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Hormone that signals fullness also curbs fast food consumption and tendency to binge eat

(day 3) and on day 43. The participants rated their feelings of hunger, fullness and nausea throughout these days using a hand-held electronic device. Participants also completed a 16-item questionnaire on days 1 and 42 that was designed to measure binge eating tendencies.

The researchers looked at weight, portion size, 24-hour caloric intake and consumption at a fast food challenge.

Weight: Participants who received pramlintide lost significantly more weight than those who received placebo. This finding fits with earlier research with rodents and some human studies. The pramlintide group lost an average of 4.5 pounds, about 2% of total body weight, while the placebo group remained about the same weight. The weight loss was in line with a 3.7% weight loss during an earlier 16-week study, the authors said.

Calories: The pramlintide group ate significantly fewer calories compared to the first two days of the experiment, before treatment started. On day 3, the first day of treatment, the pramlintide group decreased their food intake by 990 calories while the placebo group decreased caloric intake by a more modest 243 calories. On day 43, the pramlintide group was still ingesting significantly fewer calories (680 less) compared to what they consumed before treatment began. By comparison, the placebo group ate only 191 fewer calories on day 43.

Portion control: Within the inpatient setting, the overall reduction in 24-hour caloric intake with pramlintide was attributable to subjects eating smaller portions at each major meal. What is more, the researchers found that the pramlintide group felt just as full and satiated as the placebo group, even though the pramlintide group was eating considerably less. This suggests that pramlintide participants did not experience the increased feeling of hunger and food craving that often occurs when food intake is reduced with dieting, Weyer said

Fast food intake and binge eating: The
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Contact: Christine Guilfoy
cguilfoy@the-aps.org
301-634-7253
American Physiological Society
7-Jun-2007


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