HOME >> BIOLOGY >> NEWS
Hormone resistance of pituitary tumors and Cushing disease explained

Montral scientists led by Dr Jacques Drouin, researcher at the Institut de recherches cliniques de Montral (IRCM), and collaborators from around the world (Canada, France, the Netherlands and United States) unravel mechanism of hormone resistance in pituitary tumors of Cushing disease patients.

Cushing disease is caused by pituitary tumors that produce excessive amounts of hormone because the tumor cells have become resistant to negative feedback control by a class of steroid hormones, glucocorticoids. In Cushing disease, this excessive hormone production can lead to hypertension, obesity, diabetes and osteoporosis. Through detailed molecular investigation of the mechanism of this negative feedback, a Montral research group has identified two essential components (proteins) of this feedback mechanism. Extrapolating from these basic studies, they have shown that about half of the pituitary tumors from Cushing disease patients are deficient in expression of either of these proteins, thus providing a molecular explanation for the hormone resistance that is the hallmark, and likely first event, in the formation of these tumors. The novel insight provided by knowledge of the basic mechanism of hormone resistance will lead to the rational design of therapeutic approaches for the better management of Cushing disease patients. This insight will also help understand other forms of hormone resistant cancers.

Dr. Jacques Drouin is the Director of the Molecular Genetics Research Unit at IRCM. He holds the GlaxoSmithKline Chair in Molecular Genetics. The IRCM (www.ircm.qc.ca) is recognized as one of the country's top-performing research centres. It has a mandate to establish links between research and patients, promote the prevention of illness, and train a new generation of high-level scientists. The IRCM has 37 research units and a staff of more than 450. The IRCM is also affiliated to Universit de Montral.


'"/>

Contact: Lucette Thriault
lucette.theriault@ircm.qc.ca
514-987-5535
Institut de recherches cliniques de Montreal
23-Oct-2006


Page: 1

Related biology news :

1. Hormone that signals fullness also curbs fast food consumption and tendency to binge eat
2. Hormone therapy does not improve quality of life for women
3. Hormones role in insects could give insight for cancer treatment, malnutrition
4. Hormones may affect how brain listens, Emory study finds
5. Hormone might cause dangerous pregnancy complication
6. Hormones and growth: The control of body size and developmental growth rate in fruit flies
7. Hormone therapys effect on breast density is not the same for all women, Group Health study finds
8. Support for chromosomal theory of cancer found in cancers development of drug resistance
9. 454 sequencing identifies HIV drug resistance at early stage
10. Ultra deep sequencing identifies HIV drug resistance at early stage
11. Cytokine resistance contributes to pathology of type 2 diabetes

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/23/2020)... ... June 22, 2020 , ... The field of quantitation of ... assays (LBA) have dominated this area. However, the use of mass spectrometry in this ... now necessitates the question “How do you choose which approach to use (LBA or ...
(Date:6/19/2020)... ... June 16, 2020 , ... The director of stem cell biotechnology company ... cell medicine and pharmaceutical industries have easier access to stem cell counting, they will ... of this year, Independence Day weekend in the U.S., Asymmetrex is offering free tissue ...
(Date:6/13/2020)... ... 11, 2020 , ... Bode Technology (Bode), a ... genealogy team. Bode’s Forensic Genealogy Service (FGS) continues to deliver investigative ... methods. The team has added experienced genealogists, each having over a decade of ...
Breaking Biology News(10 mins):
(Date:6/19/2020)... ... June 18, 2020 , ... The Vitaspace ... is to join forces to radically prolong life and find a way (medicine or ... period. This project was supported by various scientists from all over the world, doctors, ...
(Date:6/11/2020)... ... 2020 , ... Reducing carbon emissions has been and will continue to be ... market dips, ways to reduce CO2 is something we can’t avoid. , To ... biofuels being produced today are created from recycled cooking oil or crops. Unfortunately, these ...
(Date:5/30/2020)... ... May 29, 2020 , ... The Conference Forum is ... solely dedicated to the unique role of the Chief Medical Officer in the ... responsibilities, problem-solving, best practices and career development of CMOs and Heads of R&D ...
(Date:5/21/2020)... ... May 21, 2020 , ... Threats ... cause long-term harm , Contrary to conventional wisdom that says the coronavirus pandemic ... many companies will emerge from the pandemic commercially weaker, dealing with delays in ...
Breaking Biology Technology:
Cached News: