HOME >> BIOLOGY >> NEWS
Hot on the TRAIL of controlling inflammation in bacterial meningitis

In a study appearing online on June 14 in advance of publication in the July print issue of the Journal of Clinical Investigation, researchers at Charit Universittsmedizin Berlin report that the molecule known as TRAIL can limit excessive immune responses in bacterial meningitis and as such may be of use to control inflammation of the spinal cord and brain, which causes brain cell death in this life-threatening disease.

Pneumococcal meningitis involves inflammation of the protective membranes covering the brain and spinal cord and is caused by infection with the bacterium Streptococcus pneumoniae. The observed swelling of the brain is largely the result of the excessive immune response to infection. The tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) has been previously reported to play a role in the regulation of the host immune response. In the current study, Joerg Weber and colleagues administered components of Streptococcus pneumoniae bacteria to the cerebrospinal fluid bathing the brain and spinal cord of mice lacking TRAIL. They found that these animals suffered from increased inflammation and brain cell death, however these effects were reversed by the administration of recombinant TRAIL (rTRAIL). Importantly, the application of rTRAIL to mice with intact TRAIL and meningitis also decreased inflammation and neuronal cell death. Finally, the authors observed that human patients with bacterial meningitis showed increased synthesis in the cerebrospinal fluid of TRAIL. The results of the study provide evidence that TRAIL acts to limit inflammation of the brain and spinal cord during bacterial meningitis, suggesting that it may be of use as an anti-inflammatory agent in invasive bacterial infections.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
14-Jun-2007


Page: 1

Related biology news :

1. Scientists follow familiar TRAIL to new cancer therapy
2. Is liver damage down the TRAIL for a promising cancer therapy?
3. Decreased breast cancer survival associated with high TRAIL-R2 expression
4. Revealed -- Mosquito genes that could be controlling the spread of killer viruses
5. Antibody-based therapies effective at controlling malaria
6. Information processing in the central nervous system: the signalling system controlling movement
7. Gene controlling circadian rhythms may be involved in onset of bipolar disorder
8. Edge density key to controlling gypsy moth spread
9. Electronic chip, interacting with the brain, modifies pathways for controlling movement
10. Climate change not the only factor controlling distribution of plant species
11. Important gene controlling tree growth and development found

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/12/2019)... Calif. (PRWEB) , ... March 12, 2019 , ... ... in strong multi-factor authentication and combined technology all-in-one smart cards, announced today the ... FIDO strong authentication: the Fingerprint Biometric and Dynamic CVV Payment cards. These advanced ...
(Date:3/9/2019)... ... March 07, 2019 , ... ... and cellular stress research tools today announced the publication of its recent ... treatment. The antibody, still at a pre-clinical stage of development, moves the company ...
(Date:3/1/2019)... ... March 01, 2019 , ... Geneious would like to announce it is ... to Vector NTI. , Geneious Prime already has a dedicated importer for Vector ... so that files will be organised in Geneious in the same way. The ...
Breaking Biology News(10 mins):
(Date:3/14/2019)... (PRWEB) , ... March 13, 2019 , ... Murrieta ... The Board will bring industry specific and broader business experience to bear as genomic ... to have access to the knowledge and expertise that our Advisory Board brings to ...
(Date:3/11/2019)... ... March 11, 2019 , ... In this live webinar, the featured ... clinical trial efficiency and experience. Participants will learn how to use the information they ... ensure that the simple or complex randomization scheme is properly designed and set up ...
(Date:3/5/2019)... , ... March 05, 2019 , ... ... cold chain engineering firm with regulatory filing authorities, logistics network experts, and experienced ... to initiate its participation in the Inc. Verified Profile program, Inc. editors independently ...
(Date:2/22/2019)... ... February 20, 2019 , ... Murrieta Genomics , the ... rapidly growing NGS (Next Generation Sequencing) field, have announced a partnership to bring ... "As an innovation center and idea incubator, we are always looking for new ...
Breaking Biology Technology:
Cached News: