HOME >> BIOLOGY >> NEWS
How do the rules of immunity change during chronic infections?

(PHILADELPHIA) -- After a viral infection, a small percentage of the T cells generated to kill virus-infected cells remain on guard to establish long-term immunity. These so-called memory T cells, which derive from a family of immune cells known as CD8 T cells, engage in a self-renewal process that is essential to their persistence. This ongoing process ensures effective protection against any repeat infection by the same virus, even decades later.

But not all infections are equal. While most viral infections are cleared from the body within a few days or weeks, some infections, such as HIV or hepatitis C infections, become chronic. Some studies have suggested that the virus-specific CD8 T cells generated during a chronic infection may not develop the same characteristics as the CD8 T cells that persist after an acute infection.

Now, scientists at The Wistar Institute have found that the CD8 T cells generated to fight a chronic infection operate under an entirely different maintenance scheme than do the CD8 T cells that become memory T cells following an acute infection, becoming wholly dependent upon the presence of virus for their continuation. Details of the study will appear in the April 16 issue of The Journal of Experimental Medicine, published online April 9.

In addition, the CD8 T cells maintained during chronic infections establish a distinct pattern of cell division that creates a rapid turnover of cells, a characteristic that could be manipulated to design new therapeutic options for chronic infections, says E. John Wherry, Ph.D., senior author on the study and an assistant professor in the Immunology Program at Wistar.

"It appears the immune system responds to viral infections with two very different cell types," Wherry says. "In one case, when virus is completely cleared, you have a memory T cell capable of self-renewal. But during chronic infection, you have a totally different type of T cell that is not gover
'"/>

Contact: Franklin Hoke
hoke@wistar.org
215-898-3716
The Wistar Institute
9-Apr-2007


Page: 1 2 3

Related biology news :

1. Committee review of stem-cell fraud finds editors followed all rules
2. Define precautionary principle to avoid clashes over biotechnology under World Trade rules
3. Scientists uncover rules for gene amplification
4. Researchers create functioning artificial proteins using natures rules
5. Clear rules needed to govern deep sea bioprospecting: UNU
6. For young canaries learning their song, freedom in youth gives way to rules in adulthood
7. On the defense: Conserved features of plant innate immunity
8. The opossum genome sequence casts light on evolution, immunity and disease
9. Insight into evolution of adaptive immunity boosted by sea urchin genome sequencing
10. Killer B cells provide new link in the evolution of immunity
11. Fruit flies aboard space shuttle subjects of UCF, UC Davis study on immunity and space

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:7/22/2020)... ... July 21, 2020 , ... ... and innovation in technology and compliance, announces a new solution to manage regulated ... ensure every layer of their technology stack complies with FDA and global regulations. ...
(Date:7/10/2020)... FALLS CHURCH, Va. (PRWEB) , ... July 08, ... ... , The Latest on Cell and Gene Therapy Regulation, An FDAnews Webinar, Wednesday, ... product may need a comparability study, but what is the most effective way ...
(Date:7/2/2020)... REDWOOD CITY, Calif. (PRWEB) , ... July 01, ... ... stage biotech company, presented its phase 1a findings of Neihulizumab, a biologic for ... annual conference in June 2020. Led by hemato-oncologist Dr. Paul J Martin of ...
Breaking Biology News(10 mins):
(Date:8/15/2020)... (PRWEB) , ... August 13, 2020 , ... ... its annual Inc. 5000 list, the most prestigious ranking of the nation’s fastest-growing ... within the American economy’s most dynamic segment—its independent small businesses. Intuit, Zappos, Under ...
(Date:8/7/2020)... ... August 06, 2020 , ... VGXI, a highly ... closed on the purchase of greenfield for a new, expanded manufacturing facility. The ... 21 acres in the initial acquisition, with an option to purchase an additional ...
(Date:7/31/2020)... ... July 29, 2020 , ... G-CON Manufacturing, the leader ... tagline, “BUILDING FOR LIFE.” The adoption of this taglines comes at a time ... track capacity to provide patients with urgently needed vaccines and other lifesaving pharmaceutical ...
(Date:7/31/2020)... ... ... eSource has long been touted as the solution to high data management and monitoring ... did not take off as quickly as people initially expected, and where eSource is ... data electronically for clinical trials and then repurposing it for downstream analysis, at a ...
Breaking Biology Technology:
Cached News: