HOME >> BIOLOGY >> NEWS
Histamine tied to changes in blood pressure during exercise-recovery period

Overactivation of two receptors for histamine, normally associated with common allergies and acid reflux, may explain why some people, including highly trained athletes, pass out soon after heightened physical activities, according to researchers at the University of Oregon.

A series of studies led researchers in incremental steps to the discovery that the use of two commonly used antihistamines (fexofenadine and ranitidine) prior to exercise dramatically lower or completely eliminate low blood pressure following exertion. The drugs worked by preventing post-exercise hyperemia, an increased flow of blood, in the skeletal muscle during the critical 90-minute recovery period after exercise. In all, the pre-exercise consumption of the two antihistamines reduced the blood flow that occurs during recovery by 80 percent.

The study, funded by the American Heart Association, was posted online ahead of regular publication in the Journal of Applied Physiology. While fainting after exercise, a condition called syncope, can indicate a serious heart disorder, most cases are linked to low blood pressure and low blood flow to the brain.

"There is reason to believe that histamine is the primary vasodilator contributing to post-exercise hypotension, but we cannot say for certain," cautioned principal investigator John R. Halliwill, a professor of human physiology. "Some people have problems regulating blood pressure during and after exercise. Trained athletes have had fainting bouts at the end of exercise. It may be that these result from a natural overactivation of these two receptors for histamine."

The histamine receptors involved are known as H1 and H2. Fexofenadine, which is the generic name for Allegra, works against H1, reducing the occurrence of such allergy symptoms as sneezing and runny nose. Ranitidine, or Zantac, acts against H2 in the treatment of acid reflux.

For the study, 28 sedentary and endurance-trained men and
'"/>

Contact: Jim Barlow
jebarlow@uoregon.edu
541-346-3481
University of Oregon
10-Oct-2006


Page: 1 2

Related biology news :

1. Histamine, anxiety and alcoholism
2. Acute sleep deprivation leads to changes in nighttime urine production for men and women
3. Marine phytoplankton changes form to protect itself from different predators
4. ENCODE map changes view of the human genome landscape
5. Small-scale agricultural changes may help eradicate widespread disease
6. Nanotechnology requires immediate changes in EPA
7. K-State to collaborate on research to forecast ecological consequences of environmental changes
8. Scientists: As rainfall changes, tropical plants may acclimate
9. Fish growth changes enhanced by climate change
10. Common fungicide causes long-term changes in mating behavior
11. New report: Explosive growth changes salmon industry

Post Your Comments:
(Date:10/28/2014)... differences in moving activity in a novel environment ... angling, according to an experimental study completed at ... Game and Fisheries Research Institute. The study used ... and authentic angling trials to analyse if behaviours ... reared in traditional and enriched hatchery rearing environments. ...
(Date:10/28/2014)... and citrus fruits and juices are associated with a ... research from the University of East Anglia (UEA). ... foods containing flavonols and flavanones (both subclasses of dietary ... cancer, the fifth-leading cause of cancer death among women. ... of 171,940 women aged between 25 and 55 for ...
(Date:10/27/2014)... are an indigenous species of the West Antarctic Peninsula ... Earth. Since 1950, the average annual temperature in the ... and 6 degrees Celsius during winter. , As ... dry, polar system to a warmer, sub-polar system with ... a connection between local weather conditions and the weight ...
Breaking Biology News(10 mins):Fish 'personality' linked to vulnerability to angling 2Tea and citrus products could lower ovarian cancer risk, new UEA research finds 2University of Delaware study connects penguin chick weights to local weather conditions 2University of Delaware study connects penguin chick weights to local weather conditions 3
(Date:10/30/2014)... 2014 Spartan Bioscience announced today that ... System . It detects CYP2C19 genetic mutations in less ... The Spartan RX CYP2C19 System is the first near-patient ... in Canada. Due to the system’s ease of use, ... by healthcare professionals such as doctors, nurses, pharmacists, and ...
(Date:10/30/2014)... , Oct. 30, 2014 A new report, ... Partnership Practice, takes an in-depth look at ... that have resulted over two different time frames: 1993 ... a view of future opportunities for investment growth.  The ... report shows gains in innovation dollars as ...
(Date:10/27/2014)... October 27, 2014 The new ... Type (High & Medium), Sub-type (Primary & Secondary), ... Infrastructure & Transportation & Power Generation) - Trends ... GIS market with analysis and forecasting of the ... Data Tables with 52 Figures spread through 146 ...
(Date:10/27/2014)... MA (PRWEB) October 27, 2014 ... profit. SoundConnect , an industry leading unified ... its partners and agents to deliver cloud-based audio ... accelerate growth opportunities. , With SoundConnect’s Q4 ... every twenty-five video and/or web conferencing licenses sold, ...
Breaking Biology Technology:Health Canada approves first near-patient DNA test for personalized medicine 2Health Canada approves first near-patient DNA test for personalized medicine 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 2New report shows Indiana's gains in life sciences innovation capital outpace the nation 3New report shows Indiana's gains in life sciences innovation capital outpace the nation 4New report shows Indiana's gains in life sciences innovation capital outpace the nation 5Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 2Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 3Gas Insulated Switchgear Market worth $21,951.9 Million by 2019 - New Report by MarketsandMarkets 4SoundConnect Unveils Q4 Partner Incentives 2
Cached News: