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Hormone that signals fullness also curbs fast food consumption and tendency to binge eat

double-blind study

Eighty eight volunteers, comprised of obese men and obese post-menopausal women, 25-60 years old, took part in the 6-week study. (Pre-menopausal females were excluded because estrogen affects hunger and eating.) Participants were divided into treatment and placebo groups at a 2:1 ratio. Neither participants nor investigators knew which subjects were receiving placebo and which pramlintide.

Participants began with a four-day inpatient stay. All subjects received placebo during the first two days. The treatment period began on day three. The subjects received pramlintide or placebo via subcutaneous injection 15 minutes prior to each meal: breakfast, lunch and dinner. They continued their assigned regimen during a 5-week outpatient period (days 5-41) but reported for brief visits to the research unit on days 17 and 31. They returned for a final three days as inpatients, ending the experiment at day 44.

Participants maintained their typical exercise habits and made no lifestyle changes that could account for weight loss. During the inpatient stays, food intake was measured throughout the day under carefully controlled conditions. Participants were allowed to eat as much as they wanted but were told to eat until they were comfortably full.

On inpatient days 1, 3, and 43, offerings included such foods as bagels and cream cheese, muffins, cereal, fruit, sandwiches, casseroles, salads, tortilla chips, potato chips, cookies and soft drinks. They were also offered an evening snack that included peanut butter sandwiches and a cookie.

On inpatient days 2, 4, and 44, participants received a high-fat, high-sugar lunch that included deep-dish pizzas, ice cream and high fructose corn syrup-sweetened soft drinks. These three meals were the fast-food challenge.

The participants 24-hour food intake was measured on the first day of the experiment, when all were given a placebo, the first treatment day,
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Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
7-Jun-2007


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