , ... Editas ... global provider of advanced delivery technologies, development, and manufacturing solutions for drugs, biologics, ... entered into a strategic partnership whereby Catalent will provide support for the development, ...
(Date:7/18/2020)... ... July 16, 2020 , ... After research model surgery and catheter implantation, ... surgery is only the beginning of a successful study, while protecting and accessing the ... Gien, Global Head of Surgery from Envigo in a live webinar ...
(Date:7/10/2020)... BALTIMORE (PRWEB) , ... July ... ... Baltimore biotechnology company, announced today that Massachusetts Institute of Technology (MIT) has ... This broader license allows PathSensors to move into the point-of-care diagnostic market, ...
Breaking Biology Technology:
Cached News: