HOME >> BIOLOGY >> NEWS
Histamine tied to changes in blood pressure during exercise-recovery period

Overactivation of two receptors for histamine, normally associated with common allergies and acid reflux, may explain why some people, including highly trained athletes, pass out soon after heightened physical activities, according to researchers at the University of Oregon.

A series of studies led researchers in incremental steps to the discovery that the use of two commonly used antihistamines (fexofenadine and ranitidine) prior to exercise dramatically lower or completely eliminate low blood pressure following exertion. The drugs worked by preventing post-exercise hyperemia, an increased flow of blood, in the skeletal muscle during the critical 90-minute recovery period after exercise. In all, the pre-exercise consumption of the two antihistamines reduced the blood flow that occurs during recovery by 80 percent.

The study, funded by the American Heart Association, was posted online ahead of regular publication in the Journal of Applied Physiology. While fainting after exercise, a condition called syncope, can indicate a serious heart disorder, most cases are linked to low blood pressure and low blood flow to the brain.

"There is reason to believe that histamine is the primary vasodilator contributing to post-exercise hypotension, but we cannot say for certain," cautioned principal investigator John R. Halliwill, a professor of human physiology. "Some people have problems regulating blood pressure during and after exercise. Trained athletes have had fainting bouts at the end of exercise. It may be that these result from a natural overactivation of these two receptors for histamine."

The histamine receptors involved are known as H1 and H2. Fexofenadine, which is the generic name for Allegra, works against H1, reducing the occurrence of such allergy symptoms as sneezing and runny nose. Ranitidine, or Zantac, acts against H2 in the treatment of acid reflux.

For the study, 28 sedentary and endurance-trained men and
'"/>

Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
10-Oct-2006


Page: 1 2

Related biology news :

1. Histamine, anxiety and alcoholism
2. Acute sleep deprivation leads to changes in nighttime urine production for men and women
3. Marine phytoplankton changes form to protect itself from different predators
4. ENCODE map changes view of the human genome landscape
5. Small-scale agricultural changes may help eradicate widespread disease
6. Nanotechnology requires immediate changes in EPA
7. K-State to collaborate on research to forecast ecological consequences of environmental changes
8. Scientists: As rainfall changes, tropical plants may acclimate
9. Fish growth changes enhanced by climate change
10. Common fungicide causes long-term changes in mating behavior
11. New report: Explosive growth changes salmon industry

Post Your Comments:
(Date:9/2/2015)... About hand geometry biometrics Security has ... telecommunication and hospitals as well as for individuals to ... keypads are used to prevent unauthorised access. Hand geometry ... of an individual, width of the fingers, and thickness ... and reflectors can be used for capturing the image. ...
(Date:9/2/2015)... , Sept. 2, 2015 Security ... concern for enterprises, banks, government organizations, telecommunications, hospitals, ... numeric keypads were previously being used to prevent ... of two-factor authentication, wherein individuals could gain access ... different components, such as hardware devices and numeric ...
(Date:9/2/2015)... 2015 Biometric technology ... a system which uses identical human characteristic such ... DNA and finger print. Increasing number of terror ... system which provides high level of security. Traditional ... tokens are vulnerable to attacks. Furthermore, Biometric technology ...
Breaking Biology News(10 mins):Global Hand Geometry Biometrics Market 2015-2019 2Global Hand Geometry Biometrics Market 2015-2019 3Global Biometrics Spending Market in the Government Sector 2015-2019 2Global Biometrics Spending Market in the Government Sector 2015-2019 3Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 2Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 3Biometrics Technology Market is Expected to Reach $13.8 Billion by 2015: Hexa Research Inc. 4
(Date:9/4/2015)... ... September 04, 2015 , ... Canadian astronomer David Levy — who discovered ... maintained for nearly 60 years to the Linda Hall Library . , ... Jupiter in 1994 — an episode that produced the first collision between two solar ...
(Date:9/4/2015)... , Sep. 04, 2015 ... announced the addition of the "Biopreservation Market ... Global Forecast to 2020" report to their ... expected to reach USD 3,731.03 Million by 2020 ... a CAGR of 11.65% between 2015 and 2020. ...
(Date:9/4/2015)... ... September 04, 2015 , ... BioBots ... BioBot 1, at the 2015 TERMIS World Congress in Boston. The launch comes ... engineering institutions around the world. The printer is revolutionary for its compact design, ...
(Date:9/4/2015)... San Francisco, CA (PRWEB) , ... September 04, ... ... in the delivery of product safety and pharmacovigilance services and software tools to ... software application, PRIMO Mobile by Allergan Japan. PRIMO Mobile is a mobile data ...
Breaking Biology Technology:Renowned Astronomer David Levy To Donate Night Sky Observation Logs to the Linda Hall Library 2Renowned Astronomer David Levy To Donate Night Sky Observation Logs to the Linda Hall Library 3Global Biopreservation Market 2015-2020 - Product, Biospecimen, Application and End User Analysis of the $3.73 Billion Industry 2Global Biopreservation Market 2015-2020 - Product, Biospecimen, Application and End User Analysis of the $3.73 Billion Industry 3BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 2BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 3BioBots to Debut Desktop 3D Bioprinter for Living Tissue at TERMIS Global Tissue Engineering Conference in Boston 4November Research Group’s PRIMO Mobile Goes Live at Allergan Japan 2
Cached News: