HOME >> BIOLOGY >> NEWS
Histamine, anxiety and alcoholism

In the brain, histamine regulates a wide variety of physiological processes, including water and food intake, sleep-wake cycles, endocrine homeostasis, locomotion, and memory and learning. In a new study, researchers have found that decreased levels of brain histamine, which are associated with a functional polymorphism of histamine N-methyltransferase (HNMT) called Thr105 allele, may also result in higher levels of anxiety which may, in turn, confer vulnerability to alcoholism. Results are published in the March issue of Alcoholism: Clinical & Experimental Research.

"We were interested in examining the role of the functional Thr105Ile variant of HNMT because this is the enzyme which accounts for the degradation of histamine in mammalian brain," said Gabor Oroszi, a researcher at the National Institute on Alcohol Abuse and Alcoholism and first author of the study. "Since clinical experience with antihistamine drugs has indicated that blockade of histamine 1 receptors results in sedation, anxiolysis and sleepiness which are very strong in many patients we hypothesized that altered function of the sole histamine metabolizing enzyme in the brain might alter anxiety, a state frequently encountered by alcoholics."

Oroszi and his colleagues examined two distinct populations of alcoholics 218 Finnish Caucasians (206 males, 12 females) and 186 Plains American Indians (98 males, 88 females) for an association among the Thr105lle polymorphism, alcoholism, and "harm avoidance," a dimensional measure of anxious personality. Researchers also examined two groups of nonalcoholic "controls," 313 Finns (220 males, 93 females) and 140 Plains Indians (36 males, 104 females) for comparison's sake.

"We chose these two populations because they were well characterized in terms of both alcohol abuse and dependence, as well as harm avoidance," said Oroszi. "There was a sufficient number of alcoholics and nonalcoholic controls to allow us to compare
'"/>


14-Mar-2005


Page: 1 2 3

Related biology news :

1. New insights into the neural basis of anxiety
2. New insight about the source of anxiety in Rett syndrome
3. New findings may lead to treatment for anxiety in Rett Syndrome
4. Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety
5. Seasonal depression, anxiety affects hamsters, study finds
6. A genome wide search for genes underlying anxiety disorders turned up unexpected candidates
7. Oxytocin raises aggression, cuts anxiety during lactation; similar effects on virgin rats
8. Screening for genetic disorders: Need to avoid anxiety
9. Gene variant increases risk for alcoholism following childhood abuse
10. Spousal choices can influence the risk of developing alcoholism
11. A form of the alcohol dehydrogenase gene may protect Afro-Trinidadians from developing alcoholism

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/6/2019)... , ... February 04, 2019 , ... ... new Explorer™ story which provides insights to help individuals understand how the gut ... cardiovascular wellness. , After individuals eat foods that contain choline and L-carnitine, ...
(Date:2/2/2019)... ... January 31, 2019 , ... Aperio ... customizable clinical research services across multiple therapeutic areas, announced an Innovation Partner ... life science entrepreneurs in the Research Triangle region of North Carolina. ...
(Date:1/25/2019)... ... January 24, 2019 , ... GrowthZone, Inc., ... Survey. The report indicates membership growth in some sectors and decreasing membership among ... received responses from over 500 association professionals across North America. , “This ...
Breaking Biology News(10 mins):
(Date:1/15/2019)... ... 2019 , ... Personalized treatment plans may extend life expectancy for early-stage kidney ... study published in the journal Radiology. , Kidney, or renal, tumors are often ... procedure in which the tumor and part of the kidney are removed. However, some ...
(Date:1/11/2019)... ... ... Drawing on over 22 years of software development expertise, the live webinar ... the key lessons that have driven customer satisfaction with their eClinical suite. Explore the ... how to ensure that you continue to be able to take advantage of the ...
(Date:1/10/2019)... ... 2019 , ... VGI Medical was founded in 2007 based on an invention ... the market including VerteLoc, CerLoc, SiJoin and VerteLP. The VerteLoc and CerLoc systems are ... dual geometric design to limit motion of the affected spinal segment. Applying the principles ...
(Date:1/7/2019)... (PRWEB) , ... January 07, 2019 , ... ... 1 clinical trials of its Parkinson's Disease drug candidate, code-named "KM-819." KM-819 ... Parkinson's Disease. The trial took place in South Korea. , This Phase ...
Breaking Biology Technology:
Cached News: