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How bacteria break B cell tolerance

IMMUNOLOGY

How bacteria break B cell tolerance

There is a lot of indirect evidence that microbial infections can initiate and/or worsen autoimmune disease. Autoantibody production during infection results from activation of low-affinity autoreactive B cells. But how this could lead to autoimmune disease is not clear.

In a study appearing online on July 21 in advance of print publication of the August 1 issue of the Journal of Clinical Investigation, Thierry Martin and colleagues from INSERM show in vivo that an experimental infectious disease creates the necessary and sufficient conditions to activate self-reactive B cells with significant affinity. This could drive them to mature into harmful memory B cells and lead to autoimmune diseases in susceptible individuals.


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Contact: Stacie Bloom
press_releases@the-jci.org
212-342-4159
Journal of Clinical Investigation
21-Jul-2005


Page: 1

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